Search Results - "FARRELL, W. E"

Epigenetic control of fetal gene expression by NAFEE, T. M, FARRELL, W. E, CARROLL, W. D, FRYER, A. A, ISMAIL, K. M. K

“…Each differentiated cell type has its own epigenetic signature, which reflects its genotype, developmental history, and environmental influences, and is…”
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What do deep sea pressure fluctuations tell about short surface waves? by Farrell, W. E., Munk, Walter

“…Short waves centered at the gravity to capillary transition (13.5 Hz) dominate the slope statistics of the sea surface and are responsible for most of the…”
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Pituitary tumours: findings from whole genome analyses by Farrell, W E

“…Pituitary tumours are common intracranial neoplasms that cause significant morbidity through mass effects and/or the inappropriate secretion of pituitary…”
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Pituitary tumours: all silent on the epigenetics front by Dudley, K J, Revill, K, Clayton, R N, Farrell, W E

“…Investigation of the epigenome of sporadic pituitary tumours is providing a more detailed understanding of aberrations that characterise this tumour type…”
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Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma by Revill, K, Dudley, K J, Clayton, R N, McNicol, A M, Farrell, W E

“…The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation…”
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Preferential loss of Death Associated Protein kinase expression in invasive pituitary tumours is associated with either CpG island methylation or homozygous deletion by SIMPSON, D. J, CLAYTON, R. N, FARRELL, W. E

“…Death Associated Protein kinase (DAP kinase) a novel calmodulin-dependent serine/threonine kinase was first identified as a positive mediator of programmed…”
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Epigenetic change in pituitary tumorigenesis by Farrell, W E, Clayton, R N

“…Throughout the genome CpG dinucleotides are found at one-fifth of their expected frequency and their rarity is further marked by the fact that 70% are…”
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Epigenetic mechanisms of tumorigenesis by Farrell, W E

“…In the majority of human cancers, heritable loss of gene function through cell division may be mediated as often by epigenetic as by genetic abnormalities…”
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Bromocriptine and dopamine mediate independent and synergistic apoptotic pathways in pituitary cells by Rowther, F B, Richardson, A, Clayton, R N, Farrell, W E

“…Dopamine (DA) agonists are the primary treatment choice for prolactinoma, effectively suppressing prolactin expression and reducing tumour size. However, the…”
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Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island by SIMPSON, D. J, HIBBERTS, N. A, MCNICOL, A. M, CLAYTON, R. N, FARRELL, W. E

“…We recently showed loss of pRb in a proportion of pituitary tumors that was not associated with loss of heterozygosity of an RB1 intragenic marker. To further…”
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Pituitary tumours by Davis, Farrell, WE, Clayton, RN

“…Pituitary tumours are a common type of intracranial neoplasm and, depending on the cell type of origin, have diverse endocrine and reproductive effects. The…”
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Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker by BATES, A. S, FARRELL, W. E, BICKNELL, E. J, MCNICOL, A. M, TALBOT, A. J, BROOME, J. C, PERRETT, C. W, THAKKER, R. V, CLAYTON, R. N

“…Tumors of the pituitary gland are usually benign adenomas and account for 10% of all intracranial neoplasms. Five pituitary tumors have previously been…”
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Surface gravity waves and their acoustic signatures, 1-30 Hz, on the mid-Pacific sea floor by Farrell, W E, Munk, Walter

“…In 1999, Duennebier et al. deployed a hydrophone and geophone below the conjugate depth in the abyssal Pacific, midway between Hawaii and California. Real time…”
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A novel apoptosis gene identified in the pituitary gland by Farrell, W E

“…Although multiple different cancers have been described, it is likely that these tumour types share a small, and common, number of newly acquired functional…”
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Cyclin D1 (CCND1) genotype is associated with tumour grade in sporadic pituitary adenomas by Simpson, D.J., Fryer, A.A., Grossman, A.B., Wass, J.A.H., Pfeifer, M., Kros, J.M., Clayton, R.N., Farrell, W.E.

“…The cyclin D1 (CCND1) gene contains a frequent A/G polymorphism within the splice donor region of exon 4/intron 4. CCND1 genotype is associated with clinical…”
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The WHO typing of pituitary tumors: a commentary by Farrell, W E

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A deep ocean acoustic noise floor, 1–800 Hz by Berger, J., Bidlot, J.-R., Dzieciuch, M. A., Farrell, W. E., Worcester, P. F., Stephen, R. A.

“…The ocean acoustic noise floor (observed when the overhead wind is low, ships are distant, and marine life silent) has been measured on an array extending up…”
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Analysis of Cyclin D1 (CCND1) Allelic Imbalance and Overexpression in Sporadic Human Pituitary Tumors by HIBBERTS, N. A, SIMPSON, D. J, BICKNELL, J. E, BROOME, J. C, HOBAN, P. R, CLAYTON, R. N, FARRELL, W. E

“…Cyclin D1 plays an important role in the regulation of cell progression through G 1 of the cell cycle and has been demonstrated to have oncogenic properties…”
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Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours by FARRELL, W. E, SIMPSON, D. J, BICKNELL, J, MAGNAY, J. L, KYRODIMOU, E, THAKKER, R. V, CLAYTON, R. N

“…The majority of pituitary tumours are monoclonal in origin and arise sporadically or occasionally as part of multiple endocrine neoplasia type 1 (MEN1). Whilst…”
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Chromosome 13q deletion mapping in pituitary tumors : Infrequent loss of the retinoblastoma susceptibility gene (RB1) locus despite loss of RB1 protein product in somatotrophinomas by SIMPSON, D. J, MAGNAY, J, BICKNELL, J. E, BARKAN, A. L, MCNICOL, A. M, CLAYTON, R. N, FARRELL, W. E

“…Two recent studies have described allelic loss of an RB1 intragenic marker on chromosome 13q in aggressive and metastatic pituitary tumors that did not…”
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