Search Results - "FARRER, L. A"

Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci by Gelernter, J, Kranzler, H R, Sherva, R, Almasy, L, Koesterer, R, Smith, A H, Anton, R, Preuss, U W, Ridinger, M, Rujescu, D, Wodarz, N, Zill, P, Zhao, H, Farrer, L A

“…We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs,…”
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Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1 by Smith, A H, Jensen, K P, Li, J, Nunez, Y, Farrer, L A, Hakonarson, H, Cook-Sather, S D, Kranzler, H R, Gelernter, J

“…Opioids are very effective analgesics, but they are also highly addictive. Methadone is used to treat opioid dependence (OD), acting as a selective agonist at…”
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Head circumference, atrophy, and cognition: Implications for brain reserve in Alzheimer disease by PERNECZKY, R, WAGENPFEIL, S, LUNETTA, K. L, CUPPLES, L. A, GREEN, R. C, DECARLI, C, FARRER, L. A, KURZ, A

“…Clinical and epidemiologic studies suggest that patients with Alzheimer disease (AD) with larger head circumference have better cognitive performance at the…”
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Postmenopausal hormone therapy and Alzheimer’s disease risk: interaction with age by Henderson, V W, Benke, K S, Green, R C, Cupples, L A, Farrer, L A

“…We examined the relation between oestrogen containing hormone therapy (HT) used for more than 6 months and Alzheimer’s disease (AD) risk in 971 postmenopausal…”
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Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment by Nho, K, Corneveaux, J J, Kim, S, Lin, H, Risacher, S L, Shen, L, Swaminathan, S, Ramanan, V K, Liu, Y, Foroud, T, Inlow, M H, Siniard, A L, Reiman, R A, Aisen, P S, Petersen, R C, Green, R C, Jack, C R, Weiner, M W, Baldwin, C T, Lunetta, K, Farrer, L A, Furney, S J, Lovestone, S, Simmons, A, Mecocci, P, Vellas, B, Tsolaki, M, Kloszewska, I, Soininen, H, McDonald, B C, Farlow, M R, Ghetti, B, Huentelman, M J, Saykin, A J

“…Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the…”
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APOE, vascular pathology, and the AD brain by YIP, A. G, MCKEE, A. C, GREEN, R. C, WELLS, J, YOUNG, H, CUPPLES, L. A, FARRER, L. A

“…To use neuropathologic data to examine the association between APOE genotype and cerebrovascular lesions commonly found in Alzheimer disease (AD), as well as…”
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Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP) by Reitz, C, Tosto, G, Vardarajan, B, Rogaeva, E, Ghani, M, Rogers, R S, Conrad, C, Haines, J L, Pericak-Vance, M A, Fallin, M D, Foroud, T, Farrer, L A, Schellenberg, G D, George-Hyslop, P S, Mayeux, R

“…Genetic variants in the sortilin-related receptor ( SORL1 ) and the sortilin-related vacuolar protein sorting 10 (VPS10) domain-containing receptor 1 ( SORCS1…”
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No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples by Chang, S-C, Xie, P, Anton, R F, De Vivo, I, Farrer, L A, Kranzler, H R, Oslin, D, Purcell, S M, Roberts, A L, Smoller, J W, Uddin, M, Gelernter, J, Koenen, K C

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Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea by Ma, Q, Wyszynski, D F, Farrell, J J, Kutlar, A, Farrer, L A, Baldwin, C T, Steinberg, M H

“…The increase in fetal hemoglobin (HbF) in response to hydroxyurea (HU) varies among patients with sickle cell anemia. Twenty-nine candidate genes within loci…”
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Head injury and the risk of AD in the MIRAGE study by GUO, Z, CUPPLES, L. A, JOHNSON, K, GO, R. C, GROWDON, J. H, HAINES, J. L, KUKULL, W. A, FARRER, L. A, KURZ, A, AUERBACH, S. H, VOLICER, L, CHUI, H, GREEN, R. C, SADOVNICK, A. D, DUARA, R, DECARLI, C

“…It has been suggested in some studies that head injury is a risk factor for AD, and that this risk is heightened among carriers of the APOE-epsilon4 allele. We…”
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Hypertension increases the probability of Alzheimer's disease and of mild cognitive impairment in an Arab community in northern Israel by Israeli-Korn, S D, Masarwa, M, Schechtman, E, Abuful, A, Strugatsky, R, Avni, S, Farrer, L A, Friedland, R P, Inzelberg, R

“…We aimed to determine whether vascular risk factors are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in an elderly Arab…”
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β-Globin gene cluster polymorphisms are strongly associated with severity of HbE/β°-thalassemia by MA, Q, ABEL, K, SRIPICHAI, O, WHITACRE, J, ANGKACHATCHAI, V, MAKARASARA, W, WINICHAGOON, P, FUCHAROEN, S, BRNUN, A, FARRER, L. A

“…We evaluated the contribution of 67 single nucleotide polymorphisms (SNPs) within the beta-globin gene cluster to disease severity in groups of 207 mild- and…”
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Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics by Nho, K, Corneveaux, J J, Kim, S, Lin, H, Risacher, S L, Shen, L, Swaminathan, S, Ramanan, V K, Liu, Y, Foroud, T, Inlow, M H, Siniard, A L, Reiman, R A, Aisen, P S, Petersen, R C, Green, R C, Jack, C R, Weiner, M W, Baldwin, C T, Lunetta, K, Farrer, L A, Furney, S J, Lovestone, S, Simmons, A, Mecocci, P, Vellas, B, Tsolaki, M, Kloszewska, I, Soininen, H, McDonald, B C, Farlow, M R, Ghetti, B, Huentelman, M J, Saykin, A J

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Comparison of Alzheimer's disease risk factors in white and African American families by BACHMAN, D. L, GREEN, R. C, BENKE, K. S, CUPPLES, L. A, FARRER, L. A

“…The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were…”
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Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study : What is in store for the oldest old ? by LAUTENSCHLAGER, N. T, CUPPLES, L. A, GREEN, R. C, JONES, R, KARLINSKY, H, KUKULL, W. A, KURZ, A, LARSON, E. B, MARTELLI, K, SADOVNICK, A. D, VOLICER, L, WARING, S. C, RAO, V. S, GROWDON, J. H, FARRER, L. A, AUERBACH, S. A, BECKER, R, BURKE, J, CHUI, H, DUARA, R, FOLEY, E. J, GLATT, S. L

“…Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely,…”
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Genetic association between endothelial nitric oxide synthase and Alzheimer disease by Akomolafe, A, Lunetta, KL, Erlich, PM, Cupples, LA, Baldwin, CT, Huyck, M, Green, RC, Farrer, LA

“…Evidence suggests that vascular and inflammatory factors may be important in the etiology of Alzheimer disease (AD). The Glu/Glu genotype at the Glu298Asp…”
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Genome-wide association study identifies a novel locus for cannabis dependence by Agrawal, A, Chou, Y-L, Carey, C E, Baranger, D A A, Zhang, B, Sherva, R, Wetherill, L, Kapoor, M, Wang, J-C, Bertelsen, S, Anokhin, A P, Hesselbrock, V, Kramer, J, Lynskey, M T, Meyers, J L, Nurnberger, J I, Rice, J P, Tischfield, J, Bierut, L J, Degenhardt, L, Farrer, L A, Gelernter, J, Hariri, A R, Heath, A C, Kranzler, H R, Madden, P A F, Martin, N G, Montgomery, G W, Porjesz, B, Wang, T, Whitfield, J B, Edenberg, H J, Foroud, T, Goate, A M, Bogdan, R, Nelson, E C

“…Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of…”
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The Alzheimer's Disease Sequencing Project: Study design and sample selection by Beecham, Gary W, Bis, J C, Martin, E R, Choi, S-H, DeStefano, A L, van Duijn, C M, Fornage, M, Gabriel, S B, Koboldt, D C, Larson, D E, Naj, A C, Psaty, B M, Salerno, W, Bush, W S, Foroud, T M, Wijsman, E, Farrer, L A, Goate, A, Haines, J L, Pericak-Vance, Margaret A, Boerwinkle, E, Mayeux, R, Seshadri, S, Schellenberg, G

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A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke by Jensen, K P, Smith, A H, Herman, A I, Farrer, L A, Kranzler, H R, Sofuoglu, M, Gelernter, J

“…Nicotine withdrawal symptoms contribute to relapse in smokers, thereby prolonging the harm caused by smoking. To investigate the molecular basis for this…”
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Evidence for an Alzheimer Disease Susceptibility Locus on Chromosome 12 and for Further Locus Heterogeneity by Rogaeva, Ekaterina, Premkumar, Smita, Song, Youqiang, Sorbi, Sandro, Brindle, Nicholas, Paterson, Andrew, Duara, Ranjan, Levesque, Georges, Yu, Gang, Nishimura, Masaki, Ikeda, Masaki, O'Toole, Colleen, Kawarai, Toshitaka, Jorge, Ricardo, Vilarino, Daniel, Bruni, Amalia C, Farrer, Lindsay A, St. George-Hyslop, Peter H

“…CONTEXT.— Alzheimer disease (AD) susceptibility genes have been identified on chromosomes 1, 14, 19, and 21, and a recent study has suggested a locus on…”
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