Search Results - "FERGUSON, Michelle"

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells by Vaidyanathan, Aparajitha, Sawers, Lynne, Gannon, Anne-Louise, Chakravarty, Probir, Scott, Alison L, Bray, Susan E, Ferguson, Michelle J, Smith, Gillian

“…Background: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying…”
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Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer by Nicholson, Hugh A., Sawers, Lynne, Clarke, Rosemary G., Hiom, Kevin J., Ferguson, Michelle J., Smith, Gillian

“…Background Ovarian cancer patients frequently develop chemotherapy resistance, limiting treatment options. We have previously shown that individuality in…”
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A Phase 1/2 Trial of Brief Androgen Suppression and Stereotactic Radiation Therapy (FASTR) for High-Risk Prostate Cancer by Bauman, Glenn, MD, Ferguson, Michelle, MD, Lock, Michael, MD, Chen, Jeff, PhD, Ahmad, Belal, MD, Venkatesan, V.M., MD, Sexton, Tracy, MD, PhD, D'Souza, David, MD, Loblaw, Andrew, MD, Warner, Andrew, MSc, Rodrigues, George, MD, PhD

“…Purpose To initiate a phase 1/2 trial to examine the tolerability of a condensed combined-modality protocol for high-risk prostate cancer. Methods and…”
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Virtual Reality-Based Resilience Programs: Feasibility and Implementation for Inpatient Oncology Nurses by Michael, Sarah H, Villarreal, Pamela M, Ferguson, Michelle F, Wiler, Jennifer L, Zane, Richard D, Flarity, Kathleen

“…The high prevalence of compassion fatigue contributes to burnout among oncology nurses. Interventions are needed to support individuals across diverse roles…”
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Increased Incidence of Visceral Metastases in Scottish Patients With BRCA1/2-Defective Ovarian Cancer: An Extension of the Ovarian BRCAness Phenotype by GOURLEY, Charlie, MICHIE, Caroline O, HAYWARD, Richard L, MITCHELL, Paul, RYE, Tzyvia, SCHELLENS, Jan H. M, LUBINSKI, Jan, CARMICHAEL, James, KAYE, Stan B, MACKEAN, Melanie, FERGUSON, Michelle, ROXBURGH, Patricia, YAP, TimothyA, HARDEN, Sharon, PAUL, Jim, RAGUPATHY, Kalpana, TODD, Radha, PETTY, Russell, REED, Nick

“…To compare the frequency of visceral relapse of BRCA1/2-deficient ovarian cancer to that of nonhereditary controls. All patients diagnosed in Scotland with…”
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What Matters to Us: Impact of Telemedicine During the Pandemic in the Care of Patients With Sarcoma Across Scotland by McCabe, Holly M, Smrke, Alannah, Cowie, Fiona, White, Jeff, Chong, Peter, Lo, Steven, Mahendra, Ashish, Gupta, Sanjay, Ferguson, Michelle, Boddie, David, Mmekka, Walter, Stirling, Lorraine, Campbell, Lindsay, Jones, Robin L, Nixon, Ioanna

“…In Scotland, approximately 350 sarcoma cases are diagnosed per year and treated in one of the five specialist centers. Many patients are required to travel…”
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Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer by Spratt, Daniel E, Tang, Siyi, Sun, Yilun, Huang, Huei-Chung, Chen, Emmalyn, Mohamad, Osama, Armstrong, Andrew J, Tward, Jonathan D, Nguyen, Paul L, Lang, Joshua M, Zhang, Jingbin, Mitani, Akinori, Simko, Jeffry P, DeVries, Sandy, van der Wal, Douwe, Pinckaers, Hans, Monson, Jedidiah M, Campbell, Holly A, Wallace, James, Ferguson, Michelle J, Bahary, Jean-Paul, Schaeffer, Edward M, Sandler, Howard M, Tran, Phuoc T, Rodgers, Joseph P, Esteva, Andre, Yamashita, Rikiya, Feng, Felix Y

“…BACKGROUND: Androgen deprivation therapy (ADT) with radiotherapy can benefit patients with localized prostate cancer. However, ADT can negatively impact…”
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Management of High-Grade Gliomas in the Elderly by Ferguson, Michelle, MD, FRCPC, Rodrigues, George, MD, PhD, FRCPC, Cao, Jeffrey, MD, MBA, FRCPC, Bauman, Glenn, MD, FRCPC

“…The incidence of glioblastoma (GBM) has been increasing over the past several decades with majority of this increase occurring in patients older than 70 years…”
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Pembrolizumab monotherapy for non-small cell lung cancer (NSCLC): can patient stratification be improved in the UK Tayside population? A retrospective cohort study by Mander, Emily Susannah, Merrick, Christopher Brian, Nicholson, Hugh Adam, Lord, Hannah Kate, Ferguson, Michelle Jane, Smith, Gillian

“…ObjectivePembrolizumab is a programmed cell death protein-1 (PD-1) inhibitor used to treat advanced patients with non-small cell lung cancer (NSCLC) with a…”
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Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo by SPRUCE, Barbara A, CAMPBELL, Lorna A, MCLEAN, Doris, LESLIE, Nick R, SAFRANY, Stephen T, FERGUSON, Michelle J, PETERS, John A, PRESCOTT, Alan R, BOX, Gary, HAYES, Angela, NUTLEY, Bernard, RAYNAUD, Florence, MCTAVISH, Niall, DOWNES, C. Peter, LAMBERT, Jeremy J, THOMPSON, Alastair M, ECCLES, Suzanne, COOPER, Michelle A, APPLEYARD, M. Virginia L, O'NEILL, Mary, HOWIE, Jacqueline, SAMSON, Jayne, WATT, Stephen, MURRAY, Karen

“…The acquisition of resistance to apoptosis, the cell's intrinsic suicide program, is essential for cancers to arise and progress and is a major reason behind…”
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Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials by Esteva, Andre, Feng, Jean, van der Wal, Douwe, Huang, Shih-Cheng, Simko, Jeffry P., DeVries, Sandy, Chen, Emmalyn, Schaeffer, Edward M., Morgan, Todd M., Sun, Yilun, Ghorbani, Amirata, Naik, Nikhil, Nathawani, Dhruv, Socher, Richard, Michalski, Jeff M., Roach, Mack, Pisansky, Thomas M., Monson, Jedidiah M., Naz, Farah, Wallace, James, Ferguson, Michelle J., Bahary, Jean-Paul, Zou, James, Lungren, Matthew, Yeung, Serena, Ross, Ashley E., Sandler, Howard M., Tran, Phuoc T., Spratt, Daniel E., Pugh, Stephanie, Feng, Felix Y., Mohamad, Osama

“…Prostate cancer is the most frequent cancer in men and a leading cause of cancer death. Determining a patient’s optimal therapy is a challenge, where…”
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The Value in Mental Health Screening for Individuals With Spinal Cord Injury: What Patients Tell Us by McMillan, Colleen, Lee, Joseph, Hillier, Loretta M., Milligan, James, Lee, Linda, Bauman, Craig, Ferguson, Michelle, Slonim, Karen, Weber, Kay

“…To gather consumer perspectives of a mental health screening protocol and to identify the incidence of previously unrecognized mental health concerns (case…”
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Author Correction: Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials by Esteva, Andre, Feng, Jean, van der Wal, Douwe, Huang, Shih-Cheng, Simko, Jeffry P., DeVries, Sandy, Chen, Emmalyn, Schaeffer, Edward M., Morgan, Todd M., Sun, Yilun, Ghorbani, Amirata, Naik, Nikhil, Nathawani, Dhruv, Socher, Richard, Michalski, Jeff M., Roach, Mack, Pisansky, Thomas M., Monson, Jedidiah M., Naz, Farah, Wallace, James, Ferguson, Michelle J., Bahary, Jean-Paul, Zou, James, Lungren, Matthew, Yeung, Serena, Ross, Ashley E., Sandler, Howard M., Tran, Phuoc T., Spratt, Daniel E., Pugh, Stephanie, Feng, Felix Y., Mohamad, Osama

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Late-Onset Meningeal Metastases in Liposarcoma: A Case Report and Review of the Literature by Ferguson, Michelle, Stewart, William, Cowie, Fiona, White, Jeff

“…Intracranial metastases from liposarcoma are rare and almost always preceded by the development of systemic tumour spread. We report here a case of liposarcoma…”
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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials by Vergote, Ignace, Coens, Corneel, Nankivell, Matthew, Kristensen, Gunnar B, Parmar, Mahesh K B, Jayson, Gordon C, Swart, Ann Marie, Verheijen, René, McCluggage, W Glenn, Perren, Tim, Panici, Pierluigi Benedetti, Kenter, Gemma, Casado, Antonio, Mendiola, Cesar, Stuart, Gavin, Reed, Nick S, Kehoe, Sean, Tropé G., Claes, Dobbs, Stephen, Essapen, Sharadah, Hoskins, P., Van Baal, M., Twigg, Jeremy, Van Der Burg, Maria E.L., Godfrey, Keith, Lacave, Angel J., Redman, Charles, Lotocki, R., Olaitan, Adeola, Mosgaard, B., Rustin, G., Persic, Mojca, Hogg, Martin, Van Der Velden, J., Ledermann, J., Peter Sykes, Peter Sykes, Hird, Vicky, Sandvei R., R., Cruickshank, D.J., Ottevanger, P.B., Pearson, Sheila, Hall, Marcia, Bessette, P., Gerdin, E., Lopes, Tito, Fish, Andrew, Van Eygen, K., Floquet, A., Tholander, B., Gul, N., Gornall, Robert, Luesley, David, Symonds, Paul, Poole, David, McNeish, Ian, Hocking, Mark, Sammaraie, Al, Speiser, P., Leblanc, E., De Oliveira, C.F., Grimshaw, R., Zola, P., Parkin, David, Lamb, Martin, Gillespie, Alan, Hamid, Abdel, Ahmed, Ahmed, Perez, David, Skailes, Geraldine, Jones, Rachel, Leeson, Simon, Elit, L., Gotlieb, W., Crosse, Barbara, Ridley, Paul, Head, Anthony, Nieto, Joaquin, Awwad, Saif, Brinkmann, Dirk, Eustace, Damian, Katsaros, D., Popadiuk, C., Redman, C., Chan, S., Marth, C., Lankaster, Kate, Indrajit, Fernando, Quigley, Mary, Adeyemi, Olu, McNally, Orla, Tristam, Amanda, Lee, Martin, Counsell, R., Gleeson, N., Papadopoulos, A., Maggino, T., Ghatage, P., Vermorken, J.B., Petru, E, Amant, F.

“…Individual patient data from two randomised trials comparing neoadjuvant chemotherapy with upfront debulking surgery in advanced tubo-ovarian cancer were…”
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The Development of a CDK2-Docking Site Peptide that Inhibits p53 and Sensitizes Cells to Death by Ferguson, Michelle, Luciani, M.Gloria, Finlan, Lee, Ibbotson, Sally, Fersht, Alan, Hupp, Ted R.

“…Cyclin-dependent protein kinases play important roles in cell cycle progression and are attractive targets for the design of anti-proliferative drugs. Two…”
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Olaparib plus Durvalumab, with or without Bevacizumab, as Treatment in PARP Inhibitor-Naïve Platinum-Sensitive Relapsed Ovarian Cancer: A Phase II Multi-Cohort Study by Drew, Yvette, Kim, Jae-Weon, Penson, Richard T, O'Malley, David M, Parkinson, Christine, Roxburgh, Patricia, Plummer, Ruth, Im, Seock-Ah, Imbimbo, Martina, Ferguson, Michelle, Rosengarten, Ora, Steeghs, Neeltje, Kim, Min Hwan, Gal-Yam, Einav, Tsoref, Daliah, Kim, Jae-Hoon, You, Benoit, De Jonge, Maja, Lalisang, Roy, Gort, Eelke, Bastian, Sara, Meyer, Kassondra, Feeney, Laura, Baker, Nigel, Ah-See, Mei-Lin, Domchek, Susan M, Banerjee, Susana

“…Early results from the phase II MEDIOLA study (NCT02734004) in germline BRCA1- and/or BRCA2-mutated (gBRCAm) platinum-sensitive relapsed ovarian cancer (PSROC)…”
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Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma by Ewing, Ailith, Meynert, Alison, Churchman, Michael, Grimes, Graeme R, Hollis, Robert L, Herrington, C Simon, Rye, Tzyvia, Bartos, Clare, Croy, Ian, Ferguson, Michelle, Lennie, Mairi, McGoldrick, Trevor, McPhail, Neil, Siddiqui, Nadeem, Dowson, Suzanne, Glasspool, Rosalind, Mackean, Melanie, Nussey, Fiona, McDade, Brian, Ennis, Darren, McMahon, Lynn, Matakidou, Athena, Dougherty, Brian, March, Ruth, Barrett, J Carl, McNeish, Iain A, Biankin, Andrew V, Roxburgh, Patricia, Gourley, Charlie, Semple, Colin A

“…The abundance and effects of structural variation at BRCA1/2 in tumors are not well understood. In particular, the impact of these events on homologous…”
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Lewis Acid-Base, Molecular Modeling, and Isotopic Labeling in a Sophomore Inorganic Chemistry Laboratory by Nataro, Chip, Ferguson, Michaelle A, Bocage, Katherine M, Hess, Brian J, Ross, Vincent J, Swarr, Daniel T

“…Lewis acid–base theory is taught in most inorganic courses. These concepts are typically studied in the laboratory, usually by the formation of an adduct. The…”
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Abstract A74: Identification of novel targetable resistance mechanisms and candidate clinical response biomarkers in drug-resistant ovarian cancer, following single-agent and combination chemotherapy by Vaidyanathan, Aparajitha, Sawers, Lynne, Chakravarty, Probir, Bray, Susan E., McMullen, K. Wendy, Ferguson, Michelle J., Smith, Gillian

“…Abstract The aim of our translational research program in Dundee is to develop innovative experimental models to understand the molecular basis of adaptive…”
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