Search Results - "FEBBRAIO, M. A"

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding by Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., White, P. J., Kraegen, E. W., Marette, A., Cooney, G. J., Febbraio, M. A., Bruce, C. R.

“…Aims/hypothesis While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin…”
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Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase by Matthews, V. B, Åström, M.-B, Chan, M. H. S, Bruce, C. R, Krabbe, K. S, Prelovsek, O, Åkerström, T, Yfanti, C, Broholm, C, Mortensen, O. H, Penkowa, M, Hojman, P, Zankari, A, Watt, M. J, Bruunsgaard, H, Pedersen, B. K, Febbraio, M. A

“…Aims/hypothesis Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the…”
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Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance by Matthews, V. B, Allen, T. L, Risis, S, Chan, M. H. S, Henstridge, D. C, Watson, N, Zaffino, L. A, Babb, J. R, Boon, J, Meikle, P. J, Jowett, J. B, Watt, M. J, Jansson, J.-O, Bruce, C. R, Febbraio, M. A

“…Aims/hypothesis The role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to…”
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Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease by Watt, K. I., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F., Gregorevic, P.

“…Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal…”
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Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro by Petersen, E W, Carey, A L, Sacchetti, M, Steinberg, G R, Macaulay, S L, Febbraio, M A, Pedersen, B K

“…To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes and/or whether it exerts this effect independently of changes…”
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PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications by Lancaster, G. I., Kammoun, H. L., Kraakman, M. J., Kowalski, G. M., Bruce, C. R., Febbraio, M. A.

“…Protein kinase R (PKR) has previously been suggested to mediate many of the deleterious consequences of a high-fat diet (HFD). However, previous studies have…”
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Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice by Henstridge, D. C., Bruce, C. R., Pang, C. P., Lancaster, G. I., Allen, T. L., Estevez, E., Gardner, T., Weir, J. M., Meikle, P. J., Lam, K. S. L., Xu, A., Fujii, N., Goodyear, L. J., Febbraio, M. A.

“…Aims/hypothesis Although skeletal muscle insulin resistance has been associated with activation of c-Jun N-terminal kinase (JNK), whether increased JNK…”
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2009 Stock Conference Report: Inflammation, Obesity and Metabolic Disease by Hevener, A.L, Febbraio, M.A

“…Obesity is linked with many deleterious health consequences and is associated with increased risk of chronic disease including type 2 diabetes, atherosclerosis…”
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Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro by PINNAMANENI, S. K, SOUTHGATE, R. J, FEBBRAIO, M. A, WATT, M. J

“…Stearoyl CoA desaturase 1 (SCD1) is implicated in mediating obesity and insulin resistance. Paradoxically, SCD1 converts saturated fatty acids, the lipid…”
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Examination of ‘lipotoxicity’ in skeletal muscle of high‐fat fed and ob/ob mice by Turpin, S. M., Ryall, J. G., Southgate, R., Darby, I., Hevener, A. L., Febbraio, M. A., Kemp, B. E., Lynch, G. S., Watt, M. J.

“…Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to the pathogenesis of the metabolic syndrome and heart disease…”
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HSP72 gene expression progressively increases in human skeletal muscle during prolonged, exhaustive exercise by Febbraio, M. A, Koukoulas, I

“…1  Exercise Physiology and Metabolism Laboratory, Department of Physiology, and 2  Howard Florey Institute of Experimental Physiology and Medicine, The…”
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Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice by Kowalski, G. M, Nicholls, H. T, Risis, S, Watson, N. K, Kanellakis, P, Bruce, C. R, Bobik, A, Lancaster, G. I, Febbraio, M. A

“…Aims/hypothesis Recent work has identified the important roles of M1 pro-inflammatory and M2 anti-inflammatory macrophages in the regulation of insulin…”
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Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle by Campbell, S E, Febbraio, M A

“…To examine the roles of 17beta-estradiol (E(2)) and progesterone (Prog) in lipid metabolism, skeletal muscle enzyme activities were studied in female…”
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Targeting gp130 to prevent inflammation and promote insulin action by Kraakman, M. J., Allen, T. L., Whitham, M., Iliades, P., Kammoun, H. L., Estevez, E., Lancaster, G. I., Febbraio, M. A.

“…Obesity and type 2 diabetes are now the most prevalent metabolic diseases in the Western world and the development of new strategies to treat these metabolic…”
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Effect of the ovarian hormones on GLUT4 expression and contraction-stimulated glucose uptake by Campbell, S E, Febbraio, M A

“…This study examined the roles of the female sex steroids, 17beta-estradiol (E(2)) and progesterone (Prog), on glucose uptake and GLUT4 protein expression…”
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Interleukin-6 and tumor necrosis factor-α are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness by CAREY, A. L, BRUCE, C. R, SACCHETTI, M, ANDERSON, M. J, OLSEN, D. B, SALTIN, B, HAWLEY, J. A, FEBBRAIO, M. A

“…Our aim was to examine the possible direct relationship of interleukin-6 and TNFalpha with insulin sensitivity in humans. We carried out two series of…”
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Effect of ambient temperature on human skeletal muscle metabolism during fatiguing submaximal exercise by Parkin, J. M, Carey, M. F, Zhao, S, Febbraio, M. A

“…Exercise Metabolism Unit, School of Life Sciences and Technology, Victoria University of Technology, Footscray 3001; and Exercise Physiology and Metabolism…”
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Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, during exercise in humans by Starkie, R. L., Arkinstall, M. J., Koukoulas, I., Hawley, J. A., Febbraio, M. A.

“…The present study was undertaken to examine the effects of exercise and carbohydrate (CHO) ingestion on interleukin-6 (IL-6) gene expression in skeletal muscle…”
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Hepatic lactate uptake versus leg lactate output during exercise in humans by Nielsen, H. B, Febbraio, M. A, Ott, P, Krustrup, P, Secher, N. H

“…Copenhagen Muscle Research Center, Departments of 1 Anesthesiology and 2 Hepatology, Rigshospitalet, and 5 August Krogh Institute, University of Copenhagen, 4…”
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Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) α and δ and PPAR coactivator 1α in human skeletal muscle, but not lipid regulatory genes by Watt, M J, Southgate, R J, Holmes, A G, Febbraio, M A

“…Fatty acids are an important ligand for peroxisome proliferator-activated receptor (PPAR) activation and transcriptional regulation of metabolic genes. To…”
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