Search Results - "FERRARI, Guido"

Curing HIV: Seeking to Target and Clear Persistent Infection by Margolis, David M., Archin, Nancie M., Cohen, Myron S., Eron, Joseph J., Ferrari, Guido, Garcia, J. Victor, Gay, Cynthia L., Goonetilleke, Nilu, Joseph, Sarah B., Swanstrom, Ronald, Turner, Anne-Marie W., Wahl, Angela

“…Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic…”
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Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial by Haynes, Barton F, Gilbert, Peter B, McElrath, M. Juliana, Zolla-Pazner, Susan, Tomaras, Georgia D, Alam, S. Munir, Evans, David T, Montefiori, David C, Karnasuta, Chitraporn, Sutthent, Ruengpueng, Liao, Hua-Xin, DeVico, Anthony L, Lewis, George K, Williams, Constance, Pinter, Abraham, Fong, Youyi, Janes, Holly, DeCamp, Allan, Huang, Yunda, Rao, Mangala, Billings, Erik, Karasavvas, Nicos, Robb, Merlin L, Ngauy, Viseth, de Souza, Mark S, Paris, Robert, Ferrari, Guido, Bailer, Robert T, Soderberg, Kelly A, Andrews, Charla, Berman, Phillip W, Frahm, Nicole, De Rosa, Stephen C, Alpert, Michael D, Yates, Nicole L, Shen, Xiaoying, Koup, Richard A, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Michael, Nelson L, Kim, Jerome H

“…This analysis of correlates of the risk of HIV-1 infection in the RV144 vaccine trial identifies hypotheses for improving efficacy. The data indicate key roles…”
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Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency by Bradley, Todd, Ferrari, Guido, Haynes, Barton F., Margolis, David M., Browne, Edward P.

“…A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We…”
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Sustainable Tourism Destinations by Mondéjar-Jiménez, José, Ferrari, Guido

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Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity by Veillette, Maxime, Désormeaux, Anik, Medjahed, Halima, Gharsallah, Nour-Elhouda, Coutu, Mathieu, Baalwa, Joshua, Guan, Yongjun, Lewis, George, Ferrari, Guido, Hahn, Beatrice H., Haynes, Barton F., Robinson, James E., Kaufmann, Daniel E., Bonsignori, Mattia, Sodroski, Joseph, Finzi, Andrés

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Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG by Tomaras, Georgia D., Ferrari, Guido, Shen, Xiaoying, Alam, S. Munir, Liao, Hua-Xin, Pollara, Justin, Bonsignori, Mattia, Moody, M. Anthony, Fong, Youyi, Chen, Xi, Poling, Brigid, Nicholson, Cindo O., Zhang, Ruijun, Lu, Xiaozhi, Parks, Robert, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Gilbert, Peter B., Kim, Jerome H., Michael, Nelson L., Montefiori, David C., Haynes, Barton F.

“…Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable…”
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Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies by Chu, Thach H, Crowley, Andrew R, Backes, Iara, Chang, Cheryl, Tay, Matthew, Broge, Thomas, Tuyishime, Marina, Ferrari, Guido, Seaman, Michael S, Richardson, Simone I, Tomaras, Georgia D, Alter, Galit, Leib, David, Ackerman, Margaret E

“…Antibody functions such as neutralization require recognition of antigen by the Fab region, while effector functions are additionally mediated by interactions…”
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An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum by FERRARI, Guido, POLLARA, Justin, KAPPES, John C, SHAW, George M, HOXIE, James A, ROBINSON, James E, HAYNES, Barton F, KOZINK, Daniel, HARMS, Tiara, DRINKER, Mark, FREEL, Stephanie, MOODY, M. Anthony, MUNIR ALAM, S, TOMARAS, Georgia D, OCHSENBAUER, Christina

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1 by Jain, Swati, Uritskiy, Gherman, Mahalingam, Marthandan, Batra, Himanshu, Chand, Subhash, Trinh, Hung V, Beck, Charles, Shin, Woong-Hee, Alsalmi, Wadad, Kijak, Gustavo, Eller, Leigh A, Kim, Jerome, Kihara, Daisuke, Tovanabutra, Sodsai, Ferrari, Guido, Robb, Merlin L, Rao, Mangala, Rao, Venigalla B

“…A productive HIV-1 infection in humans is often established by transmission and propagation of a single transmitted/founder (T/F) virus, which then evolves…”
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Antibodies with High Avidity to the gp120 Envelope Protein in Protection from Simian Immunodeficiency Virus SIVmac251 Acquisition in an Immunization Regimen That Mimics the RV-144 Thai Trial by Pegu, Poonam, Vaccari, Monica, Gordon, Shari, Keele, Brandon F, Doster, Melvin, Guan, Yongjun, Ferrari, Guido, Pal, Ranajit, Ferrari, Maria Grazia, Whitney, Stephen

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Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection by GANUSOV, Vitaly V, GOONETILLEKE, Nilu, LIU, Michael K. P, FERRARI, Guido, SHAW, George M, MCMICHAEL, Andrew J, BORROW, Persephone, KORBER, Bette T, PERELSON, Alan S

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High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers by Lambotte, Olivier, Pollara, Justin, Boufassa, Faroudy, Moog, Christiane, Venet, Alain, Haynes, Barton F, Delfraissy, Jean-François, Saez-Cirion, Asier, Ferrari, Guido

“…The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We…”
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A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies by Ding, Shilei, Veillette, Maxime, Coutu, Mathieu, Prévost, Jérémie, Scharf, Louise, Bjorkman, Pamela J, Ferrari, Guido, Robinson, James E, Stürzel, Christina, Hahn, Beatrice H, Sauter, Daniel, Kirchhoff, Frank, Lewis, George K, Pazgier, Marzena, Finzi, Andrés

“…Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These…”
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Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk by Andersen-Nissen, Erica, Fiore-Gartland, Andrew, Ballweber Fleming, Lamar, Carpp, Lindsay N, Naidoo, Anneta F, Harper, Michael S, Voillet, Valentin, Grunenberg, Nicole, Laher, Fatima, Innes, Craig, Bekker, Linda-Gail, Kublin, James G, Huang, Ying, Ferrari, Guido, Tomaras, Georgia D, Gray, Glenda, Gilbert, Peter B, McElrath, M Juliana

“…The pox-protein regimen tested in the RV144 trial is the only vaccine strategy demonstrated to prevent HIV-1 infection. Subsequent analyses identified antibody…”
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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions by Pierre, Camille N, Adams, Lily E, Higgins, Jaclyn S, Anasti, Kara, Goodman, Derrick, Mielke, Dieter, Stanfield-Oakley, Sherry, Powers, John M, Li, Dapeng, Rountree, Wes, Wang, Yunfei, Edwards, Robert J, Alam, S Munir, Ferrari, Guido, Tomaras, Georgia D, Haynes, Barton F, Baric, Ralph S, Saunders, Kevin O

“…Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed…”
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Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1 by Lewis, George K, Ackerman, Margaret E, Scarlatti, Gabriella, Moog, Christiane, Robert-Guroff, Marjorie, Kent, Stephen J, Overbaugh, Julie, Reeves, R Keith, Ferrari, Guido, Thyagarajan, Bargavi

“…It is now well-accepted that Fc-mediated effector functions, including antibody-dependent cellular cytotoxicity (ADCC), can contribute to vaccine-elicited…”
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Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques by Pardi, Norbert, LaBranche, Celia C., Ferrari, Guido, Cain, Derek W., Tombácz, István, Parks, Robert J., Muramatsu, Hiromi, Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Polacino, Patricia, Barbosa, Christopher J., Madden, Thomas D., Hope, Michael J., Haynes, Barton F., Montefiori, David C., Hu, Shiu-Lok, Weissman, Drew

“…Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in…”
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Safety and Immunogenicity of a DNA Vaccine With Subtype C gp120 Protein Adjuvanted With MF59 or AS01B: A Phase 1/2a HIV-1 Vaccine Trial by Garrett, Nigel, Dintwe, One, Monaco, Cynthia L, Jones, Megan, Seaton, Kelly E, Church, E Chandler, Grunenberg, Nicole, Hutter, Julia, deCamp, Allan, Huang, Yunda, Lu, Huiyin, Mann, Philipp, Robinson, Samuel T, Heptinstall, Jack, Jensen, Ryan L, Pantaleo, Giuseppe, Ding, Song, Koutsoukos, Marguerite, Hosseinipour, Mina C, Van Der Meeren, Olivier, Gilbert, Peter B, Ferrari, Guido, Andersen-Nissen, Erica, McElrath, M Juliana, Tomaras, Georgia D, Gray, Glenda E, Corey, Lawrence, Kublin, James G

“…An effective vaccine is required to end the HIV pandemic. We evaluated the safety and immunogenicity of a DNA (DNA-HIV-PT123) vaccine with low- or high-dose…”
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Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models by Pollara, Justin, Jones, Dorothy I, Huffman, Tori, Edwards, R Whitney, Dennis, Maria, Li, Shuk Hang, Jha, Shalini, Goodman, Derrick, Kumar, Amit, LaBranche, Celia C, Montefiori, David C, Fouda, Genevieve G, Hope, Thomas J, Tomaras, Georgia D, Staats, Herman F, Ferrari, Guido, Permar, Sallie R

“…Studies in animal models are essential prerequisites for clinical trials of candidate HIV vaccines. Small animals, such as rabbits, are used to evaluate…”
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FlowKit: A Python Toolkit for Integrated Manual and Automated Cytometry Analysis Workflows by White, Scott, Quinn, John, Enzor, Jennifer, Staats, Janet, Mosier, Sarah M, Almarode, James, Denny, Thomas N, Weinhold, Kent J, Ferrari, Guido, Chan, Cliburn

“…An important challenge for primary or secondary analysis of cytometry data is how to facilitate productive collaboration between domain and quantitative…”
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