Search Results - "FERGUSSON, Dean A"

Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion by Carson, Jeffrey L, Stanworth, Simon J, Roubinian, Nareg, Fergusson, Dean A, Triulzi, Darrell, Doree, Carolyn, Hebert, Paul C

“…There is considerable uncertainty regarding the optimal haemoglobin threshold for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a…”
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Patient-reported outcomes and target effect sizes in pragmatic randomized trials in ClinicalTrials.gov: A cross-sectional analysis by Vanderhout, Shelley, Fergusson, Dean A, Cook, Jonathan A, Taljaard, Monica

“…Use of patient-reported outcomes (PROs) and patient and public engagement are critical ingredients of pragmatic trials, which are intended to be patient…”
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An Analysis of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Preclinical Use by Tieu, Alvin, Lalu, Manoj M, Slobodian, Mitchell, Gnyra, Catherine, Fergusson, Dean A, Montroy, Joshua, Burger, Dylan, Stewart, Duncan J, Allan, David S

“…Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can reduce inflammation, promote healing, and improve organ function, thereby providing a…”
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Age of Transfused Blood in Critically Ill Adults by Lacroix, Jacques, Hébert, Paul C, Fergusson, Dean A, Tinmouth, Alan, Cook, Deborah J, Marshall, John C, Clayton, Lucy, McIntyre, Lauralyn, Callum, Jeannie, Turgeon, Alexis F, Blajchman, Morris A, Walsh, Timothy S, Stanworth, Simon J, Campbell, Helen, Capellier, Gilles, Tiberghien, Pierre, Bardiaux, Laurent, van de Watering, Leo, van der Meer, Nardo J, Sabri, Elham, Vo, Dong

“…In a trial involving more than 2400 critically ill patients, 90-day mortality was similar among patients receiving blood donated on average 6 days earlier and…”
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Renin-Angiotensin System Blockade and Long-term Clinical Outcomes in Kidney Transplant Recipients: A Meta-analysis of Randomized Controlled Trials by Hiremath, Swapnil, MD, Fergusson, Dean A., PhD, Fergusson, Nicholas, BSc, Bennett, Alexandria, BSc, Knoll, Greg A., MD

“…Background Renin-angiotensin system [RAS] blockade has been established as the cornerstone of therapy in the general population, and especially in chronic…”
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The Risks and Benefits of Cavernous Neurovascular Bundle Sparing during Radical Prostatectomy: A Systematic Review and Meta-Analysis by Nguyen, Laura N., Head, Linden, Witiuk, Kelsey, Punjani, Nahid, Mallick, Ranjeeta, Cnossen, Sonya, Fergusson, Dean A., Cagiannos, Ilias, Lavallée, Luke T., Morash, Christopher, Breau, Rodney H.

“…We summarize published data on associations between cavernous neurovascular bundle preservation (nerve sparing) during prostatectomy and positive surgical…”
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Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial by McIntyre, Lauralyn A, Stewart, Duncan J, Mei, Shirley H J, Courtman, David, Watpool, Irene, Granton, John, Marshall, John, Dos Santos, Claudia, Walley, Keith R, Winston, Brent W, Schlosser, Kenny, Fergusson, Dean A

“…In septic animal models mesenchymal stem (stromal) cells (MSCs) modulate inflammation, enhance tissue repair and pathogen clearance, and reduce death. To…”
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The prevalence of non-contrast CT imaging abnormalities in reversible cerebral vasoconstriction syndrome: A systematic review and meta-analysis by Gotesman, Ryan Daniel, Niznick, Naomi, Dewar, Brian, Fergusson, Dean A, Mallick, Ranjeeta, Shorr, Risa, Shamy, Michel, Dowlatshahi, Dar

“…Reversible cerebral vasoconstriction syndrome (RCVS) is a syndrome of recurrent thunderclap headaches and reversible vasoconstriction of the cerebral arteries…”
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From the Lab to Patients: a Systematic Review and Meta-Analysis of Mesenchymal Stem Cell Therapy for Stroke by Lalu, Manoj M., Montroy, Joshua, Dowlatshahi, Dar, Hutton, Brian, Juneau, Pascale, Wesch, Neil, Y. Zhang, Sarah, McGinn, Ryan, Corbett, Dale, Stewart, Duncan J., A. Fergusson, Dean

“…There may be the potential to improve stroke recovery with mesenchymal stem cells (MSCs); however, questions about the efficacy and safety of this treatment…”
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A systematic review and meta-analysis of pregabalin preclinical studies by Federico, Carole A., Mogil, Jeffrey S., Ramsay, Tim, Fergusson, Dean A., Kimmelman, Jonathan

“…Despite large efforts to test analgesics in animal models, only a handful of new pain drugs have shown efficacy in patients. Here, we report a systematic…”
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Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies by Corrales-Medina, Vicente F, Suh, Kathryn N, Rose, Gregory, Chirinos, Julio A, Doucette, Steve, Cameron, D William, Fergusson, Dean A

“…Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. CAP can trigger acute cardiac events. We sought to determine the incidence of…”
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Interventions to improve resilience in physicians who have completed training: A systematic review by Venegas, Carolina Lavin, Nkangu, Miriam N, Duffy, Melissa C, Fergusson, Dean A, Spilg, Edward G

“…Resilience is a contextual phenomenon where a complex and dynamic interplay exists between individual, environmental, and socio-cultural factors. With growing…”
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Cough augmentation techniques for extubation or weaning critically ill patients from mechanical ventilation by Rose, Louise, Adhikari, Neill Kj, Leasa, David, Fergusson, Dean A, McKim, Douglas

“…There are various reasons why weaning and extubation failure occur, but ineffective cough and secretion retention can play a significant role. Cough…”
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A call to implement preclinical study registration in animal ethics review by Jeffers, Matthew S, MacLellan, Aileen, Avey, Marc T, Menon, Julia ML, Sunohara-Neilson, Janet, Fergusson, Dean A, Lalu, Manoj M

“…Protocol registration is required in clinical trials. Registration of animal studies could improve research transparency and reduce redundancy, yet uptake has…”
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Safety and Efficacy of Adult Stem Cell Therapy for Acute Myocardial Infarction and Ischemic Heart Failure (SafeCell Heart): A Systematic Review and Meta‐Analysis by Lalu, Manoj M., Mazzarello, Sasha, Zlepnig, Jennifer, Dong, Yuan Yi (Ryan), Montroy, Joshua, McIntyre, Lauralyn, Devereaux, P.J., Stewart, Duncan J., David Mazer, C., Barron, Carly C., McIsaac, Daniel I., Fergusson, Dean A.

“…Preclinical and clinical evidence suggests that mesenchymal stem cells (MSCs) may be beneficial in treating both acute myocardial infarction (AMI) and ischemic…”
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A qualitative evaluation of treatment fidelity alongside a pilot trial of a novel therapy for pediatric Inflammatory Bowel Disease by Olson, Jenny L, Castillo, Gisell, Palumbo, Amelia, Harrison, Megan, Singleton, Ruth, Lalu, Manoj M, Fergusson, Dean A, Stintzi, Alain, Mack, David R, Presseau, Justin

“…Process evaluations conducted alongside clinical trials can improve understanding of treatment fidelity and provide contextual knowledge to aide…”
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Efficacy of Mesenchymal Stromal Cell Therapy for Acute Lung Injury in Preclinical Animal Models: A Systematic Review by McIntyre, Lauralyn A, Moher, David, Fergusson, Dean A, Sullivan, Katrina J, Mei, Shirley H J, Lalu, Manoj, Marshall, John, Mcleod, Malcolm, Griffin, Gilly, Grimshaw, Jeremy, Turgeon, Alexis, Avey, Marc T, Rudnicki, Michael A, Jazi, Mazen, Fishman, Jason, Stewart, Duncan J

“…The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical condition that is associated with a 30-40% risk of death, and significant long term…”
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Synthesizing regulatory guidance for demonstrating preclinical efficacy and translating promising cell therapies to early phase clinical trials: a scoping review by Jeffers, Matthew S, Xi, Cheng En, Bapuji, Raj, Wotherspoon, Hannah, Kimmelman, Jonathan, Bedford, Patrick, McIsaac, Daniel I, Lalu, Manoj M, Fergusson, Dean A

“…Regulatory applications for cell therapy face more objections compared to conventional small molecule or biological drugs, leading to delays in market approval…”
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Prevention of contrast-induced acute kidney injury: is simple oral hydration similar to intravenous? A systematic review of the evidence by Hiremath, Swapnil, Akbari, Ayub, Shabana, Wael, Fergusson, Dean A, Knoll, Greg A

“…Pre-procedural intravenous fluid administration is an effective prophylaxis measure for contrast-induced acute kidney injury. For logistical ease, the oral…”
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Treatment of Polyomavirus Infection in Kidney Transplant Recipients: A Systematic Review by JOHNSTON, Olwyn, JASWAL, Dharmvir, GILL, John S, DOUCETTE, Steve, FERGUSSON, Dean A, KNOLL, Greg A

“…BACKGROUND.: Polyomavirus-associated nephropathy (PVAN) is an important cause of kidney graft loss but there is no consensus on its management. This study…”
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