Search Results - "FELDMAN, H. H"

The "rights" of precision drug development for Alzheimer's disease by Cummings, Jeffrey, Feldman, Howard H, Scheltens, Philip

“…There is a high rate of failure in Alzheimer's disease (AD) drug development with 99% of trials showing no drug-placebo difference. This low rate of success…”
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Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group by Dubois, Bruno, Villain, Nicolas, Frisoni, Giovanni B, Rabinovici, Gil D, Sabbagh, Marwan, Cappa, Stefano, Bejanin, Alexandre, Bombois, Stéphanie, Epelbaum, Stéphane, Teichmann, Marc, Habert, Marie-Odile, Nordberg, Agneta, Blennow, Kaj, Galasko, Douglas, Stern, Yaakov, Rowe, Christopher C, Salloway, Stephen, Schneider, Lon S, Cummings, Jeffrey L, Feldman, Howard H

“…In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a purely biological definition of Alzheimer's disease that relies on…”
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Negativity begets longevity in T cells by Feldman, H Alex, Cevik, Hilal, Waggoner, Stephen N

“…Killer immunoglobulin-like receptors (KIRs) are polymorphic receptors for human leukocyte antigens (HLAs) that provide positive or negative signals controlling…”
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Exome sequencing as first‐tier test for fetuses with severe central nervous system structural anomalies by Yaron, Y., Ofen Glassner, V., Mory, A., Zunz Henig, N., Kurolap, A., Bar Shira, A., Brabbing Goldstein, D., Marom, D., Ben Sira, L., Baris Feldman, H., Malinger, G., Krajden Haratz, K., Reches, A.

“…ABSTRACT Objective Prenatally detected central nervous system (CNS) anomalies present a diagnostic challenge. In this study, we compared the diagnostic yield…”
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Clinical trials and late‐stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 by Schneider, L. S., Mangialasche, F., Andreasen, N., Feldman, H., Giacobini, E., Jones, R., Mantua, V., Mecocci, P., Pani, L., Winblad, B., Kivipelto, M.

“…The modern era of drug development for Alzheimer's disease began with the proposal of the cholinergic hypothesis of memory impairment and the 1984 research…”
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Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p by HSIUNG, Ging-Yuek R, DEJESUS-HERNANDEZ, Mariely, BAKER, Matt, RADEMAKERS, Rosa, MACKENZIE, Ian R. A, FELDMAN, Howard H, SENGDY, Pheth, BOUCHARD-KERR, Phoenix, DWOSH, Emily, BUTLER, Rachel, LEUNG, Bonnie, FOK, Alice, RUTHERFORD, Nicola J

“…Frontotemporal dementia and amyotrophic lateral sclerosis are closely related clinical syndromes with overlapping molecular pathogenesis. Several families have…”
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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Hampel, Harald, Prof, Molinuevo, José Luis, MD, Blennow, Kaj, MD, DeKosky, Steven T, Prof, Gauthier, Serge, Prof, Selkoe, Dennis, Prof, Bateman, Randall, MD, Cappa, Stefano, MD, Crutch, Sebastian, PhD, Engelborghs, Sebastiaan, MD, Frisoni, Giovanni B, Prof, Fox, Nick C, MD, Galasko, Douglas, Prof, Habert, Marie-Odile, MD, Jicha, Gregory A, MD, Nordberg, Agneta, MD, Pasquier, Florence, Prof, Rabinovici, Gil, MD, Robert, Philippe, Prof, Rowe, Christopher, MD, Salloway, Stephen, Prof, Sarazin, Marie, Prof, Epelbaum, Stéphane, MD, de Souza, Leonardo C, MD, Vellas, Bruno, Prof, Visser, Pieter J, MD, Schneider, Lon, Prof, Stern, Yaakov, Prof, Scheltens, Philip, Prof, Cummings, Jeffrey L, Prof

“…Summary In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging–Alzheimer's Association have contributed…”
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Reducing Readmissions among Heart Failure Patients Discharged to Home Health Care: Effectiveness of Early and Intensive Nursing Services and Early Physician Follow‐Up by Murtaugh, Christopher M., Deb, Partha, Zhu, Carolyn, Peng, Timothy R., Barrón, Yolanda, Shah, Shivani, Moore, Stanley M., Bowles, Kathryn H., Kalman, Jill, Feldman, Penny H., Siu, Albert L.

“…Objective To compare the effectiveness of two “treatments”—early, intensive home health nursing and physician follow‐up within a week—versus less intense and…”
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Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe by FELDMAN, H. H, DOODY, R. S, BREAZNA, A, KIVIPELTO, M, SPARKS, D. L, WATERS, D. D, JONES, R. W, SCHWAM, E, SCHINDLER, R, HEY-HADAVI, J, DEMICCO, D. A

“…There is some evidence that statins may have a protective and symptomatic benefit in Alzheimer disease (AD). The LEADe study is a randomized controlled trial…”
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Revising the definition of Alzheimer's disease: a new lexicon by Dubois, Bruno, Prof, Feldman, Howard H, Prof, Jacova, Claudia, PhD, Cummings, Jeffrey L, MD, DeKosky, Steven T, Prof, Barberger-Gateau, Pascale, MD, Delacourte, André, PhD, Frisoni, Giovanni, Prof, Fox, Nick C, Prof, Galasko, Douglas, Prof, Gauthier, Serge, Prof, Hampel, Harald, Prof, Jicha, Gregory A, MD, Meguro, Kenichi, MD, O'Brien, John, DM, Pasquier, Florence, Prof, Robert, Philippe, Prof, Rossor, Martin, Prof, Salloway, Steven, Prof, Sarazin, Marie, MD, de Souza, Leonardo C, MD, Stern, Yaakov, Prof, Visser, Pieter J, MD, Scheltens, Philip, Prof

“…Summary Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent advances in use of reliable biomarkers of AD that…”
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The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene by Mackenzie, Ian R. A., Baker, Matt, Pickering-Brown, Stuart, Hsiung, Ging-Yuek R., Lindholm, Caroline, Dwosh, Emily, Gass, Jennifer, Cannon, Ashley, Rademakers, Rosa, Hutton, Mike, Feldman, Howard H.

“…The most common pathology in frontotemporal dementia (FTD) is tau-negative, ubiquitin-immunoreactive (ub-ir) neuronal inclusions (FTLD-U). Recently, we…”
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Iterated Learning Models of Language Change: A Case Study of Sino‐Korean Accent by Ito, Chiyuki, Feldman, Naomi H.

“…Iterated learning models of language evolution have typically been used to study the emergence of language, rather than historical language change. We use…”
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Targeting natural killer cells to enhance vaccine responses by Cox, Andrew, Cevik, Hilal, Feldman, H. Alex, Canaday, Laura M., Lakes, Nora, Waggoner, Stephen N.

“…Vaccination serves as a cornerstone of global health. Successful prevention of infection or disease by vaccines is achieved through elicitation of…”
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Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin by Hu, Fenghua, Padukkavidana, Thihan, Vægter, Christian B., Brady, Owen A., Zheng, Yanqiu, Mackenzie, Ian R., Feldman, Howard H., Nykjaer, Anders, Strittmatter, Stephen M.

“…The most common inherited form of Frontotemporal Lobar Degeneration (FTLD) known stems from Progranulin ( GRN) mutation and exhibits TDP-43 plus ubiquitin…”
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Ubiquitin Immunohistochemistry Suggests Classic Motor Neuron Disease, Motor Neuron Disease With Dementia, and Frontotemporal Dementia of the Motor Neuron Disease Type Represent a Clinicopathologic Spectrum by Mackenzie, Ian R. A, H. Feldman, Howard

“…ABSTRACTOne of the characteristic pathologic changes in classic motor neuron disease (MND) is the presence of ubiquitin-immunoreactive (ub-ir) inclusions in…”
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The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease by Albert, Marilyn S, DeKosky, Steven T, Dickson, Dennis, Dubois, Bruno, Feldman, Howard H, Fox, Nick C, Gamst, Anthony, Holtzman, David M, Jagust, William J, Petersen, Ronald C, Snyder, Peter J, Carrillo, Maria C, Thies, Bill, Phelps, Creighton H

“…Abstract The National Institute on Aging and the Alzheimer’s Association charged a workgroup with the task of developing criteria for the symptomatic…”
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Assessing Systemic Lupus Erythematosus Care: Myopic Evaluations and the Elephant in the Room by Bermas, Bonnie L., Feldman, Candace H.

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A Role for the Developing Lexicon in Phonetic Category Acquisition by Feldman, Naomi H., Griffiths, Thomas L., Goldwater, Sharon, Morgan, James L.

“…Infants segment words from fluent speech during the same period when they are learning phonetic categories, yet accounts of phonetic category acquisition…”
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Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy by Olazarán, Javier, Reisberg, Barry, Clare, Linda, Cruz, Isabel, Peña-Casanova, Jordi, Del Ser, Teodoro, Woods, Bob, Beck, Cornelia, Auer, Stefanie, Lai, Claudia, Spector, Aimee, Fazio, Sam, Bond, John, Kivipelto, Miia, Brodaty, Henry, Rojo, José Manuel, Collins, Helen, Teri, Linda, Mittelman, Mary, Orrell, Martin, Feldman, Howard H, Muñiz, Ruben

“…Nonpharmacological therapies (NPTs) can improve the quality of life (QoL) of people with Alzheimer's disease (AD) and their carers. The objective of this study…”
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Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria by Dubois, Bruno, Hampel, Harald, Feldman, Howard H, Scheltens, Philip, Aisen, Paul, Andrieu, Sandrine, Bakardjian, Hovagim, Benali, Habib, Bertram, Lars, Blennow, Kaj, Broich, Karl, Cavedo, Enrica, Crutch, Sebastian, Dartigues, Jean-François, Duyckaerts, Charles, Epelbaum, Stéphane, Frisoni, Giovanni B, Gauthier, Serge, Genthon, Remy, Gouw, Alida A, Habert, Marie-Odile, Holtzman, David M, Kivipelto, Miia, Lista, Simone, Molinuevo, José-Luis, O'Bryant, Sid E, Rabinovici, Gil D, Rowe, Christopher, Salloway, Stephen, Schneider, Lon S, Sperling, Reisa, Teichmann, Marc, Carrillo, Maria C, Cummings, Jeffrey, Jack, Cliff R

“…Abstract During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to…”
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