Search Results - "FERWERDA, Bart"

A Genetic Map of the Modern Urban Society of Amsterdam by Ferwerda, Bart, Abdellaoui, Abdel, Nieuwdorp, Max, Zwinderman, Koos

“…Genetic differences between individuals underlie susceptibility to many diseases. Genome-wide association studies (GWAS) have discovered many susceptibility…”
Get full text

Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis by Fritz, Daan, Ferwerda, Bart, Brouwer, Matthijs C., van de Beek, Diederik

“…Objective We studied genetic risk factors associated with sarcoidosis within a family with a high prevalence of this disease. Methods We studied 41 members of…”
Get full text

Evolutionary History and Adaptation from High-Coverage Whole-Genome Sequences of Diverse African Hunter-Gatherers by Lachance, Joseph, Vernot, Benjamin, Elbers, Clara C., Ferwerda, Bart, Froment, Alain, Bodo, Jean-Marie, Lema, Godfrey, Fu, Wenqing, Nyambo, Thomas B., Rebbeck, Timothy R., Zhang, Kun, Akey, Joshua M., Tishkoff, Sarah A.

“…To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five…”
Get full text

Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis by Savva, Athina, Brouwer, Matthijs C., Roger, Thierry, Serón, Mercedes Valls, Le Roy, Didier, Ferwerda, Bart, van der Ende, Arie, Bochud, Pierre-Yves, van de Beek, Diederik, Calandra, Thierry

“…Pneumococcal meningitis is the most frequent and critical type of bacterial meningitis. Because cytokines play an important role in the pathogenesis of…”
Get full text

Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies by Jarvis, Joseph P, Scheinfeldt, Laura B, Soi, Sameer, Lambert, Charla, Omberg, Larsson, Ferwerda, Bart, Froment, Alain, Bodo, Jean-Marie, Beggs, William, Hoffman, Gabriel, Mezey, Jason, Tishkoff, Sarah A

“…African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical…”
Get full text

Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection by Zhernakova, Alexandra, Elbers, Clara C., Ferwerda, Bart, Romanos, Jihane, Trynka, Gosia, Dubois, Patrick C., de Kovel, Carolien G.F., Franke, Lude, Oosting, Marije, Barisani, Donatella, Bardella, Maria Teresa, Joosten, Leo A.B., Saavalainen, Paivi, van Heel, David A., Catassi, Carlo, Netea, Mihai G., Wijmenga, Cisca

“…Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a…”
Get full text

FHL2 Genetic Polymorphisms and Pro-Diabetogenic Lipid Profile in the Multiethnic HELIUS Cohort by Habibe, Jayron J, Boulund, Ulrika, Clemente-Olivo, Maria P, de Vries, Carlie J M, Eringa, Etto C, Nieuwdorp, Max, Ferwerda, Bart, Zwinderman, Koos, van den Born, Bert-Jan H, Galenkamp, Henrike, van Raalte, Daniel H

“…Type 2 diabetes mellitus (T2D) is a prevalent disease often accompanied by the occurrence of dyslipidemia. Four and a half LIM domains 2 (FHL2) is a…”
Get full text

Pneumococcal genetic variability in age-dependent bacterial carriage by Kremer, Philip H C, Ferwerda, Bart, Bootsma, Hester J, Rots, Nienke Y, Wijmenga-Monsuur, Alienke J, Sanders, Elisabeth A M, Trzciński, Krzysztof, Wyllie, Anne L, Turner, Paul, van der Ende, Arie, Brouwer, Matthijs C, Bentley, Stephen D, van de Beek, Diederik, Lees, John A

“…The characteristics of pneumococcal carriage vary between infants and adults. Host immune factors have been shown to contribute to these age-specific…”
Get full text

Residual Variation Intolerance Score Detects Loci Under Selection in Neuroinvasive Listeria monocytogenes by Ferwerda, Bart, Maury, Mylène M, Brouwer, Mathijs C, Hafner, Lukas, van der Ende, Arie, Bentley, Stephen, Lecuit, Marc, van de Beek, Diederik

“…is a Gram-positive bacterium that can be found in a broad range of environments, including soil, food, animals, and humans. can cause a foodborne disease…”
Get full text

Sequencing of the variable region of rpsB to discriminate between Streptococcus pneumoniae and other streptococcal species by Wyllie, Anne L., Pannekoek, Yvonne, Bovenkerk, Sandra, van Engelsdorp Gastelaars, Jody, Ferwerda, Bart, van de Beek, Diederik, Sanders, Elisabeth A. M., Trzciński, Krzysztof, van der Ende, Arie

“…The vast majority of streptococci colonizing the human upper respiratory tract are commensals, only sporadically implicated in disease. Of these, the most…”
Get full text

Genetic Variation in Neisseria meningitidis Does Not Influence Disease Severity in Meningococcal Meningitis by Kremer, Philip H C, Lees, John A, Ferwerda, Bart, van de Ende, Arie, Brouwer, Matthijs C, Bentley, Stephen D, van de Beek, Diederik

“…causes sepsis and meningitis in humans. It has been suggested that pathogen genetic variation determines variance in disease severity. Here we report results…”
Get full text

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts by Kumpf, Oliver, Giamarellos-Bourboulis, Evangelos J, Koch, Alexander, Hamann, Lutz, Mouktaroudi, Maria, Oh, Djin-Ye, Latz, Eicke, Lorenz, Eva, Schwartz, David A, Ferwerda, Bart, Routsi, Christina, Skalioti, Chryssanthi, Kullberg, Bart-Jan, van der Meer, Jos W M, Schlag, Peter M, Netea, Mihai G, Zacharowski, Kai, Schumann, Ralf R

“…It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide…”
Get full text

Erratum to: Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis by Kasanmoentalib, E Soemirien, Seron, Mercedes Valls, Ferwerda, Bart, Tanck, Michael W, Zwinderman, Aeilko H, Baas, Frank, van der Ende, Arie, Schwaeble, William J, Brouwer, Matthijs C, van de Beek, Diederik

“…Upon publication of the original article [1], it was noticed that Prof William J Schwaeble was omitted from the author list. He has now been added in this…”
Get full text

Variation of 46 Innate Immune Genes Evaluated for their Contribution in Pneumococcal Meningitis Susceptibility and Outcome by Ferwerda, Bart, Valls Serón, Mercedes, Jongejan, Aldo, Zwinderman, Aeilko H., Geldhoff, Madelijn, van der Ende, Arie, Baas, Frank, Brouwer, Matthijs C., van de Beek, Diederik

“…Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Early recognition of the pathogen and subsequent innate immune response…”
Get full text

Functional Consequences of Toll-like Receptor 4 Polymorphisms by Ferwerda, Bart, McCall, Matthew B. B., Verheijen, Karlijn, Kullberg, Bart-Jan, van der Ven, André J. A. M., Van der Meer, Jos W. M., Netea, Mihai G.

Get full text

The loss of functional caspase-12 in Europe is a pre-neolithic event by Hervella, Montserrat, Plantinga, Theo S, Alonso, Santos, Ferwerda, Bart, Izagirre, Neskuts, Fontecha, Lara, Fregel, Rosa, van der Meer, Jos W M, de-la-Rúa, Concepcion, Netea, Mihai G

“…Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the "C" allele at CASP12 rs497116 has been associated with an increased risk of sepsis…”
Get full text

Caspase-12 and the inflammatory response to Yersinia pestis by Ferwerda, Bart, McCall, Matthew B B, de Vries, Maaike C, Hopman, Joost, Maiga, Boubacar, Dolo, Amagana, Doumbo, Ogobara, Daou, Modibo, de Jong, Dirk, Joosten, Leo A B, Tissingh, Rudi A, Reubsaet, Frans A G, Sauerwein, Robert, van der Meer, Jos W M, van der Ven, André J A M, Netea, Mihai G

“…Caspase-12 functions as an antiinflammatory enzyme inhibiting caspase-1 and the NOD2/RIP2 pathways. Due to increased susceptibility to sepsis in individuals…”
Get full text

2213 APOL1 high-risk genotype in in a Dutch multi-ethnic population by Manson, Nienke, van Schijndel, Emma, Ferwerda, Bart, Galenkamp, Henrike, Huisan, Brechje, Vogt, Liffert, Zwinderman, Koos, Bemelman, Frederike

“…Abstract Background and Aims The presence of 2 APOL1 high-risk alleles (high-risk APOL1 genotype) is associated with an increased risk of ESKD. In the USA, the…”
Get full text

GENETIC VARIANCE IN HEPARAN SULFATION IS ASSOCIATED WITH SALT-SENSITIVITY: A GENE-ENVIRONMENT ANALYSIS by Oppelaar, Jetta, Ferwerda, Bart, Romman, Mohamed, Sahebdin, Ghazalah, Zwinderman, Aeilko, Galenkamp, Henrike, Boekholdt, Matthijs, Van Den Born, Bert -Jan, Engberink, Rik Olde, Vogt, Liffert

“…Objective: The high heritability of salt sensitivity suggests an essential role for genetic variants in the relationship between sodium intake and blood…”
Get full text

Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity by Oppelaar, Jetta J, Ferwerda, Bart, Romman, Mohamed A, Sahebdin, Ghazalah N, Zwinderman, Aeilko H, Galenkamp, Henrike, Boekholdt, S Matthijs, van den Born, Bert-Jan H, Olde Engberink, Rik H G, Vogt, Liffert

“…High heritability of salt sensitivity suggests an essential role for genetics in the relationship between sodium intake and blood pressure (BP). The role of…”
Get full text