Search Results - "FEELISCH, M"

Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans by Erzurum, S.C, Ghosh, S, Janocha, A.J, Xu, W, Bauer, S, Bryan, N.S, Tejero, J, Hemann, C, Hille, R, Stuehr, D.J, Feelisch, M, Beall, C.M

“…The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as…”
Get full text

A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome by Sutton, T.R., Minnion, M., Barbarino, F., Koster, G., Fernandez, B.O., Cumpstey, A.F., Wischmann, P., Madhani, M., Frenneaux, M.P., Postle, A.D., Cortese-Krott, M.M., Feelisch, M.

“…Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, and numerous analytical methods exist for the…”
Get full text

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation by BAILEY, J. C, FEELISCH, M, HOROWITZ, J. D, FRENNEAUX, M. P, MADHANI, M

“…Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under…”
Get full text

The use of nitric oxide donors in pharmacological studies by Feelisch, M

“…A growing appreciation of the involvement of nitric oxide (NO) in numerous bioregulatory pathways has not only opened up new therapeutic avenues for organic…”
Get full text

The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations by Ridnour, Lisa A, Thomas, Douglas D, Mancardi, Daniele, Espey, Michael G, Miranda, Katrina M, Paolocci, Nazareno, Feelisch, Martin, Fukuto, Jon, Wink, David A

“…This review addresses many of the chemical aspects of nitrosative stress mediated by N2O3. From a cellular perspective, N2O3 and the resulting reactive…”
Get more information

Measurement of in vivo nitric oxide synthesis in humans using stable isotopic methods: a systematic review by Siervo, M., Stephan, B.C.M., Feelisch, M., Bluck, L.J.C.

“…Stable isotopic methods are considered the “gold standard” for the measurement of rates of in vivo NO production. However, values reported for healthy human…”
Get full text

Is sunlight good for our heart? by Feelisch, Martin, Kolb-Bachofen, Victoria, Liu, Donald, Lundberg, Jon O., Revelo, Lucia P., Suschek, Christoph V., Weller, Richard B.

Get full text

Nitroxyl Anion Exerts Redox-Sensitive Positive Cardiac Inotropy in vivo by Calcitonin Gene-Related Peptide Signaling by Paolocci, Nazareno, Saavedra, Walter F., Miranda, Katrina M., Martignani, Cristian, Isoda, Takayoshi, Hare, Joshua M., Espey, Michael G., Fukuto, Jon M., Feelisch, Martin, Wink, David A., Kass, David A.

“…Nitroxyl anion (NO-)is the one-electron reduction product of nitric oxide (NO·) and is enzymatically generated by NO synthase in vitro. The physiologic…”
Get full text

Biotransformation to nitric oxide of organic nitrates in comparison to other nitrovasodilators by Feelisch, M

“…Nitrovasodilators are prodrugs which, although chemically heterogenous, exert their pharmacodynamic action via a common pathway, i.e. the release of nitric…”
Get more information

0099. Nitrite reductase activity during sepsis by Simon, V, Dyson, A, Minnion, M, Feelisch, M, Singer, M

Get full text

Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine by Pino, R Z, Feelisch, M

“…Nitroxyl (NO-) is the one-electron reduction product of nitric oxide (NO.). Recently, NO- generating compounds were shown to possess potent vasorelaxant…”
Get more information

Oxidative release of nitric oxide accounts for guanylyl cyclase stimulating, vasodilator and anti-platelet activity of Piloty's acid: a comparison with Angeli's salt by Zamora, R, Grzesiok, A, Weber, H, Feelisch, M

“…The decomposition of benzenesulphohydroxamic acid (Piloty's acid; PA) and some of its derivatives has been reported to yield nitroxyl ions (NO-), a species…”
Get full text

Paradoxical Fate and Biological Action of Peroxynitrite on Human Platelets by Moro, Maria Angeles, Darley-Usmar, Victor M., Goodwin, David A., Read, Nicholas G., Zamora-Pino, Ruben, Feelisch, Martin, Radomski, Marek W., Moncada, Salvador

“…Peroxynitrite (ONOO-), which is formed from the reaction of nitric oxide (NO) and superoxide (O- 2), has been suggested to be responsible for some of the…”
Get full text

Regulation of the L‐type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase‐mediated inhibition by JI, G. J., FLEISCHMANN, B. K., BLOCH, W., FEELISCH, M., ANDRESSEN, C., ADDICKS, K., HESCHELER, J.

“…ABSTRACT In adult mammalian cardiomyocytes, stimulation of muscarinic receptors counterbalances the β‐adrenoceptor‐mediated increase in myocardial…”
Get full text

Identification of N‐iminoethyl‐l‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells by McCall, T.B., Feelisch, M., Palmer, R.M.J., Moncada, S.

“…1 The synthesis of nitric oxide (NO) from l‐arginine by rat peritoneal neutrophils (PMN) and the murine macrophage cell‐line J774 and the inhibition of this…”
Get full text

Superoxide dismutase and catalase are required to detect NO from both coupled and uncoupled neuronal no synthase by Reif, A., Shutenko, Z.V., Feelisch, M., Schmidt, H.H.H.W.

“…Despite numerous approaches to measuring nitric oxide ( NO) formation from purified NO synthase (NOS), it is still not clear whether NO is a direct or indirect…”
Get full text

Inhibition of endothelial cell activation by nitric oxide donors by Zampolli, A, Basta, G, Lazzerini, G, Feelisch, M, De Caterina, R

“…Because nitric oxide (NO) inhibits the expression of endothelial leukocyte adhesion molecules, NO-generating compounds have major therapeutic potential for use…”
Get more information

Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure by Leo, Francesca, Suvorava, Tatsiana, Heuser, Sophia K., Li, Junjie, LoBue, Anthea, Barbarino, Frederik, Piragine, Eugenia, Schneckmann, Rebekka, Hutzler, Beate, Good, Miranda E., Fernandez, Bernadette O., Vornholz, Lukas, Rogers, Stephen, Doctor, Allan, Grandoch, Maria, Stegbauer, Johannes, Weitzberg, Eddie, Feelisch, Martin, Lundberg, Jon O., Isakson, Brant E., Kelm, Malte, Cortese-Krott, Miriam M.

“…Current paradigms suggest that nitric oxide (NO) produced by endothelial cells (ECs) through endothelial nitric oxide synthase (eNOS) in the vessel wall is the…”
Get full text

Nitric oxide modulates sympathetic neurotransmission at the prejunctional level by Addicks, K, Bloch, W, Feelisch, M

“…In spite of accumulating evidence for a modulation of sympathetic neurotransmission by endogenously produced nitric oxide (NO), it remains unclear in which…”
Get more information

Molecular mechanisms of nitrovasodilator bioactivation by Noack, E, Feelisch, M

“…All nitrovasodilators act intracellularly by a common molecular mechanism. This is characterized by the release of nitric oxide (NO). They are, thus, prodrugs…”
Get full text