Search Results - "FASCO, Michael"

Unique Cyanide Adduct in Human Serum Albumin: Potential as a Surrogate Exposure Marker by Fasco, Michael J, Stack, Robert F, Lu, Shijun, Hauer, Charles R, Schneider, Erasmus, Dailey, Michael, Aldous, Kenneth M

“…Cyanide (CN = HCN + CN−) is a renowned poison and neurotoxicant that is prevalent throughout the environment. Despite a plethora of studies conducted over the…”
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Phase I and II Carcinogen Metabolism Gene Expression in Human Lung Tissue and Tumors by SPIVACK, Simon D, HURTEAU, Gregory J, FASCO, Michael J, KAMINSKY, Laurence S

“…Purpose: The regulation of carcinogen metabolism machinery may involve proximate tobacco smoke exposure, hormonal and other endogenous coregulatory factors,…”
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Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue by Fasco, Michael J, Hurteau, Gregory J, Spivack, Simon D

“…Estrogen receptor (ER) expression in human lung has been understudied, particularly in light of its potential biological importance in the female lung cancer…”
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Differential action of polycyclic aromatic hydrocarbons on endogenous estrogen-responsive genes and on a transfected estrogen-responsive reporter in MCF-7 cells by Gozgit, Joseph M, Nestor, Kathleen M, Fasco, Michael J, Pentecost, Brian T, Arcaro, Kathleen F

“…Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants that have been extensively studied for multiple toxicological endpoints in both…”
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Cyanide Adducts with Human Plasma Proteins:  Albumin as a Potential Exposure Surrogate by Fasco, Michael J, Hauer, Charles R, Stack, Robert F, O'Hehir, Colleen, Barr, John R, Eadon, George A

“…Cyanide (CN) is a ubiquitous environmental toxicant. The measurement of CN in whole blood is a common exposure assay, but values are error prone because of…”
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Polycyclic Aromatic Hydrocarbon/Metal Mixtures: Effect on PAH Induction of CYP1A1 in Human HepG2 Cells by VAKHARIA, Dilip D, NING LIU, PAUSE, Ronald, FASCO, Michael, BESSETTE, Erin, ZHANG, Qing-Yu, KAMINSKY, Laurence S

“…Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification…”
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Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: The role of heme oxygenase-1 by Bessette, Erin E., Fasco, Michael J., Pentecost, Brian T., Reilly, Andrew, Kaminsky, Laurence S.

“…Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH‐mediated upregulation of human CYP1A1, the enzyme that…”
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MECHANISMS OF ARSENITE-MEDIATED DECREASES IN BENZO[K]FLUORANTHENE-INDUCED HUMAN CYTOCHROME P4501A1 LEVELS IN HEPG2 CELLS by BESSETTE, Erin E, FASCO, Michael J, PENTECOST, Brian T, KAMINSKY, Laurence S

“…Polycyclic aromatic hydrocarbons (PAHs) and heavy metals are often environmental cocontaminants that could interact to alter PAH carcinogenicity. The heavy…”
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Effect of Metals on Polycyclic Aromatic Hydrocarbon Induction of CYP1A1 and CYP1A2 in Human Hepatocyte Cultures by Vakharia, Dilip D., Liu, Ning, Pause, Ronald, Fasco, Michael, Bessette, Erin, Zhang, Qing-Yu, Kaminsky, Laurence S.

“…Environmental cocontamination by polycyclic aromatic hydrocarbons (PAHs) and metals could affect the carcinogenic consequences of PAH exposure by modifying PAH…”
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Optimization of Dnase I removal of contaminating DNA from RNA for use in quantitative RNA-PCR by Huang, Z, Fasco, M J, Kaminsky, L S

“…In competitive RNA-PCR studies, contaminating DNA can produce incorrect results because of its potential to act as a second competitor. Preliminary studies…”
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Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs by Meng, Quanxin, Olivero, Ofelia A., Fasco, Michael J., Bellisario, Ronald, Kaminsky, Laurence, Pass, Ken A., Wade, Nancy A., Abrams, Elaine J., Nesel, Carol J., Ness, Roberta B., Bigbee, William L., O'Neill, J. Patrick, Walker, Dale M., Poirier, Miriam C., Walker, Vernon E.

“…Several systemic and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT) metabolism and AZT incorporation into nuclear DNA were measured in cord blood from…”
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Phenotypic changes in MCF-7 cells during prolonged exposure to tamoxifen by Fasco, Michael J., Amin, Agita, Pentecost, Brian T., Yang, Yi, Gierthy, John F.

“…MCF-7 breast tumor cells form multicellular nodules (foci) over a confluent monolayer in an estradiol (E2)-dependent, antiestrogen-sensitive reaction. A cell…”
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Regulation of Cytochrome P4501A1 Expression in Rat Small Intestine by ZHANG, Q.-Y, WIKOFF, J, DUNBAR, D, FASCO, M, KAMINSKY, L

“…The predominant inducible cytochrome P450 (CYP) in rat small intestine is CYP1A1, which, when induced to elevated levels by xenobiotics or dietary…”
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Estrogen receptor mRNA splice variants produced from the distal and proximal promoter transcripts by Fasco, Michael J

“…Relative proportions of the estrogen receptor (ER) alternatively spliced mRNA variants from the proximal (A) and distal (B) promoter pre-mRNA transcripts were…”
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Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues by HUANG, Z, FASCO, M. J, SPIVACK, S, KAMINSKY, L. S

“…Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human…”
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Alternative Splicing of CYP2D mRNA in Human Breast Tissue by Huang, Zeqi, Fasco, Michael J., Kaminsky, Laurence S.

“…The human cytochrome P450 (CYP) 2D subfamily comprises theCYP2D6gene and four pseudogenes,CYP2D7P1and2andCYP2D8P1and2.TheCYP2D6gene product is a prominent…”
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Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes by Fasco, Michael J, Principe, Louise M, Walsh, William A, Friedman, Paul A

“…Warfarin is a potent inhibitor of vitamin K 2,3-epoxide reduction to vitamin K in vitro and in vivo. Dithiothreitol, an in vitro reductant for the vitamin K…”
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Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide by Lee, Jung Ja, Fasco, Michael J

“…The effects of thiols and sulfhydryl blocking reagents on the reduction of vitamin K to vitamin K hydroquinone and vitamin K 2,3-epoxide to vitamin K and…”
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Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells by SPINK, D. C, SPINK, B. C, CAO, J. Q, DEPASQUALE, J. A, PENTECOST, B. T, FASCO, M. J, YING LI, SUTTER, T. R

“…Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic activation of a number of procarcinogens and the hydroxylation of…”
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Expression of cytochromes P450 in human breast tissue and tumors by Huang, Z, Fasco, M J, Figge, H L, Keyomarsi, K, Kaminsky, L S

“…In an effort to determine which members of the cytochrome P450 (CYP) superfamily are expressed in human breast tissue and tumors, RNA-polymerase chain reaction…”
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