Search Results - "FARR, C. J"

Generation of an ∼2.4 Mb Human X Centromere-Based Minichromosome by Targeted Telomere-Associated Chromosome Fragmentation in DT40 by Mills, Walter, Critcher, Ricky, Lee, Charles, Farr, Christine J.

“…A linear mammalian artificial chromosome (MAC) will require at least three types of functional element: a centromere, two telomeres and origins of replication…”
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Generation of a human X‐derived minichromosome using telomere‐associated chromosome fragmentation by Farr, C. J., Bayne, R. A., Kipling, D., Mills, W., Critcher, R., Cooke, H. J.

“…A linear mammalian artificial chromosome vector will require at least three functional elements: a centromere, two telomeres and replication origins. One route…”
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Chromosome engineering: prospects for gene therapy by GRIMES, B. R, WARBURTON, P. E, FARR, C. J

“…Recent advances in chromosome engineering and the potential for downstream applications in gene therapy were presented at the Artificial Chromosome Session of…”
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Analysis of RAS Gene Mutations in Acute Myeloid Leukemia by Polymerase Chain Reaction and Oligonucleotide Probes by Farr, Christine J., Saiki, Randall K., Erlich, Henry A., McCormick, Frank, Marshall, Christopher J.

“…In vitro DNA amplification followed by oligonucleotide dot blot analysis were used to study RAS gene mutations in acute myeloid leukemia (AML). Fifty-two…”
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Protein B61 as a new growth factor : expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression by EASTY, D. J, GUTHRIE, B. A, MAUNG, K, FARR, C. J, LINDBERG, R. A, TOSO, R. J, HERLYN, M, BENNETT, D. C

“…Epithelial cell kinase (ECK) is a receptor protein tyrosine kinase, the role of which in melanoma biology is unclear. Here we studied the role of ECK during…”
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Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML) : implications for the role of N-ras mutation in AML pathogenesis by BASHEY, A, GILL, R, FARR, C. J, CLUTTERBUCK, R, MILLAR, J. L, PRAGNELL, I. B, MARSHALL, C. J

“…The number of steps involved in the pathogenesis of acute myeloid leukemia (AML) is unclear. The initiating event would be expected to exist in all leukemic…”
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Activated ras oncogenes in human thyroid cancers by LEMOINE, N. R, MAYALL, E. S, WYLLIE, F. S, FARR, C. J, HUGHES, D, PADUA, R. A, THURSTON, V, WILLIAMS, E. D, WYNFORD-THOMAS, D

“…Human thyroid epithelial (follicular) cells give rise to two malignant tumors--"follicular" carcinomas, which metastasize almost exclusively via the…”
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Mouse Transferrin Receptor 1 Is the Cell Entry Receptor for Mouse Mammary Tumor Virus by Ross, Susan R., Schofield, Jason J., Farr, Christine J., Bucan, Maja

“…Enveloped viruses enter cells by binding to their entry receptors and fusing with the membrane at the cell surface or after trafficking through acidic…”
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Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing by Bayne, R A, Broccoli, D, Taggart, M H, Thomson, E J, Farr, C J, Cooke, H J

“…Pericentric heterochromatin and telomeres have been shown to be capable of repressing the expression of genes located in close proximity. The effect of…”
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Distribution of gamma satellite DNA on the human X and Y chromosomes suggests that it is not required for mitotic centromere function by Lee, C, Critcher, R, Zhang, J G, Mills, W, Farr, C J

“…The bulk of the DNA found at human centromeres is composed of tandemly arranged repeats, the most abundant of which is alpha satellite. Other human centromeric…”
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Generation of an similar to 2.4 Mb human X centromere-based minichromosome by targeted telomere-associated chromosome fragmentation in DT40 by Mills, W, Critcher, R, Lee, C, Farr, C J

“…A linear mammalian artificial chromosome (MAC) will require at least three types of functional element: a centromere, two telomeres and origins of replication…”
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Genetic Maps by Goodfellow, P. N., Sefton, L., Farr, C. J.

“…The same genetic principles are common to all animals, plants and microorganisms. One consequence of the generality of genetic principles is that methods…”
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Ras genes and acute myeloid leukaemia by Toksoz, D, Farr, C J, Marshall, C J

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Novel and Known Protein Tyrosine Kinases and Their Abnormal Expression in Human Melanoma by Easty, David J, Ganz, Sue E, Farr, Christine J, Lai, Cary, Herlyn, Meenhard, Bennett, Dorothy C

“…We have used the polymerase chain reaction and Northern blotting to identify protein tyrosine kinases that may play an an important role in the process of…”
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New variations on the theme by Farr, C. J, Goodfellow, P. N

“…Rsearcher Alec Jeffreys recently reported a new DNA-fingerprinting technique which extends existing methods by assaying sequence variation within minisatellite…”
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A study of ras gene mutations in colonic adenomas from familial polyposis coli patients by Farr, C J, Marshall, C J, Easty, D J, Wright, N A, Powell, S C, Paraskeva, C

“…Using an in vitro amplification step (polymerase chain reaction) followed by oligonucleotide dot blot analysis, DNA samples from 29 familial polyposis coli…”
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ras gene activation in a minor proportion of the blast population in acute myeloid leukemia by Toksoz, D, Farr, C J, Marshall, C J

“…DNAs from 22 acute myeloid leukaemia (AML) patients were screened for activated transforming genes using NIH3T3 transfection followed by assay for tumor…”
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A bovine whole-genome radiation hybrid panel and outline map by Williams, John L, Eggen, André, Ferretti, Luca, Farr, Christine J, Gautier, Mathieu, Amati, Giuseppe, Ball, Glynn, Caramorr, Tiziana, Critcher, Ricky, Costa, Sandro, Hextall, Patrick, Hills, David, Jeulin, Aurore, Kiguwa, Susanna L, Ross, Olivia, Smith, Angela L, Saunier, Katiana, Urquhart, Barbara, Waddington, Dave

“…A 3000-rad radiation hybrid panel was constructed for cattle and used to build outline RH maps for all 29 autosomes and the X and Y chromosomes. These outline…”
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Hidden Messages in Genetic Maps by Farr, Christine J., Goodfellow, Peter N.

“…Mapping information generated by the Genome Project is beginning to provide new clues to the meaning of gene order. It is clear that selection and functional…”
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Protein Tyrosine Phosphatase Genes Downregulated in Melanoma by McArdle, Linda, Rafferty, Mairin, Bergin, Orla, Easty, David J., Mælandsmo, Gunhild M., Farr, Christine J., Dervan, Peter A., O'Loughlin, Sean, Herlyn, Meenhard

“…Phospho-tyrosine levels are increased in melanoma, apparently consistent with reports of elevated protein tyrosine kinase activity. Some protein tyrosine…”
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