Search Results - "FEINSTEIN, S. C"

Human Microtubule-Associated-Protein Tau Regulates the Number of Protofilaments in Microtubules: A Synchrotron X-Ray Scattering Study by Choi, M.C., Raviv, U., Miller, H.P., Gaylord, M.R., Kiris, E., Ventimiglia, D., Needleman, D.J., Kim, M.W., Wilson, L., Feinstein, S.C., Safinya, C.R.

“…Microtubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nanotubes with walls comprised of assembled protofilaments built from…”
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Identification of a Novel Microtubule Binding and Assembly Domain in the Developmentally Regulated Inter-Repeat Region of Tau by Goode, Bruce L., Feinstein, Stuart C.

“…Tau is a developmentally regulated microtubule-associated protein that influences microtubule behavior by directly associating with tubulin. The carboxyl…”
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Distribution of intracerebral ventricularly administered neurotrophins in rat brain and its correlation with trk receptor expression by Yan, Q, Matheson, C, Sun, J, Radeke, M J, Feinstein, S C, Miller, J A

“…To assess the potential effectiveness by which injected neurotrophins can diffuse throughout the brain, we used autoradiographic and immunohistochemical…”
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Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy by Genualdi, C., Feinstein, S.C., Wilson, L., Jordan, M.A., Stagg, N.J.

“…The microtubule inhibitor (MTI) class of chemotherapeutics provide an effective treatment for several different types of cancers, however, severe…”
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Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly by Goode, B L, Denis, P E, Panda, D, Radeke, M J, Miller, H P, Wilson, L, Feinstein, S C

“…Tau is a neuronal microtubule-associated protein that promotes microtubule assembly, stability, and bundling in axons. Two distinct regions of tau are…”
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Presence or absence of TrkA protein distinguishes subsets of small sensory neurons with unique cytochemical characteristics and dorsal horn projections by Molliver, D C, Radeke, M J, Feinstein, S C, Snider, W D

“…Investigations into the biological actions of nerve growth factor (NGF) have shown that dorsal root ganglion (DRG) neurons subserving nociception require NGF…”
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Fibers of tau fragments, but not full length tau, exhibit a cross β-structure: Implications for the formation of paired helical filaments by GIANNETTI, A.M., LINDWALL, G., CHAU, M.-F., RADEKE, M.J., FEINSTEIN, S.C., KOHLSTAEDT, L.A.

“…We have used X-ray fiber diffraction to probe the structure of fibers of tau and tau fragments. Fibers of fragments from the microtubule binding domain had a…”
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Sense and antisense transfection analysis of tau function : tau influences net microtubule assembly, neurite outgrowth and neuritic stability by ESMAELI-AZAD, B, MCCARTY, J. H, FEINSTEIN, S. C

“…Microtubules are fundamental elements participating in many aspects of cell behavior and maintenance, yet the factors regulating microtubule behavior in vivo…”
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Nerve Growth Factor-Induced Neurite Outgrowth in PC12 Cells Involves the Coordinate Induction of Microtubule Assembly and Assembly-Promoting Factors by Drubin, David G., Feinstein, Stuart C., Shooter, Eric M., Kirschner, Marc W.

“…Nerve growth factor (NGF) regulates the microtubule-dependent extension and maintenance of axons by some peripheral neurons. We show here that one effect of…”
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Imaging real-time neurite outgrowth and cytoskeletal reorganization with an atomic force microscope by Lal, R, Drake, B, Blumberg, D, Saner, D R, Hansma, P K, Feinstein, S C

“…An atomic force microscope was used to image the morphology and structural reorganization of rat NIH/3T3 fibroblasts and PC-12 cells growing in petri dishes…”
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Compartmental expression of trkB receptor protein in the developing striatum by Costantini, L.C., Feinstein, S.C., Radeke, M.J., Snyder-Keller, A.

“…To investigate the role of neurotrophins in the initial formation of striatal patch versus matrix, the spatial and temporal expression of trkB receptors was…”
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Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system by Washiyama, K, Muragaki, Y, Rorke, LB, Lee, VM, Feinstein, SC, Radeke, MJ, Blumberg, D, Kaplan, DR, Trojanowski, JQ

“…Primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS) are poorly understood childhood neoplasms, and medulloblastomas are the most…”
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Differential Regulation of Microtubule Dynamics by Three- and Four-Repeat Tau: Implications for the Onset of Neurodegenerative Disease by Panda, Dulal, Samuel, Jonathan C., Massie, Michelle, Feinstein, Stuart C., Wilson, Leslie

“…The microtubule (MT)-associated protein tau is important in neuronal development and in Alzheimer's and other neurodegenerative diseases. Genetic analyses have…”
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Structural and Functional Differences between 3-Repeat and 4-Repeat Tau Isoforms: implications for normal Tau function and the onset of neurodegenerative disease by Goode, B L, Chau, M, Denis, P E, Feinstein, S C

“…Tau, MAP2, and MAP4 are members of a microtubule-associated protein (MAP) family that are each expressed as "3-repeat" and "4-repeat" isoforms. These isoforms…”
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Evidence for Two Distinct Binding Sites for Tau on Microtubules by Makrides, Victoria, Massie, Michelle R., Feinstein, Stuart C., Lew, John, Carbon, John A.

“…The microtubule-associated protein tau regulates diverse and essential microtubule functions, from the nucleation and promotion of microtubule polymerization…”
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Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction by MCCARTY, J. H, FEINSTEIN, S. C

“…The TrkB receptor tyrosine kinase (RTK) is a high affinity receptor for the neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-4/5…”
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Nerve Growth Factor Rapidly Induces Ornithine Decarboxylase mRNA in PC12 Rat Pheochromocytoma Cells by Feinstein, Stuart C., Dana, Sharon L., McConlogue, Lisa, Shooter, Eric M., Coffino, Philip

“…The mechanism by which nerve growth factor (NGF) stimulates ornithine decarboxylase (OrnDCase; EC 4.1.1.17) activity in the rat pheochromocytoma cell line PC12…”
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Immunocytochemical localization of TrkB in the central nervous system of the adult rat by Yan, Qiao, Radeke, Monte J., Matheson, Christine R., Talvenheimo, Jane, Welcher, Andrew A., Felnstein, Stuart C.

“…The TrkB family of transmembrane proteins serve as receptors for brain‐derived neurotrophic factor (BDNF), neurotrophin (NT)‐4/5, and possibly NT‐3, three…”
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Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies by Makrides, Victoria, Shen, Ting E, Bhatia, Rajinder, Smith, Bettye L, Thimm, Julian, Lal, Ratneshwar, Feinstein, Stuart C

“…The accumulation of abnormal tau filaments is a pathological hallmark of many neurodegenerative diseases. In 1998, genetic analyses revealed a direct linkage…”
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"Speedprep" purification of template for double-stranded DNA sequencing by Goode, B L, Feinstein, S C

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