Search Results - "FENTEM, Julia H"

The 19th FRAME Annual Lecture, November 2022: Safer Chemicals and Sustainable Innovation Will Be Achieved by Regulatory Use of Modern Safety Science, Not by More Animal Testing by Fentem, Julia H.

“…The decisions we make on chemical safety, for consumers, workers and the environment, must be based on the best scientific data and knowledge available. Rapid…”
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ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test by Spielmann, Horst, Hoffmann, Sebastian, Liebsch, Manfred, Botham, Phil, Fentem, Julia H, Eskes, Chantra, Roguet, Roland, Cotovio, José, Cole, Thomas, Worth, Andrew, Heylings, Jon, Jones, Penny, Robles, Catherine, Kandárova, Helena, Gamer, Armin, Remmele, Marina

“…ECVAM sponsored a formal validation study on three in vitro tests for skin irritation, of which two employ reconstituted human epidermis models (EPISKIN,…”
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ECVAM's Activities in Validating Alternative Tests for Skin Corrosion and Irritation by Fentem, Julia H, Botham, Philip A

“…ECVAM has funded and managed validation studies on in vitro tests for skin corrosion, resulting in the validities of four in vitro tests being endorsed by the…”
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Working together to respond to the challenges of EU policy to replace animal testing by Fentem, J.H

“…This paper presents a personal perspective on efforts during the past 15 years to replace animal testing for assessing the safety of chemicals and products. It…”
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Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin Irritation. ECVAM Skin Irritation Task Force Report 2 by ZUANG, Valérie, BALLS, Michael, MEDINA, Jesus, ROGUET, Roland, VAN DE SANDT, Johannes J. M, WIEMANN, Christianne, WORTH, Andrew P, BOTHAM, Philip A, COQUETTE, Alain, CORSINI, Emanuela, CURREN, Rodger D, ELLIOTT, Graham R, FENTEM, Julia H, HEYLINGS, Jon R, LIEBSCH, Manfred

“…The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the…”
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Update on the validation and regulatory acceptance of alternative tests for skin corrosion and irritation by Fentem, Julia H, Botham, Philip A

“…The European Centre for the Validation of Alternative Methods (ECVAM) has supported validation studies on in vitro tests for skin corrosion, resulting in the…”
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The three Rs: the way forward: the report and recommendations of ECVAM Workshop 11 by Balls, Michael, Goldberg, Alan M, Fentem, Julia H, Broadhead, Caren L, Burch, Rex L, Festing, Michael F W, Frazier, John M, Hendriksen, Coenraad F M, Jennings, Margaret, van der Kamp, Margot D O, Morton, David B, Rowan, Andrew N, Russell, Claire, Russell, William M S, Spielmann, Horst, Stephens, Martin L, Stokes, William S, Straughan, Donald W, Yager, James D, Zurlo, Joanne, van Zutphen, Bert F M

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Comparative evaluation of five in vitro tests for assessing the eye irritation potential of hair-care products by JONES, Penny A, BUDYNSKY, Ella, COOPER, Karen J, DECKER, Denise, GRIFFITHS, Heather A, FENTEM, Julia H

“…This study compared five methods, the isolated rabbit eye (IRE), bovine corneal opacity and permeability (BCOP), EpiOcular, fluorescein leakage (FL) and…”
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Species differences in the metabolism and hepatotoxicity of coumarin by Fentem, J H, Fry, J R

“…1. Investigations of coumarin metabolism and hepatotoxicity have been reviewed. 2. Species differences in coumarin hepatotoxicity appear to be…”
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The Use of Human Tissues in In Vitro Toxicology, Stirling, 28/29 April 1993. Summary of general discussions by Fentem, J H

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Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds by Fry, J R, Fentem, J H, Salim, A, Tang, S P, Garle, M J, Whiting, D A

“…The interaction of glutathione (GSH) with coumarin, or one of a series of compounds related to coumarin, was assessed in the absence and presence of liver…”
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The ECVAM International Validation Study on In Vitro Tests for Acute Skin Irritation : Report on the Validity of the EPISKIN and EpiDerm Assays and on the Skin Integrity Function Testa by SPIELMANN, Horst, HOFFMANN, Sebastian, HEYLINGS, Jon, JONES, Penny, ROBLES, Catherine, KANDAROVA, Helena, GAMER, Armin, REMMELE, Marina, CURREN, Rodger, RAABE, Hans, COCKSHOTT, Amanda, GERNER, Ingrid, LIEBSCH, Manfred, ZUANG, Valérie, BOTHAM, Phil, FENTEM, Julia H, ESKES, Chantra, ROGUET, Roland, COTOVIO, José, COLE, Thomas, WORTH, Andrew

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Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin irritation. The European Centre for the Validation of Alternative Methods Skin Irritation Task Force report 2 by Zuang, Valérie, Balls, Michael, Botham, Philip A, Coquette, Alain, Corsini, Emanuela, Curren, Rodger D, Elliott, Graham R, Fentem, Julia H, Heylings, Jon R, Liebsch, Manfred, Medina, Jesús, Roguet, Roland, van de Sandt, Johannes J M, Wiemann, Christianne, Worth, Andrew P

“…The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the…”
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A general approach for evaluating stepwise testing strategies by WORTH, A. P, FENTEM, J. H

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Species differences in the hepatotoxicity of coumarin: a comparison of rat and Mongolian gerbil by Fentem, J H, Fry, J R, Thomas, N W

“…The acute hepatic effects of coumarin (2H-1-benzopyran-2-one) in male Wistar rats and Mongolian gerbils has been compared. A single dose of coumarin (125…”
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Effect of cimetidine on the metabolism of coumarin by rat, gerbil and human liver microsomes by Fentem, J H, Fry, J R

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Comparison of Mongolian gerbil and rat hepatic microsomal monooxygenase activities: high coumarin 7-hydroxylase activity in the gerbil by Dominguez, K, Fentem, J H, Garle, M J, Fry, J R

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