Search Results - "FELTWELL, Theresa"

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella by Bruchmann, Sebastian, Feltwell, Theresa, Parkhill, Julian, Short, Francesca L

“…ABSTRACT Infections caused by Klebsiella pneumoniae are a major public health threat. Extensively drug-resistant and even pan-resistant strains have been…”
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Genomic epidemiology of COVID-19 in care homes in the east of England by Hamilton, William L, Tonkin-Hill, Gerry, Smith, Emily R, Aggarwal, Dinesh, Houldcroft, Charlotte J, Warne, Ben, Meredith, Luke W, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Brown, Colin S, Gonçalves, Sonia, Amato, Roberto, Harrison, Ewan M, Brown, Nicholas M, Beale, Mathew A, Spencer Chapman, Michael, Jackson, David K, Johnston, Ian, Alderton, Alex, Sillitoe, John, Langford, Cordelia, Dougan, Gordon, Peacock, Sharon J, Kwiatowski, Dominic P, Goodfellow, Ian G, Torok, M Estee

“…COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167…”
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Complete Assembly of Escherichia coli Sequence Type 131 Genomes Using Long Reads Demonstrates Antibiotic Resistance Gene Variation within Diverse Plasmid and Chromosomal Contexts by Decano, Arun Gonzales, Ludden, Catherine, Feltwell, Theresa, Judge, Kim, Parkhill, Julian, Downing, Tim

“…The incidence of infections caused by extraintestinal (ExPEC) is rising globally, which is a major public health concern. ExPEC strains that are resistant to…”
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Population genetics of group B Streptococcus from maternal carriage in an ethnically diverse community in London by Jamrozy, Dorota, Gopal Rao, Guduru, Feltwell, Theresa, Lamagni, Theresa, Khanna, Priya, Efstratiou, Androulla, Parkhill, Julian, Bentley, Stephen D

“…Maternal immunization against Group B (GBS) has the potential to significantly reduce the burden of neonatal GBS infections. Population genetics of GBS from…”
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Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio by Gomes-Santos, Carina S S, Braks, Joanna, Prudêncio, Miguel, Carret, Céline, Gomes, Ana Rita, Pain, Arnab, Feltwell, Theresa, Khan, Shahid, Waters, Andrew, Janse, Chris, Mair, Gunnar R, Mota, Maria M

“…Many eukaryotic developmental and cell fate decisions that are effected post-transcriptionally involve RNA binding proteins as regulators of translation of key…”
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The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081 by Thomson, Nicholas R, Howard, Sarah, Wren, Brendan W, Holden, Matthew T G, Crossman, Lisa, Challis, Gregory L, Churcher, Carol, Mungall, Karen, Brooks, Karen, Chillingworth, Tracey, Feltwell, Theresa, Abdellah, Zahra, Hauser, Heidi, Jagels, Kay, Maddison, Mark, Moule, Sharon, Sanders, Mandy, Whitehead, Sally, Quail, Michael A, Dougan, Gordon, Parkhill, Julian, Prentice, Michael B

“…The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic…”
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What's in a Name? Species-Wide Whole-Genome Sequencing Resolves Invasive and Noninvasive Lineages of Salmonella enterica Serotype Paratyphi B by Connor, Thomas R, Owen, Sian V, Langridge, Gemma, Connell, Steve, Nair, Satheesh, Reuter, Sandra, Dallman, Timothy J, Corander, Jukka, Tabing, Kristine C, Le Hello, Simon, Fookes, Maria, Doublet, Benoît, Zhou, Zhemin, Feltwell, Theresa, Ellington, Matthew J, Herrera, Silvia, Gilmour, Matthew, Cloeckaert, Axel, Achtman, Mark, Parkhill, Julian, Wain, John, De Pinna, Elizabeth, Weill, François-Xavier, Peters, Tansy, Thomson, Nick

“…For 100 years, it has been obvious that Salmonella enterica strains sharing the serotype with the formula 1,4,[5],12:b:1,2-now known as Paratyphi B-can cause…”
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Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure by Mwai, Leah, Diriye, Abdi, Masseno, Victor, Muriithi, Steven, Feltwell, Theresa, Musyoki, Jennifer, Lemieux, Jacob, Feller, Avi, Mair, Gunnar R, Marsh, Kevin, Newbold, Chris, Nzila, Alexis, Carret, Céline K

“…The combination therapy of the Artemisinin-derivative Artemether (ART) with Lumefantrine (LM) (Coartem®) is an important malaria treatment regimen in many…”
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Complete Genome of Acute Rheumatic Fever-Associated Serotype M5 Streptococcus pyogenes Strain Manfredo by HOLDEN, Matthew T. G, SCOTT, Annabel, JAGELS, Kay, MOULE, Sharon, MUNGALL, Karen, QUAIL, Michael A, PRICE, Claire, RABBINOWITSCH, Ester, SHARP, Sarah, SKELTON, Jason, WHITEHEAD, Sally, BARRELL, Bart G, CHEREVACH, Inna, KEHOE, Michael, PARKHILL, Julian, CHILLINGWORTH, Tracey, CHURCHER, Carol, CRONIN, Ann, DOWD, Linda, FELTWELL, Theresa, HAMLIN, Nancy, HOLROYD, Simon

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes by Dillon, Gary P, Feltwell, Theresa, Skelton, Jason, Coulson, Patricia S, Wilson, R Alan, Ivens, Alasdair C

“…Schistosome cercariae only elicit high levels of protective immunity against a challenge infection if they are optimally attenuated by exposure to ionising…”
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Rapid implementation of SARS-CoV-2 sequencing to investigate cases of health-care associated COVID-19: a prospective genomic surveillance study by Meredith, Luke W, Hamilton, William L, Warne, Ben, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Curran, Martin D, Parmar, Surendra, Caller, Laura G, Caddy, Sarah L, Khokhar, Fahad A, Yakovleva, Anna, Hall, Grant, Feltwell, Theresa, Forrest, Sally, Sridhar, Sushmita, Weekes, Michael P, Baker, Stephen, Brown, Nicholas, Moore, Elinor, Popay, Ashley, Roddick, Iain, Reacher, Mark, Gouliouris, Theodore, Peacock, Sharon J, Dougan, Gordon, Török, M Estée, Goodfellow, Ian

“…The burden and influence of health-care associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is unknown. We aimed to examine the…”
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The Capsule Regulatory Network of Klebsiella pneumoniae Defined by density-TraDISort by Dorman, Matthew J, Feltwell, Theresa, Goulding, David A, Parkhill, Julian, Short, Francesca L

“…infections affect infants and the immunocompromised, and the recent emergence of hypervirulent and multidrug-resistant lineages is a critical health care…”
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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P

“…Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening…”
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Patterns of within-host genetic diversity in SARS-CoV-2 by Tonkin-Hill, Gerry, Martincorena, Inigo, Amato, Roberto, Lawson, Andrew R J, Gerstung, Moritz, Johnston, Ian, Jackson, David K, Park, Naomi, Lensing, Stefanie V, Quail, Michael A, Gonçalves, Sónia, Ariani, Cristina, Spencer Chapman, Michael, Hamilton, William L, Meredith, Luke W, Hall, Grant, Jahun, Aminu S, Chaudhry, Yasmin, Hosmillo, Myra, Pinckert, Malte L, Georgana, Iliana, Yakovleva, Anna, Caller, Laura G, Caddy, Sarah L, Feltwell, Theresa, Khokhar, Fahad A, Houldcroft, Charlotte J, Curran, Martin D, Parmar, Surendra, Alderton, Alex, Nelson, Rachel, Harrison, Ewan M, Sillitoe, John, Bentley, Stephen D, Barrett, Jeffrey C, Torok, M Estee, Goodfellow, Ian G, Langford, Cordelia, Kwiatkowski, Dominic

“…Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The…”
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Patterns of genome evolution that have accompanied host adaptation in Salmonella by Langridge, Gemma C, Fookes, Maria, Connor, Thomas R, Feltwell, Theresa, Feasey, Nicholas, Parsons, Bryony N, Seth-Smith, Helena M B, Barquist, Lars, Stedman, Anna, Humphrey, Tom, Wigley, Paul, Peters, Sarah E, Maskell, Duncan J, Corander, Jukka, Chabalgoity, Jose A, Barrow, Paul, Parkhill, Julian, Dougan, Gordon, Thomson, Nicholas R

“…Significance Common features have been observed in the genome sequences of bacterial pathogens that infect few hosts. These “host adaptations” include the…”
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Parallel independent evolution of pathogenicity within the genus Yersinia by Reuter, Sandra, Connor, Thomas R., Barquist, Lars, Walker, Danielle, Feltwell, Theresa, Harris, Simon R., Fookes, Maria, Hall, Miquette E., Petty, Nicola K., Fuchs, Thilo M., Corander, Jukka, Dufour, Muriel, Ringwood, Tamara, Savin, Cyril, Bouchier, Christiane, Martin, Liliane, Miettinen, Minna, Shubin, Mikhail, Riehm, Julia M., Laukkanen-Ninios, Riikka, Sihvonen, Leila M., Siitonen, Anja, Skurnik, Mikael, Falcão, Juliana Pfrimer, Fukushima, Hiroshi, Scholz, Holger C., Prentice, Michael B., Wren, Brendan W., Parkhill, Julian, Carniel, Elisabeth, Achtman, Mark, McNally, Alan, Thomson, Nicholas R.

“…The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene…”
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Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections by Illingworth, Christopher Jr, Hamilton, William L, Warne, Ben, Routledge, Matthew, Popay, Ashley, Jackson, Chris, Fieldman, Tom, Meredith, Luke W, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Caller, Laura G, Caddy, Sarah L, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin D, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Ferris, Mark, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Goodfellow, Ian G, Gouliouris, Theodore, de Angelis, Daniela, Török, M Estée

“…SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of…”
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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome by Sharp, Sarah, Holden, Matthew TG, Holroyd, Simon, Churcher, Carol, Wang, Hongmei, Cerdeño-Tárraga, Ana M, Dowd, Linda, Parkhill, Julian, Baker, Stephen, Simmonds, Mark, Stevens, Kim, Dougan, Gordon, Quail, Michael A, Brooks, Karen, Thomson, Nicholas R, Hance, Zahra, Jagels, Kay, Roberts, Adam P, Davis, Paul, Sebaihia, Mohammed, Bason, Nathalie, Barrell, Bart, Fairweather, Neil F, Unwin, Louise, Feltwell, Theresa, Price, Claire, Chillingworth, Tracey, Mungall, Karen, Cronin, Ann, Whithead, Sally, Rabbinowitsch, Ester, Dupuy, Bruno, Wright, Anne, Mullany, Peter, Stabler, Richard, Fraser, Audrey, Wren, Brendan W, Minton, Nigel, Moule, Sharon

“…We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large…”
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A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events by Illingworth, Christopher J R, Hamilton, William L, Jackson, Christopher, Warne, Ben, Popay, Ashley, Meredith, Luke, Hosmillo, Myra, Jahun, Aminu, Fieldman, Tom, Routledge, Matthew, Houldcroft, Charlotte J, Caller, Laura, Caddy, Sarah, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Gouliouris, Theodore, Goodfellow, Ian, Angelis, Daniela De, Török, M Estée

“…Abstract Identifying linked cases of infection is a critical component of the public health response to viral infectious diseases. In a clinical context, there…”
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Separating Bacteria by Capsule Amount Using a Discontinuous Density Gradient by Feltwell, Theresa, Dorman, Matthew J, Goulding, David A, Parkhill, Julian, Short, Francesca L

“…Capsule is a key virulence factor in many bacterial species, mediating immune evasion and resistance to various physical stresses. While many methods are…”
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