Search Results - "FICHTINGER, A. M. J"

The formation and persistence of carboplatin-DNA adducts in rats by BLOMMAERT, F. A, MICHAEL, C, VAN DIJK-KNIJNENBURG, H. C. M, SCHORNAGEL, J. H, DEN ENGELSE, L, FICHTINGER-SCHEPMAN, A. M. J

“…The formation and persistence of platinum-DNA adducts were studied with immuno(cyto)chemical methods in male and female Sprague-Dawley rats treated with a…”
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Pharmacodynamics of cisplatin in human head and neck cancer: correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo by WELTERS, M. J. P, FICHTINGERCONEPHIAN, A. M. J, BAAN, R. A, JACOBS-BERGMANS, A. J, KEGEL, A, VAN DER VIJGH, W. J. F, BRAAKHUIS, B. J. M

“…Total platinum contents and cisplatin-DNA adduct levels were determined in vivo in xenografted tumour tissues in mice and in vitro in cultured tumour cells of…”
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The potential of platinum-DNA adduct determination in ex vivo treated tumor fragments for the prediction of sensitivity to cisplatin chemotherapy by Welters, M. J. P., Braakhuis, B. J. M., Jacobs-Bergmans, A. J., Kegel, A., Baan, R. A., van der Vijgh, W. J. F., Fichtinger-Schepman, A. M. J.

“…Background: Response to cisplatin-therapy is assumed to be related to the formation of platinum (Pt)-DNA adducts. Measurement of these adducts prior to therapy…”
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Resistance and cross-resistance of the IgM immunocytoma in the LOU/M Wsl rat for cisplatin, carboplatin, and iproplatin by STEERENBERG, P. A, VENDRIK, C. P. J, DE JONG, W. H, DE GROOT, G, FICHTINGER-SCHEPMAN, A. M. J, SCHEEFHALS, A. P. H, SCHORNAGEL, J. H

“…We investigated the antitumor activity of cis-diammine[1,1-cyclobutanedicarboxylato]platinum(II) (CBDCA, JM8) and…”
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Cisplatin–DNA adduct formation in rat spermatozoa and its effect on fetal development by Hooser, Stephen B., van Dijk-Knijnenburg, Wilhelmina C.M., Waalkens-Berendsen, Ine D.H., Smits-van Prooije, Annette E., Snoeij, Niek J., Baan, Robert A., Fichtinger-Schepman, Anne Marie J.

“…Exposure of males to some genotoxic chemicals causes DNA damage in spermatozoa resulting in embryotoxicity and developmental defects in their offspring. This…”
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cis-diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II) by FICHTINGER-SCHEPMAN, A. M. J, VAN OOSTEROM, A. T, LOHMAN, P. H. M, BERENDS, F

“…The same four platinum-containing products identified in nucleolytic digests of DNA treated with cisplatin (cisDDP) in vitro now have been shown to be present…”
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Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate by HILL, B. T, SHELLARD, S. A, HOSKING, L. K, DEMPKE, W. C. M, FICHTINGER, A. M. J, TAKESHI, S, TONE, T, SCANLON, K. J, WHELAN, R. D. H

“…In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90% inhibitory concentration of cisplatin (CDDP) (0.15…”
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Cisplatin- and carboplatin-DNA adducts: is PT-AG the cytotoxic lesion? by Fichtinger-Schepman, A M, van Dijk-Knijnenburg, H C, van der Velde-Visser, S D, Berends, F, Baan, R A

“…In order to determine the nature of the cytotoxic lesion(s) formed by the antitumour drugs cisplatin and carboplatin, a comparative study was made of…”
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Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines by WELTERS, M. J. P, FICHTINGER-SCHEPMAN, A. M. J, BAAN, R. A, FLENS, M. J, SCHEPER, R. J, BRAAKHUIS, B. J. M

“…Resistance to chemotherapy is a major problem in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Important factors involved are…”
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Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate by Treskes, M, Nijtmans, L G, Fichtinger-Schepman, A M, van der Vijgh, W J

“…The influence of the modulating agent WR2721, its active thiol-metabolite WR1065 and the symmetrical disulphide WR33278 on the in vitro formation and stability…”
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Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients by Korst, A E, van der Sterre, M L, Gall, H E, Fichtinger-Schepman, A M, Vermorken, J B, van der Vijgh, W J

“…The pharmacokinetics of cisplatin was investigated in 13 patients receiving 18 courses of cisplatin alone or in combination with amifostine to investigate the…”
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Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis-diamminedichloroplatinum(II) in vitro by HOSPERS, G. A. P, MULDER, N. H, DE JONG, B, DE LEY, L, UGES, D. R. A, FICHTINGER-SCHEPMAN, A. M. J, SCHEPER, R. J, DE VRIES, E. G. E

“…A 6.4-fold cis-diamminedichloroplatinum(II) (CDDP) resistant human small cell lung carcinoma cell line (GLC4-CDDP) was developed to study acquired CDDP…”
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Kinetics of the formation and removal of cisplatin-DNA adducts in blood cells and tumor tissue of cancer patients receiving chemotherapy : comparison with in vitro adduct formation by FICHTINGER-SCHEPMAN, A. M. J, VAN DER VELDE-VISSER, S. D, VAN DIJK-KNIJNENBURG, H. C. M, VAN OOSTEROM, A. T, BAAN, R. A, BERENDS, F

“…During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main…”
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Relationship between the parameters cellular differentiation, doubling time and platinum accumulation and cisplatin sensitivity in a panel of head and neck cancer cell lines by Welters, Marij J.P., Fichtinger‐Schepman, Anne Marie J., Baan, Robert A., Hermsen, Mario A.J.A., van der Vijgh, Wim J.F., Cloos, Jacqueline, Braakhuis, Boudewijn J.M.

“…Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin show a large inter‐individual variation in tumor response. Little is known…”
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Pharmacokinetics of cisplatin with and without amifostine in tumour-bearing nude mice by Korst, A.E.C., Boven, E., van der Sterre, M.L.T., Fichtinger-Schepman, A.M.J., van der Vijgh, W.J.F.

“…Amifostine (Ethyol, WR-2721) is in use in the clinic as a protector against platinum-induced toxicities. We have previously reported that amifostine induced a…”
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Differential repair of platinum-DNA adducts in human bladder and testicular tumor continuous cell lines by BEDFORD, P, FICHTINGER-SCHEPMAN, A. M. J, SHELLARD, S. A, WALKER, M. C, MASTERS, J. R. W, HILL, B. T

“…The formation and removal of four platinum-DNA adducts were immunochemically quantitated in cultured cells derived from a human bladder carcinoma cell line…”
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Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors by KORST, A. E. C, VAN DER STERRE, M. L. T, EELTINK, C. M, FICHTINGER-SCHEPMAN, A. M. J, VERMORKEN, J. B, VAN DER VIJGH, W. J. F

“…We showed previously that amifostine (WR 2721; Ethyol), a protector against carboplatin-induced toxicities, changed the pharmacokinetics of carboplatin in…”
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Enhanced DNA repair and tolerance of DNA damage associated with resistance to cis-diammine-dichloroplatinum (II) after in vitro exposure of a human teratoma cell line to fractionated X-irradiation by Hill, B T, Shellard, S A, Hosking, L K, Fichtinger-Schepman, A M, Bedford, P

“…In vitro exposure of a human testicular teratoma continuous cell line to fractionated X-irradiation resulted in the expression of resistance to cisplatin. In…”
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Effect of cisplatin exposure on platinum accumulation and growth inhibition in human neoplastic and normal squamous epithelial cells of the mucosa of the upper-aerodigestive tract by Braakhuis, Boudewijn J.M, Welters, Marij J.P, Cloos, Jacqueline, Pankras, Jeannette E, Smeets, Serge J, Fichtinger-Schepman, Anne-Marie J

“…The aim of the present study was to investigate how normal head and neck epithelial cells (NHNEC) respond to cisplatin compared to their neoplastic…”
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Improved 32P-postlabelling assay for the quantification of the major platinum-DNA adducts by WELTERS, M. J. P, MALIEPAARD, M, JACOBS-BERGMANS, A. J, BAAN, R. A, SCHELLENS, J. H. M, MA, J, VAN DER VIJGH, W. J. F, BRAAKHUIS, B. J. M, FICHTINGER-SCHEPMAN, A. M. J

“…For the improvement of chemotherapy with platinum (Pt)-containing drugs a sensitive assay to detect the induced Pt-DNA adducts is needed. Therefore, the…”
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