Search Results - "FARNDALE, R. W"

The role of collagen in thrombosis and hemostasis by Farndale, R. W., Sixma, J. J., Barnes, M. J., De Groot, P. G.

Get full text

Control of crosslinking for tailoring collagen-based scaffolds stability and mechanics by Davidenko, N., Schuster, C.F., Bax, D.V., Raynal, N., Farndale, R.W., Best, S.M., Cameron, R.E.

“…[Display omitted] We provide evidence to show that the standard reactant concentrations used in tissue engineering to cross-link collagen-based scaffolds are…”
Get full text

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation by Induruwa, I., Moroi, M., Bonna, A., Malcor, J.‐D., Howes, J.‐M., Warburton, E. A., Farndale, R. W., Jung, S. M.

“…Essentials Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin, stabilizing thrombi. GPVI‐dimers, not monomers, recognize immobilized…”
Get full text

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets by Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.

“…Essentials Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. Spatio‐temporal organization of platelet GPVI‐dimers…”
Get full text

Glycoprotein VI is a major collagen receptor for platelet activation : It recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not by KEHREL, B, WIERWILLE, S, CLEMETSON, K. J, ANDERS, O, STEINER, M, KNIGHT, C. G, FARNDALE, R. W, OKUMA, M, BARNES, M. J

“…Simple collagen-related peptides (CRPs) containing a repeat Gly-Pro-Hyp sequence are highly potent platelet agonists. Like collagen, they must exhibit tertiary…”
Get full text

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis by Sasikumar, P., AlOuda, K. S., Kaiser, W. J., Holbrook, L. M., Kriek, N., Unsworth, A. J., Bye, A. P., Sage, T., Ushioda, R., Nagata, K., Farndale, R. W., Gibbins, J. M.

“…Essentials Heat shock protein 47 (HSP47), a collagen specific chaperone is present on the platelet surface. Collagen mediated platelet function was reduced…”
Get full text

Gain‐ and loss‐of‐function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen by O'CONNOR, M. N., SMETHURST, P. A., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: By site‐directed mutagenesis of recombinant receptor fragments, we have previously identified residue lysine59 of the platelet collagen receptor…”
Get full text

Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in‐depth exon resequencing and genotyping with tag single nucleotide polymorphisms by WATKINS, N. A., O'CONNOR, M. N., RANKIN, A., JENNINGS, N., WILSON, E., HARMER, I. J., DAVIES, L., SMETHURST, P. A., DUDBRIDGE, F., FARNDALE, R. W., OUWEHAND, W. H.

“…Background: Common genetic variants of cell surface receptors contribute to differences in functional responses and disease susceptibility. We have previously…”
Get full text

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I by Howes, J.‐M., Pugh, N., Knäuper, V., Farndale, R. W.

“…Summary Background Atherothrombosis underlies acute coronary syndromes, including unstable angina and acute myocardial infarction. Within the unstable plaque,…”
Get full text

Platelet glycoprotein VI as a mediator of metastasis by FARNDALE, R. W.

Get full text

Adhesive surface determines raft composition in platelets adhered under flow by LIER, M., LEE, F., FARNDALE, R. W., GORTER, G., VERHOEF, S., OHNO‐IWASHITA, Y., AKKERMAN, J‐W. N., HEIJNEN, H. F. G.

“…Adhesion to von Willebrand factor (VWF) induces platelet spreading, whereas adhesion to collagen induces aggregation. Here we report that cholesterol‐rich…”
Get full text

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization by HEEMSKERK, J. W. M., SAKARIASSEN, K. S., ZWAGINGA, J. J., BRASS, L. F., JACKSON, S. P., FARNDALE, R. W.

Get full text

Convulxin Binding to Platelet Receptor GPVI: Competition with Collagen Related Peptides by Niedergang, F., Alcover, A., Knight, C.G., Farndale, R.W., Barnes, M.J., Francischetti, I.M.B., Bon, C., Leduc, M.

“…Convulxin (CVX), a potent platelet aggregating protein from the venom of the snake Crotalus durissus terrificus, is known to bind to the platelet collagen…”
Get full text

Nitric oxide specifically inhibits integrin‐mediated platelet adhesion and spreading on collagen by ROBERTS, W., RIBA, R., HOMER‐VANNIASINKAM, S., FARNDALE, R. W., NASEEM, K. M.

“…Background: Nitric oxide (NO) inhibits platelet adhesion to collagen, although the precise molecular mechanisms underlying this process are unclear…”
Get full text

The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens by Knight, C G, Morton, L F, Peachey, A R, Tuckwell, D S, Farndale, R W, Barnes, M J

“…We have previously assigned an integrin alpha(2)beta(1)-recognition site in collagen I to the sequence, GFOGERGVEGPOGPA (O = Hyp), corresponding to residues…”
Get full text

Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus by JONES, C. I., GARNER, S. F., ANGENENT, W., BERNARD, A., BERZUINI, C., BURNS, P., FARNDALE, R. W., HOGWOOD, J., RANKIN, A., STEPHENS, J. C., TOM, B. D., WALTON, J., DUDBRIDGE, F., OUWEHAND, W. H., GOODALL, A. H.

“…Background: Evidence suggests the wide variation in platelet response within the population is genetically controlled. Unraveling the complex relationship…”
Get full text

Synergism of hormones controlling epithelial fluid transport in an insect by MADDRELL, S. H. P, HERMAN, W. S, FARNDALE, R. W, RIEGEL, J. A

“…ABSTRACT Forskolin stimulates rapid fluid secretion by the Malpighian tubules of Rhodnius prolixus at concentrations above 5X10−6 mol l−1. In the presence of a…”
Get full text

Calcium store depletion in dimethyl BAPTA-loaded human platelets increases protein tyrosine phosphorylation in the absence of a rise in cytosolic calcium by Sargeant, P, Farndale, R W, Sage, S O

“…The endomembrane Ca(2+)-ATPase inhibitor, thapsigargin, was used to deplete the intracellular Ca2+ stores of fura-2-loaded human platelets. In control cells,…”
Get more information

Platelet receptor recognition and cross‐talk in collagen‐induced activation of platelets by FARNDALE, R. W., SLATTER, D. A., SILJANDER, P. R.‐M., JARVIS, G. E.

“…Comprehensive mapping of protein‐binding sites within human collagen III has allowed the recognition motifs for integrin α2β1 and VWF A3 domain to be…”
Get full text

Inhibition of human platelet adenylate cyclase activity by adrenaline, thrombin and collagen: analysis and reinterpretation of experimental data by Juska, A, Farndale, R W

“…Mathematical models based on the current understanding of stimulation and inhibition of adenylate cyclase (AC) activity have been developed and used to analyse…”
Get full text