Search Results - "FELDSTEIN, Ariel E"

Liquid biopsy for liver diseases by Mann, Jelena, Reeves, Helen L, Feldstein, Ariel E

“…With the growing number of novel therapeutic approaches for liver diseases, significant research efforts have been devoted to the development of liquid biopsy…”
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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis by Gaul, Susanne, Leszczynska, Aleksandra, Alegre, Fernando, Kaufmann, Benedikt, Johnson, Casey D., Adams, Leon A., Wree, Alexander, Damm, Georg, Seehofer, Daniel, Calvente, Carolina J., Povero, Davide, Kisseleva, Tatiana, Eguchi, Akiko, McGeough, Matthew D., Hoffman, Hal M., Pelegrin, Pablo, Laufs, Ulrich, Feldstein, Ariel E.

“…Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular…”
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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice by Wree, Alexander, Eguchi, Akiko, McGeough, Matthew D., Pena, Carla A., Johnson, Casey D., Canbay, Ali, Hoffman, Hal M., Feldstein, Ariel E.

“…Inflammasome activation plays a central role in the development of drug‐induced and obesity‐associated liver disease. However, the sources and mechanisms of…”
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Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223 by Calvente, Carolina Jimenez, Tameda, Masahiko, Johnson, Casey D, Del Pilar, Hana, Lin, Yun Chin, Adronikou, Nektaria, De Mollerat Du Jeu, Xavier, Llorente, Cristina, Boyer, Josh, Feldstein, Ariel E

“…Persistent, unresolved inflammation in the liver represents a key trigger for hepatic injury and fibrosis in various liver diseases and is controlled by…”
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Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH by Daemen, Sabine, Gainullina, Anastasiia, Kalugotla, Gowri, He, Li, Chan, Mandy M., Beals, Joseph W., Liss, Kim H., Klein, Samuel, Feldstein, Ariel E., Finck, Brian N., Artyomov, Maxim N., Schilling, Joel D.

“…Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat,…”
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NLRP3 inflammasome activation is required for fibrosis development in NAFLD by Wree, Alexander, McGeough, Matthew D., Peña, Carla A., Schlattjan, Martin, Li, Hongying, Inzaugarat, Maria Eugenia, Messer, Karen, Canbay, Ali, Hoffman, Hal M., Feldstein, Ariel E.

“…NLR inflammasomes, caspase 1 activation platforms critical for processing key pro-inflammatory cytokines, have been implicated in the development of…”
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Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease by Povero, Davide, Eguchi, Akiko, Li, Hongying, Johnson, Casey D, Papouchado, Bettina G, Wree, Alexander, Messer, Karen, Feldstein, Ariel E

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in both adult and children. Currently there are no reliable methods to…”
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NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL‐17 and TNF in mice by Wree, Alexander, McGeough, Matthew D., Inzaugarat, Maria Eugenia, Eguchi, Akiko, Schuster, Susanne, Johnson, Casey D., Peña, Carla A., Geisler, Lukas J., Papouchado, Bettina G., Hoffman, Hal M., Feldstein, Ariel E.

“…The NLRP3 inflammasome, a caspase‐1 activation platform, plays a key role in the modulation of liver inflammation and fibrosis. Here, we tested the hypothesis…”
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TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies by McGeough, Matthew D, Wree, Alexander, Inzaugarat, Maria E, Haimovich, Ariela, Johnson, Casey D, Peña, Carla A, Goldbach-Mansky, Raphaela, Broderick, Lori, Feldstein, Ariel E, Hoffman, Hal M

“…The NLRP3 inflammasome is a protein complex responsible for caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function…”
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Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress by Eguchi, Akiko, Lazic, Milos, Armando, Aaron M., Phillips, Susan A., Katebian, Roia, Maraka, Spyridoula, Quehenberger, Oswald, Sears, Dorothy D., Feldstein, Ariel E.

“…We recently reported that stressed adipocytes release extracellular vesicles (EVs) that act as “find-me” signals to promote macrophage migration and…”
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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease by Wang, Zeneng, Klipfell, Elizabeth, Bennett, Brian J., Koeth, Robert, Levison, Bruce S., DuGar, Brandon, Feldstein, Ariel E., Britt, Earl B., Fu, Xiaoming, Chung, Yoon-Mi, Wu, Yuping, Schauer, Phil, Smith, Jonathan D., Allayee, Hooman, Tang, W. H. Wilson, DiDonato, Joseph A., Lusis, Aldons J., Hazen, Stanley L.

“…Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death…”
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Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis by Dixon, Laura J, Flask, Chris A, Papouchado, Bettina G, Feldstein, Ariel E, Nagy, Laura E

“…Nonalcoholic steatohepatitis (NASH) is associated with caspase activation. However, a role for pro-inflammatory caspases or inflammasomes has not been explored…”
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Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis by Wree, Alexander, Holtmann, Theresa Maria, Inzaugarat, Maria Eugenia, Feldstein, Ariel E

“…Hepatocyte demise as well as signals released by stressed hepatocytes have been now recognized as important triggers of liver inflammation. While traditional…”
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The role of oxidized lipid species in insulin resistance and NASH in children by Santoro, Nicola, Feldstein, Ariel E

“…During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising…”
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NLR Family Pyrin Domain‐Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice by Inzaugarat, Maria Eugenia, Johnson, Casey D., Holtmann, Theresa Maria, McGeough, Matthew D., Trautwein, Christian, Papouchado, Bettina G., Schwabe, Robert, Hoffman, Hal M., Wree, Alexander, Feldstein, Ariel E.

“…The NLR family pyrin domain‐containing 3 (NLRP3) inflammasome plays an important role in liver fibrosis (LF) development. However, the mechanisms involved in…”
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Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis by Koh, Eun Hee, Yoon, Ji Eun, Ko, Myoung Seok, Leem, Jaechan, Yun, Ji-Young, Hong, Chung Hwan, Cho, Yun Kyung, Lee, Seung Eun, Jang, Jung Eun, Baek, Ji Yeon, Yoo, Hyun Ju, Kim, Su Jung, Sung, Chang Ohk, Lim, Joon Seo, Jeong, Won-Il, Back, Sung Hoon, Baek, In-Jeoung, Torres, Sandra, Solsona-Vilarrasa, Estel, Conde de la Rosa, Laura, Garcia-Ruiz, Carmen, Feldstein, Ariel E, Fernandez-Checa, Jose C, Lee, Ki-Up

“…Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined. Sphingolipids…”
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Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future by Wieckowska, Anna, McCullough, Arthur J., Feldstein, Ariel E.

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States, and its prevalence is increasing worldwide. It…”
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Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice by Schuster, Susanne, Johnson, Casey D., Hennebelle, Marie, Holtmann, Theresa, Taha, Ameer Y., Kirpich, Irina A., Eguchi, Akiko, Ramsden, Christopher E., Papouchado, Bettina G., McClain, Craig J., Feldstein, Ariel E.

“…Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with…”
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Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications by Alkhouri, Naim, Carter-Kent, Christine, Feldstein, Ariel E

“…Pathological increases in cell death in the liver as well as in peripheral tissues has emerged as an important mechanism involved in the development and…”
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Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis by Cannito, Stefania, Morello, Elisabetta, Bocca, Claudia, Foglia, Beatrice, Benetti, Elisa, Novo, Erica, Chiazza, Fausto, Rogazzo, Mara, Fantozzi, Roberto, Povero, Davide, Sutti, Salvatore, Bugianesi, Elisabetta, Feldstein, Ariel E, Albano, Emanuele, Collino, Massimo, Parola, Maurizio

“…Non-Alcoholic Fatty Liver Disease (NAFLD) is a major form of chronic liver disease in the general population in relation to its high prevalence among…”
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