Search Results - "FEDOROV, Alexey Yu"

Liposomal Formulation of a PLA2-Sensitive Phospholipid-Allocolchicinoid Conjugate: Stability and Activity Studies In Vitro by Kobanenko, Maria K, Tretiakova, Daria S, Shchegravina, Ekaterina S, Antipova, Nadezhda V, Boldyrev, Ivan A, Fedorov, Alexey Yu, Vodovozova, Elena L, Onishchenko, Natalia R

“…To assess the stability and efficiency of liposomes carrying a phospholipase A2-sensitive phospholipid-allocolchicinoid conjugate (aC-PC) in the bilayer, egg…”
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Synthesis, Molecular Docking, In Vitro and In Vivo Studies of Novel Dimorpholinoquinazoline-Based Potential Inhibitors of PI3K/Akt/mTOR Pathway by Zapevalova, Maria V., Shchegravina, Ekaterina S., Fonareva, Irina P., Salnikova, Diana I., Sorokin, Danila V., Scherbakov, Alexander M., Maleev, Alexander A., Ignatov, Stanislav K., Grishin, Ivan D., Kuimov, Alexander N., Konovalova, Maryia V., Svirshchevskaya, Elena V., Fedorov, Alexey Yu

“…A (series) range of potential dimorpholinoquinazoline-based inhibitors of the PI3K/Akt/mTOR cascade was synthesized. Several compounds exhibited cytotoxicity…”
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Enhancing Precision in Photodynamic Therapy: Innovations in Light-Driven and Bioorthogonal Activation by Kuzmina, Natalia S, Fedotova, Ekaterina A, Jankovic, Petar, Gribova, Galina P, Nyuchev, Alexander V, Fedorov, Alexey Yu, Otvagin, Vasilii F

“…Over the past few decades, photodynamic therapy (PDT) has evolved as a minimally invasive treatment modality offering precise control over cancer and various…”
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Design, Synthesis and In Vitro Investigation of Cabozantinib-Based PROTACs to Target c-Met Kinase by Sachkova, Anastasia A, Andreeva, Daria V, Tikhomirov, Alexander S, Scherbakov, Alexander M, Salnikova, Diana I, Sorokin, Danila V, Bogdanov, Fedor B, Rysina, Yulia D, Shchekotikhin, Andrey E, Shchegravina, Ekaterina S, Fedorov, Alexey Yu

“…(1) Background: This investigation aimed at developing a series of c-Met-targeting cabozantinib-based PROTACs. (2) Methods: Purification of intermediate and…”
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Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids by Gracheva, Iuliia A, Svirshchevskaya, Elena V, Shchegravina, Ekaterina S, Malysheva, Yulia B, Sitdikova, Alsu R, Fedorov, Alexey Yu

“…A series of novel heterocyclic colchicine derivatives bearing a C-7 methylene fragment were synthesized via Wittig, Horner-Wadsworth-Emmons and…”
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Thermally Induced Surface Structure and Morphology Evolution in Bimetallic Pt-Au/HOPG Nanoparticles as Probed Using XPS and STM by Fedorov, Alexey Yu, Bukhtiyarov, Andrey V, Panafidin, Maxim A, Prosvirin, Igor P, Zubavichus, Yan V, Bukhtiyarov, Valerii I

“…Bimetallic nanoparticles expand the possibilities of catalyst design, providing an extra degree of freedom for tailoring the catalyst structure in comparison…”
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Near-Ambient Pressure XPS and MS Study of CO Oxidation over Model Pd-Au/HOPG Catalysts: The Effect of the Metal Ratio by Bukhtiyarov, Andrey V, Prosvirin, Igor P, Panafidin, Maxim A, Fedorov, Alexey Yu, Klyushin, Alexander Yu, Knop-Gericke, Axel, Zubavichus, Yan V, Bukhtiyarov, Valery I

“…In this study, the dependence of the catalytic activity of highly oriented pyrolytic graphite (HOPG)-supported bimetallic Pd-Au catalysts towards the CO…”
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Water-Soluble Chlorin/Arylaminoquinazoline Conjugate for Photodynamic and Targeted Therapy by Otvagin, Vasilii F, Kuzmina, Natalia S, Krylova, Lubov V, Volovetsky, Arthur B, Nyuchev, Alexander V, Gavryushin, Andrei E, Meshkov, Ivan N, Gorbunova, Yulia G, Romanenko, Yuliya V, Koifman, Oscar I, Balalaeva, Irina V, Fedorov, Alexey Yu

“…A new water-soluble conjugate, consisting of a chlorin-e 6 photosensitizer part, a 4-arylaminoquinazoline moiety with affinity to epidermal growth factor…”
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Design and Synthesis of New Protease‐Triggered CO‐Releasing Peptide–Metal‐Complex Conjugates by Sitnikov, Nikolay S., Malysheva, Yulia B., Fedorov, Alexey Yu, Schmalz, Hans‐Günther

“…Aiming at the development of novel protease‐triggered CO‐releasing molecules (PT‐CORMs) we designed a series of oxycyclohexadiene‐Fe(CO)3 complexes, which are…”
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Synthesis and Biological Evaluation of Furanoallocolchicinoids by Voitovich, Yuliya V, Shegravina, Ekaterina S, Sitnikov, Nikolay S, Faerman, Vladimir I, Fokin, Valery V, Schmalz, Hans-Gunther, Combes, Sebastien, Allegro, Diane, Barbier, Pascal, Beletskaya, Irina P, Svirshchevskaya, Elena V, Fedorov, Alexey Yu

“…A series of conformationally flexible furan-derived allocolchicinoids was prepared from commercially available colchicine in good to excellent yields using a…”
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Organolead-Mediated Arylations: 2-(3,3-Diphenylallyloxy)phenyllead Triacetate as an Internal Free-Radical-Trap-Containing Reagent by Fedorov, Alexey Yu. , Finet, Jean-Pierre

“…2‐(3,3‐Diphenylprop‐2‐enyloxy)phenyllead triacetate, an arylating reagent containing an internal free radical trap, was synthesised and its behaviour studied…”
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Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin by Sazanova, Ekaterina S, Gracheva, Iuliia A, Allegro, Diane, Barbier, Pascale, Combes, Sébastien, Svirshchevskaya, Elena V, Fedorov, Alexey Yu

“…We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously…”
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Completing the picture of tolazamide polymorphism under extreme conditions: a low‐temperature study by Fedorov, Alexey Yu, Rychkov, Denis A., Losev, Evgeniy A., Drebushchak, Tatiana N., Boldyreva, Elena V.

“…We present the results of an experimental and computational study of structural changes in two polymorphs of tolazamide {systematic name:…”
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A novel crystal form of metacetamol: the first example of a hydrated form by Zemtsova, Viktoria M., Fedorov, Alexey Yu, Fedorova, Elizaveta A., Boa, Callum, Arkhipov, Sergey G., Rychkov, Denis A., Minkov, Vasily S., Pulham, Colin R., Boldyreva, Elena V.

“…We report the crystal structure and crystallization conditions of a first hydrated form of metacetamol (a hemihydrate), C8H9NO2·0.5H2O. It crystallizes from…”
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Synthesis of Indole-Derived Allocolchicine Congeners through Pd-Catalyzed Intramolecular C-H Arylation Reaction by Sitnikov, Nikolay S., Kokisheva, Antonina S., Fukin, Georgy K., Neudörfl, Jörg-Martin, Sutorius, Hannah, Prokop, Aram, Fokin, Valery V., Schmalz, Hans-Günther, Fedorov, Alexey Yu

“…The synthesis of several new heterocyclic structural analogs of the natural antimitotic agent allocolchicine is reported. As a key step an intramolecular…”
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B‑nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner by Stein, Andreas, Hilken née Thomopoulou, Persefoni, Frias, Corazon, Hopff, Sina M, Varela, Paloma, Wilke, Nicola, Mariappan, Arul, Neudörfl, Jörg-Martin, Fedorov, Alexey Yu, Gopalakrishnan, Jay, Gigant, Benoît, Prokop, Aram, Schmalz, Hans-Günther

“…Colchicine, the main active alkaloid from Colchicum autumnale L., is a potent tubulin binder and represents an interesting lead structure for the development…”
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A Convenient Entry to New C-7-Modified Colchicinoids through Azide Alkyne [3+2] Cycloaddition: Application of Ring-Contractive Rearrangements by Schmalz, Hans-Günther, Nicolaus, Norman, Reball, Jens, Sitnikov, Nikolay, Yu. Fedorov, Alexey, Velder, Janna, Termath, Andreas

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Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives by Gracheva, Iuliia A, Shchegravina, Ekaterina S, Schmalz, Hans-Günther, Beletskaya, Irina P, Fedorov, Alexey Yu

“…Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use…”
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Conjugates of Porphyrinoid-Based Photosensitizers with Cytotoxic Drugs: Current Progress and Future Directions toward Selective Photodynamic Therapy by Otvagin, Vasilii F, Kuzmina, Natalia S, Kudriashova, Ekaterina S, Nyuchev, Alexander V, Gavryushin, Andrei E, Fedorov, Alexey Yu

“…Photodynamic therapy (PDT) is a treatment modality where light-mediated activation of photosensitizers in a patient’s body leads to the generation of cytotoxic…”
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Seeking the best model for non-covalent interactions within the crystal structure of meloxicam by Fedorov, Alexey Yu, Drebushchak, Tatiana N., Tantardini, Christian

“…[Display omitted] •RDG, DFT and Hirshfeld surface methods helped to find the best model of NCIs.•The study was performed for the fully optimized structure of…”
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