Search Results - "FATTORETTI, Patrizia"
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Cerebrospinal fluid biomarkers and cognitive status in differential diagnosis of frontotemporal dementia and Alzheimer’s disease
Published in Journal of international medical research (01-10-2019)“…Objective This study aimed to determine the most appropriate cognitive and cerebrospinal fluid (CSF) biomarker setting to distinguish frontotemporal dementia…”
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Adapted physical exercise enhances activation and differentiation potential of satellite cells in the skeletal muscle of old mice
Published in Journal of anatomy (01-05-2016)“…During ageing, a progressive loss of skeletal muscle mass and a decrease in muscle strength and endurance take place, in the condition termed sarcopenia. The…”
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Modulatory Effect of Aerobic Physical Activity on Synaptic Ultrastructure in the Old Mouse Hippocampus
Published in Frontiers in aging neuroscience (16-05-2018)“…Aerobic physical exercise (APE) leads to improved brain functions. To better understand the beneficial effect of APE on the aging brain, a morphometric study…”
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Platelets in Alzheimer's disease-associated cellular senescence and inflammation
Published in Current pharmaceutical design (01-03-2013)“…Alzheimer's disease (AD) is a complex degenerative disorder of the brain, associated with a progressive cognitive decline. Age is the main risk factor with…”
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Effects of ageing on the fine distribution of the circadian CLOCK protein in reticular formation neurons
Published in Histochemistry and cell biology (01-06-2007)“…Many biochemical, physiological and behavioural processes, from bacteria to human, exhibit roughly 24 h cyclic oscillations defined as circadian rhythms…”
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Chronic Aluminum Administration to Old Rats Results in Increased Levels of Brain Metal Ions and Enlarged Hippocampal Mossy Fibers
Published in Annals of the New York Academy of Sciences (01-06-2004)“…: The effect of chronic aluminium administration (2 g/L/6 months) was investigated in the central nervous system (CNS) of old rats. The content of Al3+, Cu2+,…”
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A Ketogenic Diet Increases Succinic Dehydrogenase Activity in Aging Cardiomyocytes
Published in Annals of the New York Academy of Sciences (01-08-2009)“…Impairment of energy metabolism and an increase of reactive oxygen species (ROS) production seem to play a major role in age‐related apoptotic loss of…”
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Long-term visual object recognition memory in aged rats
Published in Rejuvenation research (01-04-2008)“…Aging is associated with memory impairments, but the neural bases of this process need to be clarified. To this end, behavioral protocols for memory testing…”
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Neuronal Death versus Synaptic Pathology in Alzheimer's Disease
Published in Annals of the New York Academy of Sciences (01-12-2003)“…: Neuron and synapse numeric densities as well as the average size and surface density of the synaptic junctional areas were measured in the hippocampus and…”
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Increased Mitochondrial and Nuclear Gene Expression of Cytochrome Oxidase Subunits I and IV in Neuronal Aging
Published in Annals of the New York Academy of Sciences (01-12-2004)“…: To assess the role of mitochondrial metabolic competence (MMC) in neuronal aging, quantitative immunohistochemistry of cytochrome oxidase (COX) subunits I…”
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Distribution of MAP2 in Hippocampus and Cerebellum of Young and Old Rats by Quantitative Immunohistochemistry
Published in The journal of histochemistry and cytochemistry (01-08-2001)“…The microtubule-associated protein MAP2 is a cytoskeletal protein that plays a regulatory role in neuronal plasticity and in maintaining the morphology of…”
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Testosterone administration increases synaptic density in the gyrus dentatus of old mice independently of physical exercise
Published in Experimental gerontology (01-10-2019)“…Testosterone and physical exercise administration have been shown to affect hippocampal morphology in adult rodents. In aged animals, similar data are only…”
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The effect of chronic aluminum(III) administration on the nervous system of aged rats: clues to understand its suggested role in Alzheimer's disease
Published in Journal of Alzheimer's disease (01-12-2003)“…The effect of chronic aluminum intake has been investigated in the brain of aged male Wistar rats to assess the potential role of the accumulation of this…”
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Effect of a Comprehensive Intervention on Plasma BDNF in Patients with Alzheimer's Disease
Published in Journal of Alzheimer's disease (01-01-2017)“…A comprehensive intervention (CI) on patients with Alzheimer's disease was assessed by measuring plasmabrain-derived neurotrophic factor (pBDNF) and ADAS-Cog…”
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MRI characterization of rat brain aging at structural and functional level: Clues for translational applications
Published in Experimental gerontology (01-09-2021)“…Magnetic resonance imaging (MRI) paradigms, using non-invasive approaches, can provide relevant findings about brain aging. The attention has been primarily…”
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Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease
Published in Journal of Alzheimer's disease (01-01-2013)“…Increasing experimental evidence indicates that synaptic alterations play a key role in cognitive decline in Alzheimer's disease (AD). Functional and…”
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Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment
Published in Journal of Alzheimer's disease (22-02-2016)“…We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI_P)…”
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Neonatal exposure to permethrin pesticide causes lifelong fear and spatial learning deficits and alters hippocampal morphology of synapses
Published in Journal of neurodevelopmental disorders (29-03-2014)“…During the neurodevelopmental period, the brain is potentially more susceptible to environmental exposure to pollutants. The aim was to determine if neonatal…”
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Peripheral inflammatory biomarkers of Alzheimer’s disease: the role of platelets
Published in Biogerontology (Dordrecht) (01-10-2010)“…Alzheimer’s disease is an age-dependent neurodegenerative disorder characterized by loss of neurons, synaptic degeneration, senile plaques and neurofibrillary…”
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Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain
Published in Ageing research reviews (01-07-2010)“…Abstract Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a century, have recently shown beneficial effects also in…”
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