Search Results - "FERRARO, Thomas N"

Postmortem toxicology findings from the Camden Opioid Research Initiative by Kusic, Dara M, Heil, Jessica, Zajic, Stefan, Brangan, Andrew, Dairo, Oluseun, Heil, Stacey, Feigin, Gerald, Kacinko, Sherri, Buono, Russell J, Ferraro, Thomas N, Rafeq, Rachel, Haroz, Rachel, Baston, Kaitlan, Bodofsky, Elliot, Sabia, Michael, Salzman, Matthew, Resch, Alissa, Madzo, Jozef, Scheinfeldt, Laura B, Issa, Jean-Pierre J, Jelinek, Jaroslav

“…The United States continues to be impacted by decades of an opioid misuse epidemic, worsened by the COVID-19 pandemic and by the growing prevalence of highly…”
Get full text

Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study by McGarry, Andrew, Gaughan, John, Hackmyer, Cory, Lovett, Jacqueline, Khadeer, Mohammed, Shaikh, Hamza, Pradhan, Basant, Ferraro, Thomas N., Wainer, Irving W., Moaddel, Ruin

“…Huntington’s Disease (HD) is a progressive, fatal neurodegenerative condition. While generally considered for its devastating neurological phenotype,…”
Get full text

An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington’s disease by McGarry, Andrew, Hunter, Krystal, Gaughan, John, Auinger, Peggy, Ferraro, Thomas N., Pradhan, Basant, Ferrucci, Luigi, Egan, Josephine M., Moaddel, Ruin

“…Huntington’s disease (HD) is increasingly recognized for diverse pathology outside of the nervous system. To describe the biology of HD in relation to…”
Get full text

Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling by Lohoff, Falk W., Carr, Gregory V., Brookshire, Bethany, Ferraro, Thomas N., Lucki, Irwin

“…•VMAT1 has recently been identified as target for neuropsychiatric disorders.•This study investigated null-mutant VMAT1 animals for effects on monoamine…”
Get full text

Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake by Reiner, Benjamin C., Zhang, Yafang, Stein, Lauren M., Perea, Emilie Dávila, Arauco-Shapiro, Gabriella, Ben Nathan, Jennifer, Ragnini, Kael, Hayes, Matthew R., Ferraro, Thomas N., Berrettini, Wade H., Schmidt, Heath D., Crist, Richard C.

“…Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell type-specific…”
Get full text

Author Correction: Cross-sectional analysis of plasma and CSF metabolomic markers in Huntington’s disease for participants of varying functional disability: a pilot study by McGarry, Andrew, Gaughan, John, Hackmyer, Cory, Lovett, Jacqueline, Khadeer, Mohammed, Shaikh, Hamza, Pradhan, Basant, Ferraro, Thomas N., Wainer, Irving W., Moaddel, Ruin

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

BMAL1 controls the diurnal rhythm and set point for electrical seizure threshold in mice by Gerstner, Jason R, Smith, George G, Lenz, Olivia, Perron, Isaac J, Buono, Russell J, Ferraro, Thomas N

“…The epilepsies are a heterogeneous group of neurological diseases defined by the occurrence of unprovoked seizures which, in many cases, are correlated with…”
Get full text

Analysis of single-cell transcriptome data from a mouse model implicates protein synthesis dysfunction in schizophrenia by Weller, Andrew E., Ferraro, Thomas N., Doyle, Glenn A., Reiner, Benjamin C., Berrettini, Wade H., Crist, Richard C.

“…Background Schizophrenia is a mental disorder that causes considerable morbidity, whose risk largely results from genetic factors. Setd1a is a gene implicated…”
Get full text

The Molecular Genetic Interaction Between Circadian Rhythms and Susceptibility to Seizures and Epilepsy by Re, Christopher J, Batterman, Alexander I, Gerstner, Jason R, Buono, Russell J, Ferraro, Thomas N

“…Seizure patterns observed in patients with epilepsy suggest that circadian rhythms and sleep/wake mechanisms play some role in the disease. This review…”
Get full text

MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens by Petko, Jessica, Justice-Bitner, Stephanie, Jin, Jay, Wong, Victoria, Kittanakom, Saranya, Ferraro, Thomas N, Stagljar, Igor, Levenson, Robert

“…The mu-opioid receptor (MOR) is the G-protein coupled receptor primarily responsible for mediating the analgesic and rewarding properties of opioid agonist…”
Get full text

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure‐susceptible DBA/2 mice by Inyushin, Mikhail, Kucheryavykh, Lilia Y., Kucheryavykh, Yuriy V., Nichols, Colin G., Buono, Russell J., Ferraro, Thomas N., Skatchkov, Serguei N., Eaton, Misty J.

“…Summary Purpose:  KCNJ10 encodes subunits of inward rectifying potassium (Kir) channel Kir4.1 found predominantly in glial cells within the brain. Genetic…”
Get full text

Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative by Kusic, Dara, Heil, Jessica, Zajic, Stefan, Brangan, Andrew, Dairo, Oluseun, Smith, Gretchen, Morales-Scheihing, Diego, Buono, Russell J, Ferraro, Thomas N, Haroz, Rachel, Salzman, Matthew, Baston, Kaitlan, Bodofsky, Elliot, Sabia, Michael, Resch, Alissa, Scheinfeldt, Laura B

“…Pharmacogenetics (PGx) has the potential to improve opioid medication management. Here, we present patient perception data, pharmacogenetic data and medication…”
Get full text

Genetics and prescription opioid use (GaPO): study design for consenting a cohort from an existing biobank to identify clinical and genetic factors influencing prescription opioid use and abuse by Troiani, Vanessa, Crist, Richard C, Doyle, Glenn A, Ferraro, Thomas N, Beiler, Donielle, Ranck, Stephanie, McBryan, Kortney, Jarvis, Margaret A, Barbour, Jordan S, Han, John J, Ness, Ryan J, Berrettini, Wade H, Robishaw, Janet D

“…Prescription opioids (POs) are commonly used to treat moderate to severe chronic pain in the health system setting. Although they improve quality of life for…”
Get full text

The Genomics of Opioid Addiction Longitudinal Study (GOALS): study design for a prospective evaluation of genetic and non-genetic factors for development of and recovery from opioid use disorder by Heil, Jessica, Zajic, Stefan, Albertson, Emily, Brangan, Andrew, Jones, Iris, Roberts, Wendy, Sabia, Michael, Bodofsky, Elliot, Resch, Alissa, Rafeq, Rachel, Haroz, Rachel, Buono, Russell, Ferraro, Thomas N, Scheinfeldt, Laura, Salzman, Matthew, Baston, Kaitlan

“…The opioid use disorder and overdose crisis in the United States affects public health as well as social and economic welfare. While several genetic and…”
Get full text

Consensus clustering of single-cell RNA-seq data by enhancing network affinity by Cui, Yaxuan, Zhang, Shaoqiang, Liang, Ying, Wang, Xiangyun, Ferraro, Thomas N, Chen, Yong

“…Elucidation of cell subpopulations at high resolution is a key and challenging goal of single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) data analysis…”
Get full text

Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence by Lohoff, Falk W, Weller, Andrew E, Bloch, Paul J, Nall, Aleksandra H, Ferraro, Thomas N, Kampman, Kyle M, Pettinati, Helen M, Oslin, David W, Dackis, Charles A, O'Brien, Charles P, Berrettini, Wade H

“…Dopaminergic brain systems have been documented to have a major role in drug reward, thus making genes involved in these circuits plausible candidates for…”
Get full text

The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy by Löscher, Wolfgang, Ferland, Russell J., Ferraro, Thomas N.

“…It is becoming increasingly clear that the genetic background of mice and rats, even in inbred strains, can have a profound influence on measures of seizure…”
Get full text

In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression by Doyle, Glenn A, Wang, Min-Jung, Chou, Andrew D, Oleynick, John U, Arnold, Steven E, Buono, Russell J, Ferraro, Thomas N, Berrettini, Wade H

“…Genome-wide association studies implicate variations in CHRNA5 and CHRNA3 as being associated with nicotine addiction (NA). Multiple common haplotypes ("risk",…”
Get full text

Epidemiological study of Trichosporon asahii infections over the past 23 years by Li, Haitao, Guo, Meihong, Wang, Congmin, Li, Yibo, Fernandez, Anne Marie, Ferraro, Thomas N., Yang, Rongya, Chen, Yong

“…Trichosporon is a yeast-like basidiomycete, a conditional pathogenic fungus that is rare in the clinic but often causes fatal infections in immunocompromised…”
Get full text

Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits by Lohoff, Falk W., Lautenschlager, Marion, Mohr, Johannes, Ferraro, Thomas N., Sander, Thomas, Gallinat, Jürgen

“…Vesicular monoamine transporters are involved in the presynaptic packaging of norepinephrine, dopamine and serotonin into storage vesicles. The vesicles…”
Get full text