Search Results - "FEIL, Susanne"

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis by Feil, Susanne, Fehrenbacher, Birgit, Lukowski, Robert, Essmann, Frank, Schulze-Osthoff, Klaus, Schaller, Martin, Feil, Robert

“…RATIONALE:Atherosclerosis is a widespread and devastating disease, but the origins of cells within atherosclerotic plaques are not well defined. OBJECTIVE:To…”
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Pore-forming protein toxins: from structure to function by Parker, Michael W., Feil, Susanne C.

“…Pore-forming protein toxins (PFTs) are one of Nature's most potent biological weapons. An essential feature of their toxicity is the remarkable property that…”
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Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes by Rutkowski, Nelli, Görlitz, Frederik, Wiesner, Eva, Binz-Lotter, Julia, Feil, Susanne, Feil, Robert, Benzing, Thomas, Hackl, Matthias J.

“…Recent clinical trials of drugs enhancing cyclic guanosine monophosphate (cGMP) signaling for cardiovascular diseases have renewed interest in cGMP biology…”
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Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins by Lawrence, Sara L., Gorman, Michael A., Feil, Susanne C., Mulhern, Terrence D., Kuiper, Michael J., Ratner, Adam J., Tweten, Rodney K., Morton, Craig J., Parker, Michael W.

“…Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. Cholesterol serves as…”
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Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells by Ghoreschi, Kamran, Brück, Jürgen, Kellerer, Christina, Deng, Caishu, Peng, Haiyan, Rothfuss, Oliver, Hussain, Rehana Z, Gocke, Anne R, Respa, Annedore, Glocova, Ivana, Valtcheva, Nadejda, Alexander, Eva, Feil, Susanne, Feil, Robert, Schulze-Osthoff, Klaus, Rupec, Rudolf A, Lovett-Racke, Amy E, Dringen, Ralf, Racke, Michael K, Röcken, Martin

“…Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation…”
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cGMP Signaling and Vascular Smooth Muscle Cell Plasticity by Lehners, Moritz, Dobrowinski, Hyazinth, Feil, Susanne, Feil, Robert

“…Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of…”
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Structural Studies of Streptococcus pyogenes Streptolysin O Provide Insights into the Early Steps of Membrane Penetration by Feil, Susanne C., Ascher, David B., Kuiper, Michael J., Tweten, Rodney K., Parker, Michael W.

“…Cholesterol-dependent cytolysins (CDCs) are a large family of bacterial toxins that exhibit a dependence on the presence of membrane cholesterol in forming…”
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A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis by Wen, Lai, Feil, Susanne, Wolters, Markus, Thunemann, Martin, Regler, Frank, Schmidt, Kjestine, Friebe, Andreas, Olbrich, Marcus, Langer, Harald, Gawaz, Meinrad, de Wit, Cor, Feil, Robert

“…Mechanisms that limit thrombosis are poorly defined. One of the few known endogenous platelet inhibitors is nitric oxide (NO). NO activates NO sensitive…”
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Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation by Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.

“…Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection…”
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Structure of the Lectin Regulatory Domain of the Cholesterol-Dependent Cytolysin Lectinolysin Reveals the Basis for Its Lewis Antigen Specificity by Feil, Susanne C., Lawrence, Sara, Mulhern, Terrence D., Holien, Jessica K., Hotze, Eileen M., Farrand, Stephen, Tweten, Rodney K., Parker, Michael W.

“…The cholesterol-dependent cytolysins (CDCs) punch holes in target cell membranes through a highly regulated process. Streptococcus mitis lectinolysin (LLY)…”
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Role of the NO-GC/cGMP signaling pathway in platelet biomechanics by Balmes, Aylin, Rodríguez, Johanna G, Seifert, Jan, Pinto-Quintero, Daniel, Khawaja, Akif A, Boffito, Marta, Frye, Maike, Friebe, Andreas, Emerson, Michael, Seta, Francesca, Feil, Robert, Feil, Susanne, Schäffer, Tilman E

“…Cyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been…”
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Transgenic Mice for cGMP Imaging by Thunemann, Martin, Wen, Lai, Hillenbrand, Matthias, Vachaviolos, Angelos, Feil, Susanne, Ott, Thomas, Han, Xiaoxing, Fukumura, Dai, Jain, Rakesh K, Russwurm, Michael, de Wit, Cor, Feil, Robert

“…RATIONALE:Cyclic GMP (cGMP) is an important intracellular signaling molecule in the cardiovascular system, but its spatiotemporal dynamics in vivo is largely…”
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Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography by Thunemann, Martin, Schörg, Barbara F., Feil, Susanne, Lin, Yun, Voelkl, Jakob, Golla, Matthias, Vachaviolos, Angelos, Kohlhofer, Ursula, Quintanilla-Martinez, Leticia, Olbrich, Marcus, Ehrlichmann, Walter, Reischl, Gerald, Griessinger, Christoph M., Langer, Harald F., Gawaz, Meinrad, Lang, Florian, Schäfers, Michael, Kneilling, Manfred, Pichler, Bernd J., Feil, Robert

“…Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their…”
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Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth by Dhayade, Sandeep, Kaesler, Susanne, Sinnberg, Tobias, Dobrowinski, Hyazinth, Peters, Stefanie, Naumann, Ulrike, Liu, He, Hunger, Robert E., Thunemann, Martin, Biedermann, Tilo, Schittek, Birgit, Simon, Hans-Uwe, Feil, Susanne, Feil, Robert

“…Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of…”
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The Hyperpolarization-Activated Channel HCN4 Is Required for the Generation of Pacemaker Action Potentials in the Embryonic Heart by Stieber, Juliane, Herrmann, Stefan, Feil, Susanne, Löster, Jana, Feil, Robert, Biel, Martin, Hofmann, Franz, Ludwig, Andreas

“…Hyperpolarization-activated, cyclic nucleotide-gated cation currents, termed Ifor Ih, are generated by four members of the hyperpolarization-activated, cyclic…”
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Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes by Zhang, Yujing, Benz, Pascal, Stehle, Daniel, Yang, Shang, Kurz, Hendrikje, Feil, Susanne, Nagel, Georg, Feil, Robert, Gao, Shiqiang, Bender, Markus

“…Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet…”
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HCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart by Fenske, Stefanie, Mader, Robert, Scharr, Andreas, Paparizos, Christos, Cao-Ehlker, Xiaochun, Michalakis, Stylianos, Shaltiel, Lior, Weidinger, Martha, Stieber, Juliane, Feil, Susanne, Feil, Robert, Hofmann, Franz, Wahl-Schott, Christian, Biel, Martin

“…RATIONALE:The hyperpolarization-activated current Ih that is generated by hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) plays a key role…”
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Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity by Luo, Ceng, Gangadharan, Vijayan, Bali, Kiran Kumar, Xie, Rou-Gang, Agarwal, Nitin, Kurejova, Martina, Tappe-Theodor, Anke, Tegeder, Irmgard, Feil, Susanne, Lewin, Gary, Polgar, Erika, Todd, Andrew J, Schlossmann, Jens, Hofmann, Franz, Liu, Da-Lu, Hu, San-Jue, Feil, Robert, Kuner, Thomas, Kuner, Rohini

“…Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve…”
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Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase by Polekhina, Galina, Gupta, Abhilasha, van Denderen, Bryce J.W., Feil, Susanne C., Kemp, Bruce E., Stapleton, David, Parker, Michael W.

“…AMP-activated protein kinase (AMPK) coordinates cellular metabolism in response to energy demand as well as to a variety of stimuli. The AMPK β subunit acts as…”
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Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health by Gorman, Michael A., Seers, Christine A., Michell, Belinda J., Feil, Susanne C., Huq, N. Laila, Cross, Keith J., Reynolds, Eric C., Parker, Michael W.

“…The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of…”
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