Search Results - "FERRARIS, V"

Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic by Ferraris, Dana V

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The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type by Yuneva, Mariia O., Fan, Teresa W.M., Allen, Thaddeus D., Higashi, Richard M., Ferraris, Dana V., Tsukamoto, Takashi, Matés, José M., Alonso, Francisco J., Wang, Chunmei, Seo, Youngho, Chen, Xin, Bishop, J. Michael

“…The altered metabolism of tumors has been considered a target for anticancer therapy. However, the relationship between distinct tumor-initiating lesions and…”
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Recent advances in the discovery of D-amino acid oxidase inhibitors and their therapeutic utility in schizophrenia by Ferraris, Dana V, Tsukamoto, Takashi

“…D-amino acid oxidase (DAAO) catalyzes the oxidative metabolism of D-amino acids including D-serine, a full agonist at the allosteric glycine binding site of…”
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Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) by Robinson, Mary M, McBryant, Steven J, Tsukamoto, Takashi, Rojas, Camilo, Ferraris, Dana V, Hamilton, Sean K, Hansen, Jeffrey C, Curthoys, Norman P

“…The release of GA (mitochondrial glutaminase) from neurons following acute ischaemia or during chronic neurodegenerative diseases may contribute to the…”
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More or less? The Goldilocks Principle as it applies to red cell transfusions by Shander, A, Ferraris, V.A.

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Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitors by Ferraris, D V, Shukla, K, Tsukamoto, T

“…Glutamate carboxypeptidase II (GCPII, EC 3.4.17.21) is a zinc metallopeptidase that hydrolyzes N-acetylaspartylglutamate (NAAG) into N-acetylaspartate (NAA)…”
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Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020) by Velagapudi, Uday Kiran, Patel, Bhargav A, Shao, Xuwei, Pathak, Sanjai Kumar, Ferraris, Dana V, Talele, Tanaji T

“…Discovery of small molecules that impede the activity of single-strand DNA repair enzyme, PARP1, has led to four marketed drugs for the treatment of…”
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Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors by Thomas, Ajit G., Rojas, Camilo, Tanega, Cordelle, Shen, Min, Simeonov, Anton, Boxer, Matthew B., Auld, Douglas S., Ferraris, Dana V., Tsukamoto, Takashi, Slusher, Barbara S.

“…•Ebselen, chelerythrine and apomorphine were identified as glutaminase inhibitors.•These had greater affinities and efficiency of inhibition than known…”
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Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome by Ferraris, J. R., Ferraris, V., Acquier, A. B., Sorroche, P. B., Saez, M. S., Ginaca, A., Mendez, C. F.

“…Summary Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of…”
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D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II by Gori, Sadakatali S, Thomas, Ajit G, Pal, Arindom, Wiseman, Robyn, Ferraris, Dana V, Gao, Run-Duo, Wu, Ying, Alt, Jesse, Tsukamoto, Takashi, Slusher, Barbara S, Rais, Rana

“…Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of…”
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Evaluation of Tamoxifen and Anastrozole in the Prevention of Gynecomastia and Breast Pain Induced by Bicalutamide Monotherapy of Prostate Cancer by BOCCARDO, F, RUBAGOTTI, A, ZATTONI, F, MACCHIARELLA, A, SIRAGUSA, A, MUSCAS, G, DURAND, F, POTENZONI, D, MANGANELLI, A, FERRARIS, V, MONTEFIORE, F, BATTAGLIA, M, DI TONNO, P, SELVAGGI, F. P, CONTI, G, COMERI, G, BERTACCINI, A, MARTORANA, G, GALASSI, P

“…To determine whether tamoxifen or anastrozole prevents gynecomastia and breast pain caused by bicalutamide (150 mg) without compromising efficacy, safety, or…”
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Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1 by SELTZER, Meghan J, BENNETT, Bryson D, DANG, Chi V, RIGGINS, Gregory J, JOSHI, Avadhut D, PING GAO, THOMAS, Ajit G, FERRARIS, Dana V, TSUKAMOTO, Takashi, ROJAS, Camilo J, SLUSHER, Barbara S, RABINOWITZ, Joshua D

“…Mutation at the R132 residue of isocitrate dehydrogenase 1 (IDH1), frequently found in gliomas and acute myelogenous leukemia, creates a neoenzyme that…”
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Parental Intentions and Perceptions Toward COVID-19 Vaccination Among Children Aged 4 Months to 4 Years — PROTECT Cohort, Four States, July 2021–May 2022 by Lutrick, Karen, Fowlkes, Ashley, Rivers, Patrick, Herder, Katherine, Santibanez, Tammy A, LeClair, Lindsay, Groover, Kimberly, Lamberte, Julie Mayo, Grant, Lauren, Odame-Bamfo, Leah, Ferraris, Maria V, Phillips, Andrew L, Sokol, Brian, Lowe, Ashley A, Mathenge, Clare, Pubillones, Felipe A, Cottam, Brianna, McLeland-Wieser, Hilary, Jovel, Krystal S, Ochoa, Jezahel S, Mckell, Jacob, Berry, Mark, Khan, Sana, Solle, Natasha Schaefer, Rai, Ramona P, Nakayima, Flavia Miiro, Newes-Adeyi, Gabriella, Porter, Cynthia, Baccam, Zoe, Ellingson, Katherine D, Burgess, Jeffery L, Gaglani, Manjusha, Gwynn, Lisa, Caban-Martinez, Alberto, Yoon, Sarang

“…What is already known on this topic? In June 2022, COVID-19 vaccines were authorized for use in children aged 6 months–5 years. Intent to vaccinate and…”
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Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors by Shukla, Krupa, Ferraris, Dana V., Thomas, Ajit G., Stathis, Marigo, Duvall, Bridget, Delahanty, Greg, Alt, Jesse, Rais, Rana, Rojas, Camilo, Gao, Ping, Xiang, Yan, Dang, Chi V., Slusher, Barbara S., Tsukamoto, Takashi

“…Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) that has…”
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16: Sex Differences in Platelet Activation in Patients With Acute Coronary Syndromes by Wehner, P, Charles, M, Ferraris, S, Ferraris, V

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Synthesis of substituted 5[ H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors by Li, Jia-He, Serdyuk, Larisa, Ferraris, Dana V., Xiao, Ge, Tays, Kevin L., Kletzly, Paul W., Li, Weixing, Lautar, Susan, Zhang, Jie, Kalish, Vincent J.

“…1-, 2-, 3-, 4-, 8-, or 10-Substituted 5( H)phenanthridin-6-ones were synthesized and found to be potent PARP1 inhibitors. Among the 28 compounds prepared, some…”
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Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors by Barinka, Cyril, Novakova, Zora, Hin, Niyada, Bím, Daniel, Ferraris, Dana V., Duvall, Bridget, Kabarriti, Gabriel, Tsukamoto, Reiji, Budesinsky, Milos, Motlova, Lucia, Rojas, Camilo, Slusher, Barbara S., Rokob, Tibor András, Rulíšek, Lubomír, Tsukamoto, Takashi

“…[Display omitted] A series of carbamate-based inhibitors of glutamate carboxypeptidase II (GCPII) were designed and synthesized using ZJ-43,…”
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Isolated and complete traumatic rupture of the pancreas: A case report and a review of the literature by Viti, M, Papis, D, Ferraris, V, Fiori, F, D’Urbano, C

“…Abstract INTRODUCTION Pancreatic trauma without injuries to other organs is uncommon, as reported in the reviewed literature. Diagnosis of pancreatic trauma…”
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Operative Outcome And Hospital Cost by Ferraris, Victor A., Ferraris, Suellen P., Singh, Amandeep

“…Introduction: Because of concern about increasing health care costs, we undertook a study to find patient risk factors associated with increased hospital costs…”
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δ‑Thiolactones as Prodrugs of Thiol-Based Glutamate Carboxypeptidase II (GCPII) Inhibitors by Ferraris, Dana V, Majer, Pavel, Ni, Chiyou, Slusher, C. Ethan, Rais, Rana, Wu, Ying, Wozniak, Krystyna M, Alt, Jesse, Rojas, Camilo, Slusher, Barbara S, Tsukamoto, Takashi

“…δ-Thiolactones derived from thiol-based glutamate carboxypeptidase II (GCPII) inhibitors were evaluated as prodrugs. In rat liver microsomes,…”
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