Search Results - "FARZAN, Michael"

The broad-spectrum antiviral functions of IFIT and IFITM proteins by Diamond, Michael S., Farzan, Michael

“…Key Points IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3…”
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Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2 by Ou, Tianling, Mou, Huihui, Zhang, Lizhou, Ojha, Amrita, Choe, Hyeryun, Farzan, Michael

“…Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in…”
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity by Zhang, Lizhou, Jackson, Cody B., Mou, Huihui, Ojha, Amrita, Peng, Haiyong, Quinlan, Brian D., Rangarajan, Erumbi S., Pan, Andi, Vanderheiden, Abigail, Suthar, Mehul S., Li, Wenhui, Izard, Tina, Rader, Christoph, Farzan, Michael, Choe, Hyeryun

“…SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S G614 )…”
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SARS-CoV-2 and Three Related Coronaviruses Utilize Multiple ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig by Li, Yujun, Wang, Haimin, Tang, Xiaojuan, Fang, Shisong, Ma, Danting, Du, Chengzhi, Wang, Yifei, Pan, Hong, Yao, Weitong, Zhang, Renli, Zou, Xuan, Zheng, Jie, Xu, Liangde, Farzan, Michael, Zhong, Guocai

“…The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused >20 million infections and >750,000 deaths. Severe acute respiratory syndrome coronavirus 2…”
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Ifitm3 limits the severity of acute influenza in mice by Bailey, Charles C, Huang, I-Chueh, Kam, Christina, Farzan, Michael

“…Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses,…”
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IFITM-Family Proteins: The Cell's First Line of Antiviral Defense by Bailey, Charles C, Zhong, Guocai, Huang, I-Chueh, Farzan, Michael

“…Animal cells use a wide variety of mechanisms to slow or prevent replication of viruses. These mechanisms are usually mediated by antiviral proteins whose…”
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Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors by Tickner, Zachary J, Farzan, Michael

“…Vectors developed from adeno-associated virus (AAV) are powerful tools for in vivo transgene delivery in both humans and animal models, and several…”
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A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent by Xiao, Tianshu, Lu, Jianming, Zhang, Jun, Johnson, Rebecca I., McKay, Lindsay G. A., Storm, Nadia, Lavine, Christy L., Peng, Hanqin, Cai, Yongfei, Rits-Volloch, Sophia, Lu, Shen, Quinlan, Brian D., Farzan, Michael, Seaman, Michael S., Griffiths, Anthony, Chen, Bing

“…Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound…”
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Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses by Richard, Audrey Stéphanie, Zhang, Adam, Park, Sun-Jin, Farzan, Michael, Zong, Min, Choe, Hyeryun

“…Phosphatidylserine (PS) receptors contribute to two crucial biological processes: apoptotic clearance and entry of many enveloped viruses. In both cases, they…”
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The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral Entry by Amini-Bavil-Olyaee, Samad, Choi, Youn Jung, Lee, Jun Han, Shi, Mude, Huang, I-Chueh, Farzan, Michael, Jung, Jae U.

“…Vesicle-membrane-protein-associated protein A (VAPA) and oxysterol-binding protein (OSBP) regulate intracellular cholesterol homeostasis, which is required for…”
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Dual host-virus arms races shape an essential housekeeping protein by Demogines, Ann, Abraham, Jonathan, Choe, Hyeryun, Farzan, Michael, Sawyer, Sara L

“…Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also…”
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Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I by Gack, Michaela Ulrike, Albrecht, Randy Allen, Urano, Tomohiko, Inn, Kyung-Soo, Huang, I-Chueh, Carnero, Elena, Farzan, Michael, Inoue, Satoshi, Jung, Jae Ung, García-Sastre, Adolfo

“…The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I…”
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The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus by Brass, Abraham L., Huang, I-Chueh, Benita, Yair, John, Sinu P., Krishnan, Manoj N., Feeley, Eric M., Ryan, Bethany J., Weyer, Jessica L., van der Weyden, Louise, Fikrig, Erol, Adams, David J., Xavier, Ramnik J., Farzan, Michael, Elledge, Stephen J.

“…Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction…”
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Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats by DEMOGINES, Ann, FARZAN, Michael, SAWYER, Sara L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine by Jemielity, Stephanie, Wang, Jinyize J, Chan, Ying Kai, Ahmed, Asim A, Li, Wenhui, Monahan, Sheena, Bu, Xia, Farzan, Michael, Freeman, Gordon J, Umetsu, Dale T, Dekruyff, Rosemarie H, Choe, Hyeryun

“…Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as…”
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In vitro affinity maturation of broader and more-potent variants of the HIV-1–neutralizing antibody CAP256-VRC26.25 by Yin, Yiming, Quinlan, Brian D., Ou, Tianling, Guo, Yan, He, Wenhui, Farzan, Michael

“…Three variable 2 (V2) loops of HIV-1 envelope glycoprotein (Env) trimer converge at the Env apex to form the epitope of an important classes of HIV-1 broadly…”
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Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells by Zhong, Guocai, Wang, Haimin, Bailey, Charles C, Gao, Guangping, Farzan, Michael

“…Efforts to control mammalian gene expression with ligand-responsive riboswitches have been hindered by lack of a general method for generating efficient…”
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Interferon-induced Transmembrane Protein 3 Is a Type II Transmembrane Protein by Bailey, Charles C., Kondur, Hema R., Huang, I-Chueh, Farzan, Michael

“…The interferon-induced transmembrane (IFITM) proteins are a family of small membrane proteins that inhibit the cellular entry of several genera of viruses…”
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Correction: Tickner, Z.J.; Farzan, M. Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors. Pharmaceuticals 2021, 14 , 554 by Tickner, Zachary J, Farzan, Michael

“…In the original article, Renzl, C [...]…”
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A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies by Davis-Gardner, Meredith E, Alfant, Barnett, Weber, Jesse A, Gardner, Matthew R, Farzan, Michael

“…Broadly neutralizing antibodies (bNAbs) can prevent and control an HIV-1 infection, but their breadth is invariably too limited for use as monotherapy. To…”
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