Search Results - "FATMI, Muhammad Qaiser"
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Exploring Natural Products from the Biodiversity of Pakistan for Computational Drug Discovery Studies: Collection, Optimization, Design and Development of A Chemical Database (ChemDP)
Published in Current computer-aided drug design (01-09-2015)“…Pakistan possesses a rich and vast source of natural products (NPs). Some of these secondary metabolites have been identified as potent therapeutic agents…”
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Conserved Antigenic Structure of Contemporary Wild Poliovirus Type 1 Strains Endemic in Pakistan
Published in The Journal of infectious diseases (13-09-2022)“…Abstract Background Elimination of poliovirus in Pakistan and Afghanistan is challenged by notions against the role of oral poliovirus vaccine (OPV) in…”
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Design and characterization of novel bis-benzamide liquid crystalline materials
Published in Journal of molecular structure (05-01-2018)“…A new homologous series of symmetric, bent-shaped bis-benzamide dimers have been prepared. Several 1,n-bis(p-aminophenoxy)alkanes (n = 3, 5, 9,10,11) were…”
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In Vitro and In Silico Approaches for the Evaluation of Antimicrobial Activity, Time-Kill Kinetics, and Anti-Biofilm Potential of Thymoquinone (2-Methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione) against Selected Human Pathogens
Published in Antibiotics (Basel) (10-01-2022)“…Thymoquinone (2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione; TQ), a principal bioactive phytoconstituent of essential oil, has been reported to have high…”
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Structure-Based Virtual Screening of Tumor Necrosis Factor-α Inhibitors by Cheminformatics Approaches and Bio-Molecular Simulation
Published in Biomolecules (Basel, Switzerland) (22-02-2021)“…Tumor necrosis factor-α (TNF-α) is a drug target in rheumatoid arthritis and several other auto-immune disorders. TNF-α binds with TNF receptors (TNFR),…”
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Design and Prototyping of Genetically Encoded Arsenic Biosensors Based on Transcriptional Regulator AfArsR
Published in Biomolecules (Basel, Switzerland) (26-08-2021)“…Genetically encoded biosensors based on engineered fluorescent proteins (FPs) are essential tools for monitoring the dynamics of specific ions and molecules in…”
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Theoretical Calculations on Hydroxybutyl 4-aroyloxybenzoates: Synthesis and Mesomorphic Properties of their H-bonded Complexes with Poly(4-vinylpyridine)
Published in Molecular Crystals and Liquid Crystals (13-04-2014)“…Important parameters of hydroxybutyl 4-aroyloxybenzoate ligands were calculated and correlations were made between theoretical and experimental results. In…”
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In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents
Published in PeerJ (San Francisco, CA) (08-03-2023)“…BackgroundMultidrug-resistant tuberculosis (MDR-TB) is one of the world’s most devastating contagious diseases and is caused by the MDR-Mycobacterium…”
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Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies
Published in European journal of medicinal chemistry (06-03-2015)“…In an effort to design and synthesize a new class of α-glucosidase inhibitor, we synthesized benzothiazole hybrid having benzohydrazide moiety (5). Compound 5…”
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Discovering potential stabilizers for KRAS22RT G-quadruplex DNA: an alternative next generation approach to treat pancreatic cancer
Published in Journal of biomolecular structure & dynamics (2023)“…KRAS is the signature gene responsible for the occurrence of pancreatic cancer, which is a complex, multifactorial and intractable lethal malignancy…”
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Synthesis, in vitro and computational studies of 1,4-disubstituted 1,2,3-triazoles as potential α-glucosidase inhibitors
Published in Bioorganic & medicinal chemistry letters (01-02-2016)“…[Display omitted] 1,4-Disubstituted-1,2,3-triazoles were synthesized by Cu(I) catalyzed click reaction, where the azides, with electron donating and electron…”
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In vitro and in silico evaluations of actinomycin X 2 and actinomycin D as potent anti-tuberculosis agents
Published in PeerJ (San Francisco, CA) (08-03-2023)“…Multidrug-resistant tuberculosis (MDR-TB) is one of the world's most devastating contagious diseases and is caused by the MDR- (MDR-Mtb) bacteria. It is…”
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In vitro and in silico evaluations of actinomycin X.sub.2 and actinomycin D as potent anti-tuberculosis agents
Published in PeerJ (San Francisco, CA) (08-03-2023)“…Background Multidrug-resistant tuberculosis (MDR-TB) is one of the world's most devastating contagious diseases and is caused by the MDR-Mycobacterium…”
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In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication
Published in Toxicology mechanisms and methods (02-01-2018)“…Organophosphate (OP) poisoning is a major global health issue; while compounds from this group have been used intensively over the last century, an effective…”
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The microbial hydroxylation of levonorgestrel
Published in Natural product research (01-10-2006)“…The microbial transformation of levonorgestrel (1) by Cunningham elegans resulted in the formation of five hydroxylated metabolites, 13-ethyl-10beta,…”
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The microbiological hydroxylation of levonorgestrel
Published in Natural product research (01-10-2006)“…The microbial transformation of levonorgestrel (1) by Cunninghamella elegans resulted in the formation of five hydroxylated metabolites,…”
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