Search Results - "FEITSMA, Harma"

Zebrafish as a Cancer Model by Feitsma, Harma, Cuppen, Edwin

“…The zebrafish has developed into an important model organism for biomedical research over the last decades. Although the main focus of zebrafish research has…”
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Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b by Wansleeben, Carolien, Feitsma, Harma, Montcouquiol, Mireille, Kroon, Carla, Cuppen, Edwin, Meijlink, Frits

“…Among the cellular properties that are essential for the organization of tissues during animal development, the importance of cell polarity in the plane of…”
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Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries by Mokry, Michal, Feitsma, Harma, Nijman, Isaac J, de Bruijn, Ewart, van der Zaag, Pieter J, Guryev, Victor, Cuppen, Edwin

“…Microarray-based enrichment of selected genomic loci is a powerful method for genome complexity reduction for next-generation sequencing. Since the vast…”
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Targeted locus amplification to develop robust patient-specific assays for liquid biopsies in pediatric solid tumors by van Zogchel, Lieke M J, Lak, Nathalie S M, Gelineau, Nina U, Sergeeva, Irina, Stelloo, Ellen, Swennenhuis, Joost, Feitsma, Harma, van Min, Max, Splinter, Erik, Bleijs, Margit, Groot Koerkamp, Marian, Breunis, Willemijn, Meister, Michael Torsten, Kholossy, Waleed Hassan, Holstege, Frank C P, Molenaar, Jan J, de Leng, Wendy W J, Stutterheim, Janine, van der Schoot, C Ellen, Tytgat, Godelieve A M

“…Liquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy…”
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An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions by Wansleeben, Carolien, van Gurp, Léon, Feitsma, Harma, Kroon, Carla, Rieter, Ester, Verberne, Marlies, Guryev, Victor, Cuppen, Edwin, Meijlink, Frits

“…Mutagenesis screens in the mouse have been proven useful for the identification of novel gene functions and generation of interesting mutant alleles. Here we…”
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Mlh1 Deficiency in Zebrafish Results in Male Sterility and Aneuploid as Well as Triploid Progeny in Females by Feitsma, Harma, Leal, Marcelo C, Moens, Peter B, Cuppen, Edwin, Schulz, Rudiger W

“…In most eukaryotes, recombination of homologous chromosomes during meiosis is necessary for proper chromosome pairing and subsequent segregation. The molecular…”
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Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1 by Leal, Marcelo C., Feitsma, Harma, Cuppen, Edwin, França, Luiz R., Schulz, Rüdiger W.

“…Mlh1 is a member of DNA mismatch repair (MMR) machinery and is also essential for the stabilization of crossovers during the first meiotic division. Recently,…”
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Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential by Zhang, Chunye, Stelloo, Ellen, Barrans, Sharon, Cucco, Francesco, Jiang, Dan, Tzioni, Maria-Myrsini, Chen, Zi, Li, Yan, Swennenhuis, Joost F., Makker, Jasmine, Rásó-Barnett, Lívia, Liu, Hongxiang, El-Daly, Hesham, Soilleux, Elizabeth, Shah, Nimish, Nagumantry, Sateesh Kumar, Kyaw, Maw, Prahladan, Mahesh Panatt, Tooze, Reuben, Westhead, David R., Feitsma, Harma, Davies, Andrew J., Burton, Catherine, Johnson, Peter W. M., Du, Ming-Qing

“…MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or…”
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Proximity ligation‐based sequencing for the identification of human papillomavirus genomic integration sites in formalin‐fixed paraffin embedded oropharyngeal squamous cell carcinomas by Demers, Imke, Balaji, Harini, Feitsma, Harma, Stelloo, Ellen, Swennenhuis, Joost, Sergeeva, Irina, Wuerdemann, Nora, Hout, Mari F. C. M., Wagner, Steffen, Kremer, Bernd, Klussmann, Jens P., Huebbers, Christian U., Speel, Ernst‐Jan M.

“…Human papillomavirus (HPV) infections are an increasing cause of oropharyngeal squamous cell carcinomas (OPSCC). Integration of the viral genome into the host…”
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High Prevalence of Chromosomal Rearrangements and LINE Retrotranspositions Detected in Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Tissue by Rubio-Alarcón, Carmen, Stelloo, Ellen, Vessies, Daan C.L., van 't Erve, Iris, Mekkes, Nienke J., Swennenhuis, Joost, Lakbir, Soufyan, van Bree, Elisabeth J., Tijssen, Marianne, Delis-van Diemen, Pien, Lanfermeijer, Mirthe, Linders, Theodora, van den Broek, Daan, Punt, Cornelis J.A., Heringa, Jaap, Meijer, Gerrit A., Abeln, Sanne, Feitsma, Harma, Fijneman, Remond J.A.

“…Structural variants (SVs) caused by chromosomal rearrangements in common fragile sites or long interspersed nuclear element (LINE) retrotranspositions are…”
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Formalin-Fixed, Paraffin-Embedded–Targeted Locus Capture by Stelloo, Ellen, Meijers, Ruud W.J., Swennenhuis, Joost F., Allahyar, Amin, Hajo, Karima, Cangiano, Mario, de Leng, Wendy W.J., van Helvert, Sjoerd, Van der Meulen, Joni, Creytens, David, van Kempen, Léon C., Cleton-Jansen, Anne-Marie, Bovee, Judith V.M.G., de Laat, Wouter, Splinter, Erik, Feitsma, Harma

“…Chromosomal rearrangements are important drivers in cancer, and their robust detection is essential for diagnosis, prognosis, and treatment selection,…”
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Comparison of NTRK fusion detection methods in microsatellite-instability-high metastatic colorectal cancer by Schraa, Suzanna J., Stelloo, Ellen, Laclé, Miangela M., Swennenhuis, Joost F., Brosens, Lodewijk A. A., Fijneman, Remond J. A., Feitsma, Harma, Koopman, Miriam, de Leng, Wendy W., Vink, Geraldine R., Bol, Guus M.

“…Tropomyosin receptor kinase (TRK) inhibitors have been approved for metastatic solid tumors harboring NTRK fusions, but the detection of NTRK fusions is…”
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Minimal residual disease (MRD) detection in acute lymphoblastic leukaemia based on fusion genes and genomic deletions: towards MRD for all by Kuiper, Roland P., Hoogeveen, Patricia G., Bladergroen, Reno, Dijk, Freerk, Sonneveld, Edwin, Leeuwen, Frank N., Boer, Judith, Sergeeva, Irina, Feitsma, Harma, Boer, Monique L., Velden, Vincent H. J.

“…Summary Minimal residual disease (MRD) diagnostics are implemented in most clinical protocols for patients with acute lymphoblastic leukaemia (ALL) and are…”
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Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing by Allahyar, Amin, Pieterse, Mark, Swennenhuis, Joost, Los-de Vries, G. Tjitske, Yilmaz, Mehmet, Leguit, Roos, Meijers, Ruud W. J., van der Geize, Robert, Vermaat, Joost, Cleven, Arjen, van Wezel, Tom, Diepstra, Arjan, van Kempen, Léon C., Hijmering, Nathalie J., Stathi, Phylicia, Sharma, Milan, Melquiond, Adrien S. J., de Vree, Paula J. P., Verstegen, Marjon J. A. M., Krijger, Peter H. L., Hajo, Karima, Simonis, Marieke, Rakszewska, Agata, van Min, Max, de Jong, Daphne, Ylstra, Bauke, Feitsma, Harma, Splinter, Erik, de Laat, Wouter

“…In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding (FFPE) procedures for examination of (intra-) cellular…”
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Formalin-Fixed, Paraffin-Embedded-Targeted Locus Capture: A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors by Stelloo, Ellen, Meijers, Ruud W J, Swennenhuis, Joost F, Allahyar, Amin, Hajo, Karima, Cangiano, Mario, de Leng, Wendy W J, van Helvert, Sjoerd, Van der Meulen, Joni, Creytens, David, van Kempen, Léon C, Cleton-Jansen, Anne-Marie, Bovee, Judith V M G, de Laat, Wouter, Splinter, Erik, Feitsma, Harma

“…Chromosomal rearrangements are important drivers in cancer, and their robust detection is essential for diagnosis, prognosis, and treatment selection,…”
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Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development by BLASCHKE, Rudiger J, HAHURIJ, Nathan D, SCHÖLER, Hans, FEITSMA, Harma, ROTTBAUER, Wolfgang, BLUM, Martin, MEIJLINK, Frits, RAPPOLD, Gudrun, GITTENBERGER-DE GROOT, Adriana C, KUIJPER, Sanne, JUST, Steffen, WISSE, Lambertus J, DEISSLER, Kirsten, MAXELON, Tina, ANASTASSIADIS, Konstantinos, SPITZER, Jessica, HARDT, Stefan E

“…Identifying molecular pathways regulating the development of pacemaking and coordinated heartbeat is crucial for a comprehensive mechanistic understanding of…”
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Highly Efficient ENU Mutagenesis in Zebrafish by de Bruijn, Ewart, Cuppen, Edwin, Feitsma, Harma

“…ENU (N-ethyl-N-nitrosourea) mutagenesis is a widely accepted and proven method to introduce random point mutations in the genome. Because there are no targeted…”
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Abstract 401: The impact of DNA structural variants on PRKN gene function and colorectal cancer pathogenesis by van Bree, Elisabeth J., Lakbir, Soufyan, Rubio-Alarcón, Carmen, de Wit, Renske, Bolijn, Anne, Delis-van Diemen, Pien, Tijssen, Marianne, Stelloo, Ellen, Feitsma, Harma, Meijer, Gerrit A., Carvalho, Beatriz, Abeln, Sanne, Fijneman, Remond J.

“…Abstract Background: Cancer is caused by somatic DNA alterations, such as single nucleotide variants, somatic copy number alterations and structural variants…”
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Abstract 2229: Targeted locus amplification based sequencing for mapping viral integration sites in human papillomavirus positive head and neck squamous cell carcinomas by Demers, Imke, Balaji, Harini, Feitsma, Harma, Sergeeva, Irinia, Swennenhuis, Joost, Wuerdemann, Nora, Wagner, Steffen, Kremer, Bernd, Huebbers, Christian, Klussmann, Jens Peter, Speel, Ernst-Jan

“…Abstract Background: Human papillomavirus (HPV) infections are the principal cause of cervical cancers, subsets of anogenital and head and neck cancers (HNC)…”
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Zebrafish with Mutations in Mismatch Repair Genes Develop Neurofibromas and Other Tumors by FEITSMA, Harma, KUIPER, Raoul V, KORVING, Jeroen, NIJMAN, Isaac J, CUPPEN, Edwin

“…Defective mismatch repair (MMR) in humans causes hereditary nonpolyposis colorectal cancer. This genetic predisposition to colon cancer is linked to…”
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