Search Results - "FARRELL, F. X"

Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin by Wrighton, Nicholas C., Farrell, Francis X., Chang, Ray, Kashyap, Arun K., Barbone, Francis P., Mulcahy, Linda S., Johnson, Dana L., Barrett, Ronald W., Jolliffe, Linda K., Dower, William J.

“…Random phage display peptide libraries and affinity selective methods were used to isolate small peptides that bind to and activate the receptor for the…”
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Increased potency of an erythropoietin peptide mimetic through covalent dimerization by Wrighton, Nicholas C, Balasubramanian, Palaniappan, Barbone, Francis P, Kashyap, Arun K, Farrell, Francis X, Jolliffe, Linda K, Barrett, Ronald W, Dower, William J

“…We have synthesized a chemically defined, dimeric form of an erythropoietin mimetic peptide (EMP) that displays 100-fold increased affinity for the…”
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New epoetin molecules and novel therapeutic approaches by Barbone, F P, Johnson, D L, Farrell, F X, Collins, A, Middleton, S A, McMahon, F J, Tullai, J, Jolliffe, L K

“…Erythropoietin (EPO) is a 34 kDa protein that is the primary regulator of red blood cell production. EPO facilitates its effect by binding to the cell surface…”
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A negative element involved in vimentin gene expression by FARRELL, F. X, SAX, C. M, ZEHNER, Z. E

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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BMP-7 fails to attenuate TGF- 1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells by Dudas, P. L., Argentieri, R. L., Farrell, F. X.

“…Background. In rodent models of chronic renal disease bone morphogenetic protein-7 (BMP-7) has been shown to halt disease progression and promote recovery…”
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RAP2B: A RAS-Related GTP-Binding Protein from Platelets by Ohmstede, Carol-Ann, Farrell, Francis X., Reep, Bryan R., Clemetson, Kenneth J., Lapetina, Eduardo G.

“…A platelet cDNA expression library was screened with the monoclonal antibody M90, which recognizes a specific epitope on RAS-encoded p21 proteins (amino acids…”
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Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated by Farrell, F X, Yamamoto, K, Lapetina, E G

“…Rap proteins comprise a subset of the large family of ras-related proteins. They contain the C-terminal tetrapeptide sequence motif Cys-Ali-Ali-Xaa (Ali is an…”
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Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids by Connolly, Peter J, Wetter, Steven K, Murray, William V, Johnson, Dana L, McMahon, Frank J, Farrell, Francis X, Tullai, Jennifer, Jolliffe, Linda K

“…N,N-Dicinnamyl, N-benzyl- N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid,…”
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Microinjection of Rap2B protein or RNA induces rearrangement of pigment granules in Xenopus oocytes by CAMPA, M. J, FARRELL, F. X, LAPETINA, E. G, CHANG, K.-J

“…Rap2B, a member of the ras superfamily of low-molecular-mass GTP-binding proteins, induced a characteristic rearrangement of the pigment granules in Xenopus…”
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cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2 by FARRELL, F. X, OHMSTEDE, C.-A, REEP, B. R, LAPETINA, E. G

“…The existence of several low molecular weight GTP-binding proteins in platelets has been documented. We have shown these proteins can be phosphorylated and…”
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Partial purification of a GTPase-activating protein for rap2b from bovine brain membranes by Farrell, F X, Lapetina, E G

“…Rap2b is a ras-related GTP-binding protein isolated from a human platelet cDNA library. It shares 90% similarity to the previously described rap2a and is…”
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Down-regulation of vimentin gene expression during myogenesis is controlled by a 5'-flanking sequence by Sax, C M, Farrell, F X, Zehner, Z E

“…During myogenesis, the intermediate filament proteins vimentin and desmin are differentially expressed. While desmin levels increase dramatically, vimentin…”
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Rap1b and platelet function by Lapetina, E G, Farrell, F X

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Multiple elements are required for expression of an intermediate filament gene by SAX, C. M, FARRELL, F. X, TOBIAN, J. A, ZEHNER, Z. E

“…The expression of vimentin is unique within the intermediate filament multigene family. It is the only member which deviates from its usual tissue-specific…”
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Identification of a 13 Amino Acid Peptide Mimetic of Erythropoietin and Description of Amino Acids Critical for the Mimetic Activity of EMP1 by Johnson, Dana L, Farrell, Francis X, Barbone, Francis P, McMahon, Frank J, Tullai, Jennifer, Hoey, Kenway, Livnah, Oded, Wrighton, Nicholas C, Middleton, Steven A, Loughney, Deborah A, Stura, Enrico A, Dower, William J, Mulcahy, Linda S, Wilson, Ian A, Jolliffe, Linda K

“…To obtain information about the functional importance of amino acids required for effective erythropoietin (EPO) mimetic action, the conserved residues of a…”
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An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation by Jolliffe, Linda K, Wilson, Ian A, Livnah, Oded, Johnson, Dana L, Stura, Enrico A, Farrell, Francis X, Barbone, Francis P, You, Yun, Liu, Kathleen D, Goldsmith, Mark A, He, Wen, Krause, Christopher D, Pestka, Sidney

“…Dimerization of the erythropoietin (EPO) receptor (EPOR), in the presence of either natural (EPO) or synthetic (EPO-mimetic peptides, EMPs) ligands is the…”
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Shared and Unique Determinants of the Erythropoietin (EPO) Receptor Are Important for Binding EPO and EPO Mimetic Peptide by Middleton, Steven A., Barbone, Francis P., Johnson, Dana L., Thurmond, Robin L., You, Yun, McMahon, Frank J., Jin, Renzhe, Livnah, Oded, Tullai, Jennifer, Farrell, Francis X., Goldsmith, Mark A., Wilson, Ian A., Jolliffe, Linda K.

“…We have shown previously that Phe93 in the extracellular domain of the erythropoietin (EPO) receptor (EPOR) is crucial for binding EPO. Substitution of Phe93…”
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Erythropoietin induces changes in gene expression in PC-12 cells by Renzi, Michael J, Farrell, Francis X, Bittner, Anton, Galindo, Jose E, Morton, Mike, Trinh, Heather, Jolliffe, Linda K

“…Erythropoietin (EPO) is the primary modulator of red blood cell production. Recently EPO has received considerable attention for its functions outside of…”
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Regulation of vimentin gene expression in the ocular lens by Sax, Christina M., Farrell, Francis X., Zehner, Zendra E., Piatigorsky, Joram

“…Vimentin expression in the lens is striking due to the reported mesenchymal preference of vimentin and the epithelial origin of the lens. The amount of chicken…”
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Recombinant epoetins do not stimulate tumor growth in erythropoietin receptor–positive breast carcinoma models by LaMontagne, Kenneth R, Butler, Jeannene, Marshall, Deborah J, Tullai, Jennifer, Gechtman, Ze'ev, Hall, Chassidy, Meshaw, Alan, Farrell, Francis X

“…We investigated the significance of erythropoietin receptor (EPOR) expression following treatment with recombinant human erythropoietin (rHuEPO; epoetin α) and…”
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