Treatment with Olanzapine is Associated with Modulation of the Default Mode Network in Patients with Schizophrenia

Earlier studies have shown widespread alterations of functional connectivity of various brain networks in schizophrenia, including the default mode network (DMN). The DMN has also an important role in the performance of cognitive tasks. Furthermore, treatment with second-generation antipsychotic dru...

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Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 35; no. 4; pp. 904 - 912
Main Authors:	SAMBATARO, Fabio, BLASI, Giuseppe, POPOLIZIO, Teresa, NARDINI, Marcello, BERTOLINO, Alessandro, FAZI, Leonardo, CAFORIO, Grazia, TAURISANO, Paolo, ROMANO, Raffaella, DI GIORGIO, Annabella, GELAO, Barbara, LO BIANCO, Luciana, PAPAZACHARIAS, Apostolos
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-03-2010
Subjects:	Adult Adult and adolescent clinical studies Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Benzodiazepines - pharmacology Benzodiazepines - therapeutic use Biological and medical sciences Brain - blood supply Brain - drug effects Brain Mapping Case-Control Studies Chi-Square Distribution Female Follow-Up Studies Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Medical sciences Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - pathology Memory, Short-Term - drug effects Nerve Net - blood supply Nerve Net - drug effects Neuropharmacology Neuropsychological Tests Olanzapine Original Oxygen - blood Pharmacology. Drug treatments Principal Component Analysis - methods Prospective Studies Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Schizophrenia Schizophrenia - complications Schizophrenia - drug therapy Schizophrenia - pathology Time Factors Young Adult Human Dibenzodiazepine derivatives Atypical antipsychotic Olanzapine Neuroleptic Psychotropic Dopamine antagonist Serotonin antagonist Pharmacotherapy Schizophrenia Serotonine receptor Ventromedial prefrontal cortex Nuclear magnetic resonance imaging Thienobenzodiazepine derivatives Psychosis fMRI D2 Dopamine receptor Treatment antipsychotics Working memory default mode network Functional imaging
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Summary:	Earlier studies have shown widespread alterations of functional connectivity of various brain networks in schizophrenia, including the default mode network (DMN). The DMN has also an important role in the performance of cognitive tasks. Furthermore, treatment with second-generation antipsychotic drugs may ameliorate to some degree working memory (WM) deficits and related brain activity. The aim of this study was to evaluate the effects of treatment with olanzapine monotherapy on functional connectivity among brain regions of the DMN during WM. Seventeen patients underwent an 8-week prospective study and completed two functional magnetic resonance imaging (fMRI) scans at 4 and 8 weeks of treatment during the performance of the N-back WM task. To control for potential repetition effects, 19 healthy controls also underwent two fMRI scans at a similar time interval. We used spatial group-independent component analysis (ICA) to analyze fMRI data. Relative to controls, patients with schizophrenia had reduced connectivity strength within the DMN in posterior cingulate, whereas it was greater in precuneus and inferior parietal lobule. Treatment with olanzapine was associated with increases in DMN connectivity with ventromedial prefrontal cortex, but not in posterior regions of DMN. These results suggest that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia. In addition, our findings suggest critical functional differences in the regions of DMN.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0893-133X 1740-634X
DOI:	10.1038/npp.2009.192