Search Results - "FERRAT, LAURIC A."

Classifying dynamic transitions in high dimensional neural mass models: A random forest approach by Ferrat, Lauric A, Goodfellow, Marc, Terry, John R

“…Neural mass models (NMMs) are increasingly used to uncover the large-scale mechanisms of brain rhythms in health and disease. The dynamics of these models is…”
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Logistic regression has similar performance to optimised machine learning algorithms in a clinical setting: application to the discrimination between type 1 and type 2 diabetes in young adults by Lynam, Anita L, Dennis, John M, Owen, Katharine R, Oram, Richard A, Jones, Angus G, Shields, Beverley M, Ferrat, Lauric A

“…There is much interest in the use of prognostic and diagnostic prediction models in all areas of clinical medicine. The use of machine learning to improve…”
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Identification of type 1 diabetes risk phenotypes using an outcome-guided clustering analysis by You, Lu, Ferrat, Lauric A., Oram, Richard A., Parikh, Hemang M., Steck, Andrea K., Krischer, Jeffrey, Redondo, Maria J.

“…Aims/hypothesis Although statistical models for predicting type 1 diabetes risk have been developed, approaches that reveal the heterogeneity of the at-risk…”
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37-OR: Childhood Screening and Interception Strategies: An Economic Cohort Simulation Model by TRUSHEIM, MARK, KOSTENSE, STEFAN, FERRAT, LAURIC A., MCQUEEN, R. BRETT, NEUSNER, ROBERT D., ORAM, RICHARD A., REWERS, MARIAN, DUNNE, JESSICA L.

“…T1D screening and monitoring studies suggest opportunities for scaling up to public health population-based programs. Genetic Risk Scores (GRS) for T1D are…”
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216-LB: Genetic Influences on Beta-Cell Function before Type 1 Diabetes Diagnosis by TRIOLO, TAYLOR M., PARIKH, HEMANG M., TOSUR, MUSTAFA, FERRAT, LAURIC A., YOU, LU, GOTTLIEB, PETER, ORAM, RICHARD A., ONENGUT-GUMUSCU, SUNA, KRISCHER, JEFFREY, RICH, STEPHEN S., STECK, ANDREA, REDONDO, MARIA J.

“…Autoimmune loss of beta-cell function (measured by C-peptide) is the hallmark of type 1 diabetes (T1D) targeted by interventions that aim to prevent T1D or its…”
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188-LB: Deep Learning–Based Population Screening of Type 1 Diabetes and Celiac Disease Genetic Risk from Blood Spots at Birth by SHARP, SETH A., LOCKE, JONATHAN M., XU, YU, FRASER, DIANE P., FERRAT, LAURIC A., WEEDON, MICHAEL N., INOUYE, MICHAEL, ORAM, RICHARD A., HAGOPIAN, WILLIAM

“…Introduction: Screening for type 1 diabetes (T1D) genetic risk in early life can prevent life threatening complications such as diabetic ketoacidosis and allow…”
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243-OR: Integrating Genetic Risk Score and Islet Autoantibody Characteristics in the Predictive Model for Type 1 Diabetes in the TrialNet Study by FERRAT, LAURIC A., STECK, ANDREA, PARIKH, HEMANG M., YOU, LU, ONENGUT-GUMUSCU, SUNA, GOTTLIEB, PETER, RICH, STEPHEN S., KRISCHER, JEFFREY, ORAM, RICHARD A., REDONDO, MARIA J.

“…Background: Type 1 diabetes (T1D) genetic risk score (GRS) and islet autoantibody (AAb) specificity and titers influence T1D risk; however, these factors…”
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210-OR: A Combined Method Improves Risk Prediction for Childhood Type 1 Diabetes in the TEDDY Study by FERRAT, LAURIC A., VEHIK, KENDRA, SHARP, SETH A., LERNMARK, ÅKE, ZIEGLER, ANETTE, REWERS, MARIAN, SHE, JIN-XIONG, TOPPARI, JORMA, AKOLKAR, BEENA, KRISCHER, JEFFREY, WEEDON, MICHAEL N., RICH, STEPHEN S., ORAM, RICHARD A., HAGOPIAN, WILLIAM

“…Background: There is an unmet need for accurate cost-effective estimation of future T1D risk. Methods: We derived a combined T1D prediction model using 7883…”
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82-OR: A T1D Genetic Risk Score Combined with Clinical Features and Autoantibodies Enables Accurate Diabetes Classification in a Racial/Ethnically Diverse Population: The Search for Diabetes in Youth Study by ORAM, RICHARD A., SHARP, SETH A., PIHOKER, CATHERINE, FERRAT, LAURIC A., IMPERATORE, GIUSEPPINA, SAYDAH, SHARON, WILLIAMS, ADRIENNE H., WAGENKNECHT, LYNNE E., LAWRENCE, JEAN M., WEEDON, MICHAEL N., DAGOSTINO, RALPH, HAGOPIAN, WILLIAM, DIVERS, JASMIN, DABELEA, DANA

“…Accurate classification of diabetes type guides correct treatment. We recently showed a type 1 diabetes (T1D) genetic risk score (GRS-1), combined with…”
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1443-P: Natural History of Type 1 Diabetes (T1D)-Contrasting Adult vs. Pediatric At-Risk Populations by Templeman, Erin, Ferrat, Lauric A, Thomas, Nicholas, Speake, Cate, Wherrett, Diane K, Sherr, Jennifer L, Redondo, Maria J, Evans-Molina, Carmella, Sosenko, Jay, Sims, Emily K, Oram, Richard A

“…Introduction: Adults represent over half of incident T1D cases but most studies on risk prediction focus on children. Methods: We studied 135,970 children (<18…”
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68-OR: Influence of the Type 1 Diabetes Genetic Risk Score on Response to Immunotherapies for Type 1 Diabetes Prevention by Redondo, Maria J, Bundy, Brian N, Parikh, Hemang M, You, Lu, Triolo, Taylor M, Ferrat, Lauric A, Templeman, Erin, Tosur, Mustafa, Steck, Andrea, Gottlieb, Peter, Onengut-Gumuscu, Suna, Rich, Stephen S, Oram, Richard A, Herold, Kevan C, Krischer, Jeffrey

“…Introduction & Objective: Teplizumab has shown efficacy at delaying the onset of type 1 diabetes (T1D) but markers of response to treatment are needed to…”
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154-OR: Genetic Predictors of Response to Oral Insulin for Type 1 Diabetes Prevention by You, Lu, Parikh, Hemang M, Triolo, Taylor M, Ferrat, Lauric A, Templeman, Erin, Oram, Richard A, Gottlieb, Peter, Rich, Stephen S, Onengut-Gumuscu, Suna, Steck, Andrea, Krischer, Jeffrey, Redondo, Maria J

“…Introduction: TrialNet TN07, a randomized controlled trial, assessed oral insulin for preventing type 1 diabetes (T1D) in autoantibody-positive relatives of…”
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Genetic Associations with C-peptide Levels before Type 1 Diabetes Diagnosis in At-Risk Relatives by Triolo, Taylor M, Parikh, Hemang M, Tosur, Mustafa, Ferrat, Lauric, You, Lu, Gottlieb, Peter A, Oram, Richard A, Onengut-Gumuscu, Suna, Krischer, Jeffrey P, Rich, Stephen S, Steck, Andrea K, Redondo, Maria J

“…We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms (SNPs) are associated with C-peptide…”
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