Search Results - "FARINA, Marcelo"

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay by Farina, Marcelo, Aschner, Michael

“…Methylmercury (MeHg) is a toxic chemical compound naturally produced mainly in the aquatic environment through the methylation of inorganic mercury catalyzed…”
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The Nrf2 Pathway in Ischemic Stroke: A Review by Farina, Marcelo, Vieira, Leonardo Eugênio, Buttari, Brigitta, Profumo, Elisabetta, Saso, Luciano

“…Ischemic stroke, characterized by the sudden loss of blood flow in specific area(s) of the brain, is the leading cause of permanent disability and is among the…”
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Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury by Farina, Marcelo, Avila, Daiana Silva, da Rocha, João Batista Teixeira, Aschner, Michael

“…► Oxidative stress (OS), particularly in mitochondria, is a common feature of iron (Fe), Mn and Hg toxicity. ► The primary molecular targets triggering of OS…”
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LPS-Activated Microglial Cell-Derived Conditioned Medium Protects HT22 Neuronal Cells against Glutamate-Induced Ferroptosis by Jacques, Mauricio Tavares, Saso, Luciano, Farina, Marcelo

“…Neuron-glia interactions are essential for the central nervous system's homeostasis. Microglial cells are one of the key support cells in the brain that…”
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Developmental Politics, Urban and Agrarian Reforms, and Eminent Domain Laws in ‘Era Vargas’ (1930-1964): Some Sociolegal Historical Considerations on the Concept and Its Reflections on Nowadays Brazilian Land Law by Pezzolo Farina, Marcelo

“…The 'Era Vargas' brought a shift in Brazilian economic politics, using a developmentalist approach. Named after President Getúlio Vargas, who ruled as a…”
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Effects of Sublethal Doses of Imidacloprid on Young Adult Honeybee Behaviour by Mengoni Goñalons, Carolina, Farina, Walter Marcelo

“…Imidacloprid (IMI), a neonicotinoid used for its high selective toxicity to insects, is one of the most commonly used pesticides. However, its effect on…”
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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19 by Liu, Hengrui, Iketani, Sho, Zask, Arie, Khanizeman, Nisha, Bednarova, Eva, Forouhar, Farhad, Fowler, Brandon, Hong, Seo Jung, Mohri, Hiroshi, Nair, Manoj S., Huang, Yaoxing, Tay, Nicholas E. S., Lee, Sumin, Karan, Charles, Resnick, Samuel J., Quinn, Colette, Li, Wenjing, Shion, Henry, Xia, Xin, Daniels, Jacob D., Bartolo-Cruz, Michelle, Farina, Marcelo, Rajbhandari, Presha, Jurtschenko, Christopher, Lauber, Matthew A., McDonald, Thomas, Stokes, Michael E., Hurst, Brett L., Rovis, Tomislav, Chavez, Alejandro, Ho, David D., Stockwell, Brent R.

“…The SARS-CoV-2 3CL protease is a critical drug target for small molecule COVID-19 therapy, given its likely druggability and essentiality in the viral…”
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Biomarkers of mercury toxicity: Past, present, and future trends by Branco, Vasco, Caito, Sam, Farina, Marcelo, Teixeira da Rocha, João, Aschner, Michael, Carvalho, Cristina

“…Mercury (Hg) toxicity continues to represent a global health concern. Given that human populations are mostly exposed to low chronic levels of mercurial…”
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Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies by Farina, Marcelo, Rocha, João B.T., Aschner, Michael

“…Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of…”
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Ferroptosis as a mechanism of non-ferrous metal toxicity by Aschner, Michael, Skalny, Anatoly V., Martins, Airton C., Sinitskii, Anton I., Farina, Marcelo, Lu, Rongzhu, Barbosa, Fernando, Gluhcheva, Yordanka G., Santamaria, Abel, Tinkov, Alexey A.

“…Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple pathologies. Given that the toxicity elicited by some metals is…”
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Methylmercury and brain development: A review of recent literature by Antunes dos Santos, Alessandra, Appel Hort, Mariana, Culbreth, Megan, López-Granero, Caridad, Farina, Marcelo, Rocha, Joao B.T., Aschner, Michael

“…Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in humans. The central nervous system (CNS) is the primary target…”
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Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines by Estravis Barcala, María Cecilia, Palottini, Florencia, Farina, Walter Marcelo

“…Insect pollination is issential for hybrid seed production systems, among which, introduced and native bees are the primary pollinating agents transferring…”
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Paraquat and Maneb Exposure Alters Rat Neural Stem Cell Proliferation by Inducing Oxidative Stress: New Insights on Pesticide-Induced Neurodevelopmental Toxicity by Colle, Dirleise, Farina, Marcelo, Ceccatelli, Sandra, Raciti, Marilena

“…Pesticide exposure has been linked to the pathogenesis of neurodevelopmental and neurodegenerative disorders including autism spectrum disorders, attention…”
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The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells by Galant, Letícia Selinger, Rafique, Jamal, Braga, Antônio Luiz, Braga, Felipe Camargo, Saba, Sumbal, Radi, Rafael, da Rocha, João Batista Teixeira, Santi, Claudio, Monsalve, Maria, Farina, Marcelo, de Bem, Andreza Fabro

“…Most pharmacological studies concerning the beneficial effects of organoselenium compounds have focused on their ability to mimic glutathione peroxidase (GPx)…”
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Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress by Moretti, Morgana, Colla, André, de Oliveira Balen, Grasiela, dos Santos, Danúbia Bonfanti, Budni, Josiane, de Freitas, Andiara Espíndola, Farina, Marcelo, Severo Rodrigues, Ana Lúcia

“…Abstract Reactive oxygen species (ROS) have been shown to play a role in the pathophysiology of depression. Taking into account that experimental chronic…”
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Probucol Protects Neuronal Cells Against Peroxide-Induced Damage and Directly Activates Glutathione Peroxidase-1 by Santos, Danúbia B., Colle, Dirleise, Moreira, Eduardo L. G., Santos, Alessandra A., Hort, Mariana A., Santos, Karin, Oses, Jean P., Razzera, Guilherme, Farina, Marcelo

“…Experimental evidence has shown that probucol, a hypocholesterolemic agent, is also able to increase glutathione peroxidase (GPx) activity. However, there is a…”
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Post-translational modifications in MeHg-induced neurotoxicity by Ke, Tao, Gonçalves, Filipe Marques, Gonçalves, Cinara Ludvig, dos Santos, Alessandra Antunes, Rocha, João B.T., Farina, Marcelo, Skalny, Anatoly, Tsatsakis, Aristidis, Bowman, Aaron B., Aschner, Michael

“…Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been…”
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Methylmercury-Induced Neurotoxicity: Focus on Pro-oxidative Events and Related Consequences by Farina, Marcelo, Aschner, Michael

“…Methylmercury (MeHg) is a highly neurotoxic environmental pollutant. Even though molecular mechanisms mediating MeHg toxicity are not completely understood,…”
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Manganese overexposure results in ferroptosis through the HIF-1α/p53/SLC7A11 pathway in ICR mouse brain and PC12 cells by Chen, Jian, Tao, Zehua, Zhang, Xinyu, Hu, Jing, Wang, Suhua, Xing, Guangwei, Ngeng, Ngwa Adeline, Malik, Abdul, Appiah-Kubi, Kwaku, Farina, Marcelo, Skalny, Anatoly V., Tinkov, Alexey, Aschner, Michael, Yang, Bobo, Lu, Rongzhu

“…Manganese (Mn) overexposure has been associated with the development of neurological damage reminiscent of Parkinson's disease, while the underlying mechanisms…”
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Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells by dos Santos, Alessandra Antunes, López-Granero, Caridad, Farina, Marcelo, Rocha, João B.T., Bowman, Aaron B., Aschner, Michael

“…Methylmercury is a toxic environmental contaminant that elicits significant toxicity in humans. The central nervous system is the primary target of toxicity,…”
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