Search Results - "FARKAS, Attila E"

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair by Cruz-Acuña, Ricardo, Quirós, Miguel, Farkas, Attila E., Dedhia, Priya H., Huang, Sha, Siuda, Dorothée, García-Hernández, Vicky, Miller, Alyssa J., Spence, Jason R., Nusrat, Asma, García, Andrés J.

“…In vitro differentiation of human intestinal organoids (HIOs) from pluripotent stem cells is an unparalleled system for creating complex, multicellular…”
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The Blood-Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders by Costea, Laura, Mészáros, Ádám, Bauer, Hannelore, Bauer, Hans-Christian, Traweger, Andreas, Wilhelm, Imola, Farkas, Attila E, Krizbai, István A

“…With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this decline can become a major impediment to normal daily life. Recent…”
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Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins by Capaldo, Christopher T, Farkas, Attila E, Hilgarth, Roland S, Krug, Susanne M, Wolf, Mattie F, Benedik, Jeremy K, Fromm, Michael, Koval, Michael, Parkos, Charles, Nusrat, Asma

“…Tight junctions (TJs) are dynamic, multiprotein intercellular adhesive contacts that provide a vital barrier function in epithelial tissues. TJs are remodeled…”
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Senolysis potentiates endothelial progenitor cell adhesion to and integration into the brain vasculature by Lam, Tri Duc, Tóth, István, Hermenean, Anca, Wilhelm, Imola, Kieda, Claudine, Krizbai, István, Farkas, Attila E

“…Background One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus,…”
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Transmigration of melanoma cells through the blood-brain barrier: role of endothelial tight junctions and melanoma-released serine proteases by Fazakas, Csilla, Wilhelm, Imola, Nagyoszi, Péter, Farkas, Attila E, Haskó, János, Molnár, Judit, Bauer, Hannelore, Bauer, Hans-Christian, Ayaydin, Ferhan, Dung, Ngo Thi Khue, Siklós, László, Krizbai, István A

“…Malignant melanoma represents the third common cause of brain metastasis, having the highest propensity to metastasize to the brain of all primary neoplasms in…”
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Pericyte‐secreted IGF2 promotes breast cancer brain metastasis formation by Molnár, Kinga, Mészáros, Ádám, Fazakas, Csilla, Kozma, Mihály, Győri, Fanni, Reisz, Zita, Tiszlavicz, László, Farkas, Attila E., Nyúl‐Tóth, Ádám, Haskó, János, Krizbai, István A., Wilhelm, Imola

“…Brain metastases are life‐threatening complications of triple‐negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary…”
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Expression and regulation of toll-like receptors in cerebral endothelial cells by Nagyőszi, Péter, Wilhelm, Imola, Farkas, Attila E., Fazakas, Csilla, Dung, Ngo Thi Khue, Haskó, János, Krizbai, István A.

“…Cerebral endothelial cells – the principal components of the blood–brain barrier (BBB) – fulfill several important functions in the central nervous system…”
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Pharmacological Targeting of the Inflamed Intestinal Barrier by Farkas, Attila E, Nusrat, Asma

“…The intestinal epithelium serves as an important barrier between luminal contents and underlying tissue compartments. Barrier properties are established and…”
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Regulation of epithelial proliferation by tight junction proteins by Farkas, Attila E., Capaldo, Christopher T., Nusrat, Asma

“…The epithelial tight junction (TJ) is the apical‐most intercellular junction and serves as a gatekeeper for the paracellular pathway by permitting regulated…”
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Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization by Menyhárt, Ákos, Farkas, Attila E., Varga, Dániel P., Frank, Rita, Tóth, Réka, Bálint, Armand R., Makra, Péter, Dreier, Jens P., Bari, Ferenc, Krizbai, István A., Farkas, Eszter

“…Recurrent spreading depolarizations occur in the cerebral cortex from minutes up to weeks following acute brain injury. Clinical evidence suggests that the…”
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Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals by Kozma, Mihály, Mészáros, Ádám, Nyúl-Tóth, Ádám, Molnár, Kinga, Costea, Laura, Hernádi, Zsófia, Fazakas, Csilla, Farkas, Attila E., Wilhelm, Imola, Krizbai, István A.

“…By upregulation of cell adhesion molecules and secretion of proinflammatory cytokines, cells of the neurovascular unit, including pericytes and endothelial…”
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Astrocyte Ca2+ Waves and Subsequent Non-Synchronized Ca2+ Oscillations Coincide with Arteriole Diameter Changes in Response to Spreading Depolarization by Tóth, Réka, Farkas, Attila E., Krizbai, István A., Makra, Péter, Bari, Ferenc, Farkas, Eszter, Menyhárt, Ákos

“…Spreading depolarization (SD) is a wave of mass depolarization that causes profound perfusion changes in acute cerebrovascular diseases. Although the astrocyte…”
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Pharmaceutical Targeting of the Brain by Krizbai, István A, Nyúl-Tóth, Ádám, Bauer, Hans-Christian, Farkas, Attila E, Traweger, Andreas, Haskó, János, Bauer, Hannelore, Wilhelm, Imola

“…Besides being indispensable for the protection and nutrition of the central nervous system (CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells…”
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“Endothelial Antibody Factory” at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases by Thinard, Reynald, Farkas, Attila E., Halasa, Marta, Chevalier, Melanie, Brodaczewska, Klaudia, Majewska, Aleksandra, Zdanowski, Robert, Paprocka, Maria, Rossowska, Joanna, Duc, Lam Tri, Greferath, Ruth, Krizbai, Istvan, Van Leuven, Fred, Kieda, Claudine, Nicolau, Claude

“…The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering…”
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Response of the neurovascular unit to brain metastatic breast cancer cells by Haskó, János, Fazakas, Csilla, Molnár, Kinga, Mészáros, Ádám, Patai, Roland, Szabó, Gábor, Erdélyi, Ferenc, Nyúl-Tóth, Ádám, Győri, Fanni, Kozma, Mihály, Farkas, Attila E, Krizbai, István A, Wilhelm, Imola

“…Therapeutic resistance of cerebral secondary tumours largely depends on unique aspects linked to the neurovascular unit, especially cerebral endothelial cells…”
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Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharide-induced damages by Veszelka, Szilvia, Pásztói, Mária, Farkas, Attila E., Krizbai, István, Dung, Ngo Thi Khue, Niwa, Masami, Ábrahám, Csongor S., Deli, Mária A.

“…Peripheral inflammation can aggravate local brain inflammation and neuronal death. The blood–brain barrier (BBB) is a key player in the event. On a relevant in…”
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Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography by Nyúl-Tóth, Ádám, Tarantini, Stefano, DelFavero, Jordan, Yan, Feng, Balasubramanian, Priya, Yabluchanskiy, Andriy, Ahire, Chetan, Kiss, Tamas, Csipo, Tamas, Lipecz, Agnes, Farkas, Attila E, Wilhelm, Imola, Krizbai, István A, Tang, Qinggong, Csiszar, Anna, Ungvari, Zoltan

“…Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction contribute importantly to the pathogenesis of both vascular cognitive…”
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Role of pattern recognition receptors of the neurovascular unit in inflamm-aging by Wilhelm, Imola, Nyúl-Tóth, Ádám, Kozma, Mihály, Farkas, Attila E, Krizbai, István A

“…Aging is associated with chronic inflammation partly mediated by increased levels of damage-associated molecular patterns, which activate pattern recognition…”
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N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain by Szabó, Írisz, Varga, Viktória É., Dvorácskó, Szabolcs, Farkas, Attila E., Körmöczi, Tímea, Berkecz, Róbert, Kecskés, Szilvia, Menyhárt, Ákos, Frank, Rita, Hantosi, Dóra, Cozzi, Nicholas V., Frecska, Ede, Tömböly, Csaba, Krizbai, István A., Bari, Ferenc, Farkas, Eszter

“…Dimethyltryptamine (DMT), an endogenous ligand of sigma-1 receptors (Sig-1Rs), acts against systemic hypoxia, but whether DMT may prevent cerebral ischemic…”
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Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci by Menyhárt, Ákos, Frank, Rita, Farkas, Attila E, Süle, Zoltán, Varga, Viktória É, Nyúl-Tóth, Ádám, Meiller, Anne, Ivánkovits-Kiss, Orsolya, Lemale, Coline L, Szabó, Írisz, Tóth, Réka, Zölei-Szénási, Dániel, Woitzik, Johannes, Marinesco, Stephane, Krizbai, István A, Bari, Ferenc, Dreier, Jens P, Farkas, Eszter

“…Spreading depolarizations (SDs) indicate injury progression and predict worse clinical outcome in acute brain injury. We demonstrate in rodents that acute…”
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