Search Results - "FARMER, Stephen G"

Synthetic Serine Elastase Inhibitor Reduces Cigarette Smoke-induced Emphysema in Guinea Pigs by Wright, Joanne L, Farmer, Stephen G, Churg, Andrew

“…To test whether a serine elastase inhibitor could prevent or reduce emphysema, we exposed guinea pigs to cigarette smoke acutely, or daily for 6 months, and…”
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Peptide and non-peptide bradykinin receptor antagonists: Role in allergic airway disease by Abraham, William M., Scuri, Mario, Farmer, Stephen G.

“…Kinins are proinflammatory peptides that mediate a variety of pathophysiological responses. These actions occur through stimulation of two pharmacologically…”
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COPD in 2001: a major challenge for medicine, the pharmaceutical industry, and society by Rennard, Stephen I, Farmer, Stephen G

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Cloning, sequencing and functional expression of a guinea pig lung bradykinin B2 receptor by FARMER, S. G, POWELL, S. J, WILKINS, D. E, GRAHAM, A

“…Kinin receptors are classified as B1 and B2 based upon agonist and antagonist potencies and cloning and expression studies. Using sequences from human and rat…”
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Design and conformational analysis of several highly potent bradykinin receptor antagonists by Kyle, Donald J, Martin, Jennifer A, Farmer, Stephen G, Burch, Ronald M

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Future directions in the pharmacologic therapy of chronic obstructive pulmonary disease by Buhl, Roland, Farmer, Stephen G

“…Current therapy for chronic obstructive pulmonary disease (COPD) fails to alter its relentless progression. This remains a significant challenge and unmet…”
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Exacerbations and progression of disease in asthma and chronic obstructive pulmonary disease by Rennard, Stephen I, Farmer, Stephen G

“…Exacerbations, characterized by an increase in patients' symptoms above baseline, are characteristic of both chronic obstructive pulmonary disease (COPD) and…”
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Current and future pharmacologic therapy of exacerbations in chronic obstructive pulmonary disease and asthma by Buhl, Roland, Farmer, Stephen G

“…Exacerbations are an important cause of the morbidity and mortality associated with asthma and chronic obstructive pulmonary disease. Newer therapies include…”
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Relaxation of guinea‐pig tracheal smooth muscle to arachidonate is converted to contraction following epithelium removal by Farmer, Stephen G., Hay, Douglas W.P., Raeburn, David, Fedan, Jeffrey S.

“…1 The effect of epithelium removal on responses of guinea‐pig isolated trachealis to sodium arachidonate has been examined. 2 Arachidonate (100 μm) caused…”
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Respiratory pharmacology by Canning, Brendan J, Farmer, Stephen G

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Design and conformational analysis of several highly potent bradykinin receptor antagonists. [Erratum to document cited in CA114(15):144010y] by Kyle, Donald J, Martin, Jennifer A, Farmer, Stephen G, Burch, Ronald M

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Aminoalkynyldithianes. A new class of calcium channel blockers by Adams, Theodore C, Dupont, Andrea C, Carter, J. Paul, Kachur, James F, Guzewska, Maria E, Rzeszotarski, W. Janusz, Farmer, Stephen G, Noronha-Blob, Lalita, Kaiser, Carl

“…Several dithiane derivatives, prepared as intermediates for compounds structurally related to the therapeutically useful antimuscarinic agent oxybutynin, were…”
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Pharmacology and structure--activity relationships of the nonpeptide bradykinin receptor antagonist WIN 64338 by Sawutz, D G, Salvino, J M, Dolle, R E, Seoane, P R, Farmer, S G

“…A series of competitive, nonpeptide bradykinin receptor antagonists based on an alpha-amino acid scaffold have been developed and biologically characterized…”
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Peptide and non-peptide bradykinin receptor antagonists : Role in allergic airway disease: The Pharmacology of the Respiratory Tract by ABRAHAM, William M, SCURI, Mario, FARMER, Stephen G

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Effects of p‐chlorophenylalanine on the sensitivity of rat intestine to agonists and on intestinal 5‐hydroxytryptamine levels during Nippostrongylus brasiliensis infection by Farmer, Stephen G., Laniyonu, Adebayo A.

“…1 Infection of rats with the nematode N. brasiliensis caused non‐specific increases in maximum response of isolated intestine to acetylcholine and…”
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Biochemical and molecular pharmacology of kinin receptors by Farmer, S G, Burch, R M

“…Bradykinin (BK; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) is a potent inflammatory peptide whose generation in tissues and body fluids elicits numerous responses…”
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Cloning, sequencing and functional expression of a guinea pig lung bradykinin B 2 receptor by Farmer, Stephen G, Powell, Steve J, Wilkins, Deidre E, Graham, Alexander

“…Kinin receptors are classified as B 1 and B 2 based upon agonist and antagonist potencies and cloning and expression studies. Using sequences from human and…”
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Effects of a novel nonpeptide bradykinin B 2 receptor antagonist on intestinal and airway smooth muscle: further evidence for the tracheal B 3 receptor by Farmer, Stephen G., DeSiato, Mark A.

“…We examined the effects of phosphonium, [[4‐[[2‐[[ bis (cyclohexylamino)methylene] amino]‐3‐(2‐naphthalenyl) 1‐oxopropyl]amino]‐phenyl]‐tributyl, chloride,…”
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Effects of a novel nonpeptide bradykinin B2 receptor antagonist on intestinal and airway smooth muscle: further evidence for the tracheal B3 receptor by Farmer, Stephen G., DeSiato, Mark A.

“…1 We examined the effects of phosphonium, [[4‐[[2‐[[bis(cyclohexylamino)methylene] amino]‐3‐(2‐naphthalenyl) 1‐oxopropyl]amino]‐phenyl]‐tributyl, chloride,…”
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N-(Fluorenyl-9-Methoxycarbonyl) Amino Acids, a Class of Antiinflammatory Agents With a different Mechanism of Action by Burch, Ronald M., Weitzberg, Moshe, Blok, Natalie, Muhlhauser, Richard, Martin, David, Farmer, Stephen G., Bator, Jenny M., Connor, Jane R., Ko, Chiew, Kuhn, Wendy, McMillan, Barbara A., Raynor, Maureen, Shearer, Barry G., Tiffany, Carol, Wilkins, Deidre E.

“…Several members of a series of N-(fluorenyl-9-methoxycarbonyl) amino acids were found to possess a broad spectrum of antiinflammatory activity. The compounds…”
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