Search Results - "FARR, Tracy D"

Novel targets, treatments, and advanced models for intracerebral haemorrhage by Zille, Marietta, Farr, Tracy D., Keep, Richard F., Römer, Christine, Xi, Guohua, Boltze, Johannes

“…Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major cause of mortality and disability worldwide. Despite advances in surgical…”
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Atlas registration for edema-corrected MRI lesion volume in mouse stroke models by Koch, Stefan, Mueller, Susanne, Foddis, Marco, Bienert, Thomas, von Elverfeldt, Dominik, Knab, Felix, Farr, Tracy D, Bernard, René, Dopatka, Monika, Rex, André, Dirnagl, Ulrich, Harms, Christoph, Boehm-Sturm, Philipp

“…Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a…”
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Visualizing Cell Death in Experimental Focal Cerebral Ischemia: Promises, Problems, and Perspectives by Zille, Marietta, Farr, Tracy D, Przesdzing, Ingo, Müller, Jochen, Sommer, Clemens, Dirnagl, Ulrich, Wunder, Andreas

“…One of the hallmarks of stroke pathophysiology is the widespread death of many different types of brain cells. As our understanding of the complex disease that…”
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Use of magnetic resonance imaging to predict outcome after stroke: a review of experimental and clinical evidence by Farr, Tracy D, Wegener, Susanne

“…Despite promising results in preclinical stroke research, translation of experimental data into clinical therapy has been difficult. One reason is the…”
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Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment by Dam, Kevin, Füchtemeier, Martina, Farr, Tracy D., Boehm-Sturm, Philipp, Foddis, Marco, Dirnagl, Ulrich, Malysheva, Olga, Caudill, Marie A., Jadavji, Nafisa M.

“…•Mthfr+/− mice fed FADD with microcoils (VCI) had impaired reference memory.•All FADD mice had elevated levels of plasma homocysteine.•Arterial remodeling was…”
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High field BOLD response to forepaw stimulation in the mouse by Adamczak, Joanna M., Farr, Tracy D., Seehafer, Jörg U., Kalthoff, Daniel, Hoehn, Mathias

“…We have established a robust protocol for longitudinal fMRI in mice at high field MRI using a medetomidine anesthesia. Electrical forepaw stimulation in…”
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Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology by Horsburgh, Karen, Wardlaw, Joanna M, van Agtmael, Tom, Allan, Stuart M, Ashford, Mike L J, Bath, Philip M, Brown, Rosalind, Berwick, Jason, Cader, M Zameel, Carare, Roxana O, Davis, John B, Duncombe, Jessica, Farr, Tracy D, Fowler, Jill H, Goense, Jozien, Granata, Alessandra, Hall, Catherine N, Hainsworth, Atticus H, Harvey, Adam, Hawkes, Cheryl A, Joutel, Anne, Kalaria, Rajesh N, Kehoe, Patrick G, Lawrence, Catherine B, Lockhart, Andy, Love, Seth, Macleod, Malcolm R, Macrae, I Mhairi, Markus, Hugh S, McCabe, Chris, McColl, Barry W, Meakin, Paul J, Miller, Alyson, Nedergaard, Maiken, O'Sullivan, Michael, Quinn, Terry J, Rajani, Rikesh, Saksida, Lisa M, Smith, Colin, Smith, Kenneth J, Touyz, Rhian M, Trueman, Rebecca C, Wang, Tao, Williams, Anna, Williams, Steven C R, Work, Lorraine M

“…Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a…”
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Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment by Boehm-Sturm, Philipp, Füchtemeier, Martina, Foddis, Marco, Mueller, Susanne, Trueman, Rebecca C, Zille, Marietta, Rinnenthal, Jan Leo, Kypraios, Theodore, Shaw, Laurence, Dirnagl, Ulrich, Farr, Tracy D

“…BACKGROUND AND PURPOSE—Chronic hypoperfusion in the mouse brain has been suggested to mimic aspects of vascular cognitive impairment, such as white matter…”
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Vascular Change and Opposing Effects of the Angiotensin Type 2 Receptor in a Mouse Model of Vascular Cognitive Impairment by Füchtemeier, Martina, Brinckmann, Marie P, Foddis, Marco, Kunz, Alexander, Po, Chrystelle, Curato, Caterina, Dirnagl, Ulrich, Farr, Tracy D

“…Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and…”
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Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells by Ogrodzinski, Lydia, Platt, Simon, Goulding, Joelle, Alexander, Cameron, Farr, Tracy D., Woolard, Jeanette, Hill, Stephen J., Kilpatrick, Laura E.

“…E-selectin is expressed on endothelial cells in response to inflammatory cytokines and mediates leukocyte rolling and extravasation. However, studies have been…”
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Bilateral alteration in stepping pattern after unilateral motor cortex injury: A new test strategy for analysis of skilled limb movements in neurological mouse models by Farr, Tracy D., Liu, Lily, Colwell, Keri L., Whishaw, Ian Q., Metz, Gerlinde A.

“…Mice are becoming increasingly popular to model neurological disease and motor system dysfunction. For evaluation of discrete, chronic motor impairments,…”
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Bioluminescence imaging of stroke-induced endogenous neural stem cell response by Vandeputte, Caroline, Reumers, Veerle, Aelvoet, Sarah-Ann, Thiry, Irina, De Swaef, Sylvie, Van den Haute, Chris, Pascual-Brazo, Jesus, Farr, Tracy D, Vande Velde, Greetje, Hoehn, Mathias, Himmelreich, Uwe, Van Laere, Koen, Debyser, Zeger, Gijsbers, Rik, Baekelandt, Veerle

“…Abstract Brain injury following stroke affects neurogenesis in the adult mammalian brain. However, a complete understanding of the origin and fate of the…”
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Quantitative and qualitative impairments in skilled reaching in the mouse (Mus musculus) after a focal motor cortex stroke by FARR, Tracy D, WHISHAW, Ian Q

“…Skilled reaching movements are an important aspect of human motor behavior but are impaired after motor system stroke. The purpose of this study was to…”
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Climbing the STAIRs to SPAN the Clinical Translation Gap: Recent Advances in Multicenter Preclinical Stroke Trials by Turner, Renée J, Farr, Tracy D

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Commentary to Brain-wide continuous functional ultrasound imaging for real-time monitoring of hemodynamics during ischemic stroke by Nowak, Thaddeus S, Farr, Tracy D

“…Functional ultrasound (FUS) has emerged as a novel imaging method to reliably assess relative cerebral blood volume (rCBV) and infer perfusion, with good…”
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A pilot of the feasibility and usefulness of an aged obese model for use in stroke research by Learoyd, Annastazia E, Calmus, Ryan, Cunningham, Chelsea N, England, Tim J, Farr, Tracy D, Fone, Kevin C F, Kendall, David A, O'Sullivan, Saoirse E, Trueman, Rebecca C

“…Animal models of stroke have been criticised as having poor predictive validity, lacking risk factors prevalent in an aging population. This pilot study…”
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DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests by López-Gil, Xavier, Amat-Roldan, Iván, Tudela, Raúl, Castañé, Anna, Prats-Galino, Alberto, Planas, Anna M, Farr, Tracy D, Soria, Guadalupe

“…The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in…”
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Functional Connectivity Change in Response to Stroke Is Comparable Across Species: From Mouse to Man by Hall, Gerard R., Kaiser, Marcus, Farr, Tracy D.

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Complexities of oestrogen in stroke by Carswell, Hilary V O, Macrae, I Mhairi, Farr, Tracy D

“…Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models…”
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A Critical Re-Examination of the Intraluminal Filament MCAO Model: Impact of External Carotid Artery Transection by Trueman, Rebecca C., Harrison, David J., Dwyer, Dominic M., Dunnett, Stephen B., Hoehn, Mathias, Farr, Tracy D.

“…The intraluminal filament procedure is the most common model of middle cerebral artery occlusion (MCAO). However, consequences of subtle variations in surgical…”
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