Search Results - "FIDEL, PAUL L."

Impaired neutrophil extracellular trap-forming capacity contributes to susceptibility to chronic vaginitis in a mouse model of vulvovaginal candidiasis by Yano, Junko, Fidel, Jr, Paul L

“…Vulvovaginal candidiasis (VVC), caused by is characterized by aberrant inflammation by polymorphonuclear neutrophils (PMNs) in the vaginal lumen. Data from the…”
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Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection? by Fidel, Jr, Paul L, Noverr, Mairi C

“…We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure…”
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Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework by Jabra-Rizk, Mary Ann, Kong, Eric F, Tsui, Christina, Nguyen, M Hong, Clancy, Cornelius J, Fidel, Jr, Paul L, Noverr, Mairi

“…Historically, the nature and extent of host damage by a microbe were considered highly dependent on virulence attributes of the microbe. However, it has become…”
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Fungal Morphogenetic Pathways Are Required for the Hallmark Inflammatory Response during Candida albicans Vaginitis by Peters, Brian M, Palmer, Glen E, Nash, Andrea K, Lilly, Elizabeth A, Fidel, Jr, Paul L, Noverr, Mairi C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Current patient perspectives of vulvovaginal candidiasis: incidence, symptoms, management and post-treatment outcomes by Yano, Junko, Sobel, Jack D, Nyirjesy, Paul, Sobel, Ryan, Williams, Valerie L, Yu, Qingzhao, Noverr, Mairi C, Fidel, Jr, Paul L

“…Vulvovaginal candidiasis (VVC) is a common infection affecting women worldwide. Reports of patterns/risk factors/trends for episodic/recurrent VVC (RVVC) are…”
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Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: "Neutrophil Anergy" by Yano, Junko, Peters, Brian M, Noverr, Mairi C, Fidel, Jr, Paul L

“…For over 3 decades, investigators have studied the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) through clinical studies and animal…”
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Candida vaginitis: when opportunism knocks, the host responds by Peters, Brian M, Yano, Junko, Noverr, Mairi C, Fidel, Jr, Paul L

“…  Current research has elucidated a major paradigm shift in the philosophy of Candida vaginitis pathogenesis, highlighting the role of the host innate immune…”
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A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase by MacAlpine, Jessie, Daniel-Ivad, Martin, Liu, Zhongle, Yano, Junko, Revie, Nicole M., Todd, Robert T., Stogios, Peter J., Sanchez, Hiram, O’Meara, Teresa R., Tompkins, Thomas A., Savchenko, Alexei, Selmecki, Anna, Veri, Amanda O., Andes, David R., Fidel, Paul L., Robbins, Nicole, Nodwell, Justin, Whitesell, Luke, Cowen, Leah E.

“…The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies…”
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The Neutral Vaginal pH in Mice That Is Typical of Most Mammalian Species Should Not Deter Research Using Experimental Murine Models of Candida Vaginitis by Fidel, Jr, Paul L

“…For over three decades, investigators have used estrogen-dependent rodent animal models to study pathogenesis of vulvovaginal candidiasis (VVC) or test…”
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Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis by Yano, Junko, Lilly, Elizabeth, Barousse, Melissa, Fidel, Paul L. Jr

“…Vulvovaginal candidiasis (VVC), caused by Candida species, is a significant problem in women of childbearing age. Similar to clinical observations, a robust…”
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Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis by Yano, Junko, Noverr, Mairi C, Fidel, Jr, Paul L

“…Despite acute inflammation by polymorphonuclear neutrophils (PMNs) during vulvovaginal candidiasis (VVC), clearance of fails to occur. The purpose of this…”
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Trained Innate Immunity Induced by Vaccination with Low-Virulence Candida Species Mediates Protection against Several Forms of Fungal Sepsis via Ly6G + Gr-1 + Leukocytes by Lilly, Elizabeth A, Bender, Breah E, Esher Righi, Shannon, Fidel, Jr, Paul L, Noverr, Mairi C

“…We recently discovered a novel form of trained innate immunity (TII) induced by low-virulence species (i.e., Candida dubliniensis) that protects against lethal…”
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Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections by Cruz, Melissa R., Cristy, Shane, Guha, Shantanu, De Cesare, Giuseppe Buda, Evdokimova, Elena, Sanchez, Hiram, Borek, Dominika, Miramón, Pedro, Yano, Junko, Fidel, Paul L., Savchenko, Alexei, Andes, David R., Stogios, Peter J., Lorenz, Michael C., Garsin, Danielle A.

“…Fungal pathogens are a continuing challenge due to few effective antifungals and a rise in resistance. In previous work, we described the inhibition of Candida…”
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Candida -induced granulocytic myeloid-derived suppressor cells are protective against polymicrobial sepsis by Esher Righi, Shannon, Harriett, Amanda J, Lilly, Elizabeth A, Fidel, Jr, Paul L, Noverr, Mairi C

“…Polymicrobial intra-abdominal infections are serious clinical infections that can lead to life-threatening sepsis, which is difficult to treat in part due to…”
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A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection by Paul, Saikat, Todd, Olivia A, Eichelberger, Kara R, Tkaczyk, Christine, Sellman, Bret R, Noverr, Mairi C, Cassat, James E, Fidel, Jr, Paul L, Peters, Brian M

“…Candida albicans and Staphylococcus aureus are two commonly associated pathogens that cause nosocomial infections with high morbidity and mortality. Our prior…”
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Transcriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome by Bruno, Vincent M, Shetty, Amol C, Yano, Junko, Fidel, Jr, Paul L, Noverr, Mairi C, Peters, Brian M

“…Treatment of vulvovaginal candidiasis (VVC), caused most frequently by Candida albicans, represents a significant unmet clinical need. C. albicans, as both a…”
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Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients by Gold, Jeffrey E, Baumgartl, William H, Okyay, Ramazan A, Licht, Warren E, Fidel, Jr, Paul L, Noverr, Mairi C, Tilley, Larry P, Hurley, David J, Rada, Balázs, Ashford, John W

“…The measles-mumps-rubella (MMR) vaccine has been theorized to provide protection against coronavirus disease 2019 (COVID-19). Our aim was to determine whether…”
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Bone Regeneration in Maxillary Sinus Augmentation Using Advanced Platelet-Rich Fibrin (A-PRF) and Plasma Rich in Growth Factors (PRGF): A Pilot Randomized Controlled Trial by Dragonas, Panagiotis, Prasad, Hari S, Yu, Qingzhao, Mayer, Elizabeth T, Fidel, Jr, Paul L

“…The purpose of this pilot randomized controlled trial was to analyze and compare the effects of advanced platelet-rich fibrin (A-PRF) and plasma rich in growth…”
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Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis by Fazly, Ahmed, Jain, Charu, Dehner, Amie C., Issi, Luca, Lilly, Elizabeth A., Ali, Akbar, Cao, Hong, Fidel, Paul L., Rao, Reeta P., Kaufman, Paul D.

“…Infection by pathogenic fungi, such as Candida albicans , begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By…”
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Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis by Yano, Junko, Yu, Alika, Fidel, Jr, Paul L, Noverr, Mairi C

“…Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise…”
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