Search Results - "FEBS letters"

Mitochondrial DNA copy number in human disease: the more the better? by Filograna, Roberta, Mennuni, Mara, Alsina, David, Larsson, Nils‐Göran

“…Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained…”
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Role of mitochondrial ROS in the brain: from physiology to neurodegeneration by Angelova, Plamena R., Abramov, Andrey Y.

“…Mitochondria are key cell organelles in that they are responsible for energy production and control many processes from signalling to cell death. The function…”
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Structural and functional diversity calls for a new classification of ABC transporters by Thomas, Christoph, Aller, Stephen G., Beis, Konstantinos, Carpenter, Elisabeth P., Chang, Geoffrey, Chen, Lei, Dassa, Elie, Dean, Michael, Duong Van Hoa, Franck, Ekiert, Damian, Ford, Robert, Gaudet, Rachelle, Gong, Xin, Holland, I. Barry, Huang, Yihua, Kahne, Daniel K., Kato, Hiroaki, Koronakis, Vassilis, Koth, Christopher M., Lee, Youngsook, Lewinson, Oded, Lill, Roland, Martinoia, Enrico, Murakami, Satoshi, Pinkett, Heather W., Poolman, Bert, Rosenbaum, Daniel, Sarkadi, Balazs, Schmitt, Lutz, Schneider, Erwin, Shi, Yigong, Shyng, Show‐Ling, Slotboom, Dirk J., Tajkhorshid, Emad, Tieleman, D. Peter, Ueda, Kazumitsu, Váradi, András, Wen, Po‐Chao, Yan, Nieng, Zhang, Peng, Zheng, Hongjin, Zimmer, Jochen, Tampé, Robert

“…Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous…”
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Mitochondrial dynamics in health and disease by Yapa, Nethmi M.B., Lisnyak, Valerie, Reljic, Boris, Ryan, Michael T.

“…In animals, mitochondria are mainly organised into an interconnected tubular network extending across the cell along a cytoskeletal scaffold. Mitochondrial…”
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Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations by Luan, Binquan, Wang, Haoran, Huynh, Tien

“…Recently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants (B.1.1.7 and B.1351) have emerged harbouring mutations that make them highly…”
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Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease by Nissanka, Nadee, Moraes, Carlos T.

“…Mitochondria are essential organelles within the cell where most ATP is produced through oxidative phosphorylation (OXPHOS). A subset of the genes needed for…”
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The promise and the challenges of cryo‐electron tomography by Turk, Martin, Baumeister, Wolfgang

“…Structural biologists have traditionally approached cellular complexity in a reductionist manner in which the cellular molecular components are fractionated…”
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Mitochondrial dysfunction and cell senescence: deciphering a complex relationship by Chapman, James, Fielder, Edward, Passos, João F.

“…Cellular senescence and mitochondrial dysfunction have both been defined as classical hallmarks of the ageing process. Here, we review the intricate…”
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The role of mitochondrial ROS in the aging brain by Stefanatos, Rhoda, Sanz, Alberto

“…The brain is the most complex human organ, consuming more energy than any other tissue in proportion to its size. It relies heavily on mitochondria to produce…”
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Noncoding RNAs in disease by Lekka, Evangelia, Hall, Jonathan

“…Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has…”
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Meta-analyses of human gut microbes associated with obesity and IBD by Walters, William A., Xu, Zech, Knight, Rob

“…Recent studies have linked human gut microbes to obesity and inflammatory bowel disease, but consistent signals have been difficult to identify. Here we test…”
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Mitochondrial disorders of the OXPHOS system by Fernandez‐Vizarra, Erika, Zeviani, Massimo

“…Mitochondrial disorders are among the most frequent inborn errors of metabolism, their primary cause being the dysfunction of the oxidative phosphorylation…”
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A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins by Kikhney, Alexey G., Svergun, Dmitri I.

“…Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and structural transitions of biological macromolecules in solution…”
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Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration by Nakamura, Yoshihiro, Miyaki, Shigeru, Ishitobi, Hiroyuki, Matsuyama, Sho, Nakasa, Tomoyuki, Kamei, Naosuke, Akimoto, Takayuki, Higashi, Yukihito, Ochi, Mitsuo

“…•Mesenchymal stem cell exosomes promoted myogenesis and angiogenesis in vitro.•Mesenchymal stem cell exosomes accelerated muscle regeneration in a mouse injury…”
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Ergothioneine – a diet‐derived antioxidant with therapeutic potential by Halliwell, Barry, Cheah, Irwin K., Tang, Richard M. Y.

“…Ergothioneine is a thiol/thione molecule synthesised only by some fungi and bacteria. Nonetheless, it is avidly taken up from the diet by humans and other…”
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Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology by Fukuto, Jon M., Ignarro, Louis J., Nagy, Peter, Wink, David A., Kevil, Christopher G., Feelisch, Martin, Cortese‐Krott, Miriam M., Bianco, Christopher L., Kumagai, Yoshito, Hobbs, Adrian J., Lin, Joseph, Ida, Tomoaki, Akaike, Takaaki

“…The chemical biology of thiols (RSH, e.g., cysteine and cysteine‐containing proteins/peptides) has been a topic of extreme interest for many decades due to…”
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The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms by Kang, Inhae, Chu, Charleen T., Kaufman, Brett A.

“…The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mtDNA)‐binding protein essential for genome maintenance. TFAM functions in…”
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Cell‐penetrating peptides: 20 years later, where do we stand? by Bechara, Chérine, Sagan, Sandrine

“…Twenty years ago, the discovery of peptides able to cross cellular membranes launched a novel field in molecular delivery based on these non‐invasive vectors,…”
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Mitochondria, energy, and metabolism in neuronal health and disease by Trigo, Diogo, Avelar, Catarina, Fernandes, Miguel, Sá, Juliana, Cruz e Silva, Odete

“…Mitochondria are associated with various cellular activities critical to homeostasis, particularly in the nervous system. The plastic architecture of the…”
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mTORC1 and mTORC2 as regulators of cell metabolism in immunity by Linke, Monika, Fritsch, Stephanie Deborah, Sukhbaatar, Nyamdelger, Hengstschläger, Markus, Weichhart, Thomas

“…The mechanistic target of rapamycin (mTOR) pathway is an evolutionarily conserved signaling pathway that senses intra‐ and extracellular nutrients, growth…”
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