Search Results - "FARINA, Cinthia"

Publicly available ex vivo transcriptomics datasets to explore CNS physiology and neurodegeneration: state of the art and perspectives by Abdullatef, Sandra, Farina, Cinthia

“…The central nervous system (CNS) is characterized by an intricate composition of diverse cell types, including neurons and glia cells (astrocytes,…”
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Role of copper in central nervous system physiology and pathology by Locatelli, Martina, Farina, Cinthia

“…Copper is a transition metal and an essential element for the organism, as alterations in its homeostasis leading to metal accumulation or deficiency have…”
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Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation by Grassivaro, Francesca, Menon, Ramesh, Acquaviva, Massimo, Ottoboni, Linda, Ruffini, Francesca, Bergamaschi, Andrea, Muzio, Luca, Farina, Cinthia, Martino, Gianvito

“…Differently from other myeloid cells, microglia derive exclusively from precursors originating within the yolk sac and migrate to the CNS under development,…”
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Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide by Colombo, Emanuela, Di Dario, Marco, Capitolo, Eleonora, Chaabane, Linda, Newcombe, Jia, Martino, Gianvito, Farina, Cinthia

“…Objective Although astrocytes participate in glial scar formation and tissue repair, dysregulation of the NFκB pathway and of nitric oxide (NO) production in…”
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Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration by Colombo, Emanuela, Bassani, Claudia, De Angelis, Anthea, Ruffini, Francesca, Ottoboni, Linda, Comi, Giancarlo, Martino, Gianvito, Farina, Cinthia

“…Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system (CNS) with heterogeneous pathophysiology. In its progressive…”
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Three Decades of Interferon-β in Multiple Sclerosis: Can We Repurpose This Information for the Management of SARS-CoV2 Infection? by Severa, Martina, Farina, Cinthia, Salvetti, Marco, Coccia, Eliana Marina

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Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes by Bacigaluppi, Marco, Russo, Gianluca Luigi, Peruzzotti-Jametti, Luca, Rossi, Silvia, Sandrone, Stefano, Butti, Erica, De Ceglia, Roberta, Bergamaschi, Andrea, Motta, Caterina, Gallizioli, Mattia, Studer, Valeria, Colombo, Emanuela, Farina, Cinthia, Comi, Giancarlo, Politi, Letterio Salvatore, Muzio, Luca, Villani, Claudia, Invernizzi, Roberto William, Hermann, Dirk Matthias, Centonze, Diego, Martino, Gianvito

“…Ischemic stroke is the leading cause of disability, but effective therapies are currently widely lacking. Recovery from stroke is very much dependent on the…”
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Astrocyte TrkB promotes brain injury and edema formation in ischemic stroke by Colombo, Emanuela, Bacigaluppi, Marco, Bartoccetti, Michela, Triolo, Daniela, Bassani, Claudia, Bergamaschi, Andrea, Descamps, Hélène C., Gullotta, Giorgia Serena, Henley, Maria, Piccoli, Marco, Anastasia, Luigi, Pitt, David, Newcombe, Jia, Martino, Gianvito, Farina, Cinthia

“…Following ischemic stroke astrocytes undergo rapid molecular and functional changes that may accentuate tissue damage. In this study we identified the…”
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Editorial: A Microbial View of Central Nervous System Disorders: Interplay Between Microorganisms, Neuroinflammation and Behaviour by Cossu, Davide, Watson, Robert O, Farina, Cinthia

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The phenotypic convergence between microglia and peripheral macrophages during development and neuroinflammation paves the way for new therapeutic perspectives by Grassivaro, Francesca, Martino, Gianvito, Farina, Cinthia

“…Microglia, the tissue resident macrophages of the brain, are increasingly recognized as key players for central nervous system development and homeostasis…”
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Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective by Olude, Matthew Ayokunle, Mouihate, Abdeslam, Mustapha, Oluwaseun Ahmed, Farina, Cinthia, Quintana, Francisco Javier, Olopade, James Olukayode

“…Africa is laden with a youthful population, vast mineral resources and rich fauna. However, decades of unfortunate historical, sociocultural and leadership…”
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Shared molecular and functional frameworks among five complex human disorders: a comparative study on interactomes linked to susceptibility genes by Menon, Ramesh, Farina, Cinthia

“…Genome-wide association studies (gwas) are invaluable in revealing the common variants predisposing to complex human diseases. Yet, until now, the large…”
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Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration by Colombo, Emanuela, Cordiglieri, Chiara, Melli, Giorgia, Newcombe, Jia, Krumbholz, Markus, Parada, Luis F, Medico, Enzo, Hohlfeld, Reinhard, Meinl, Edgar, Farina, Cinthia

“…Neurotrophin growth factors support neuronal survival and function. In this study, we show that the expression of the neurotrophin receptor TrkB is induced on…”
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Activated macrophages release microvesicles containing polarized M1 or M2 mRNAs by Garzetti, Livia, Menon, Ramesh, Finardi, Annamaria, Bergami, Alessandra, Sica, Antonio, Martino, Gianvito, Comi, Giancarlo, Verderio, Claudia, Farina, Cinthia, Furlan, Roberto

“…Microvesicles released by activated macrophages, and detected in biological fluids, may constitute a valuable biomarker to identify myeloid cell activation…”
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JAB1 deletion in oligodendrocytes causes senescence-induced inflammation and neurodegeneration in mice by Rivellini, Cristina, Porrello, Emanuela, Dina, Giorgia, Mrakic-Sposta, Simona, Vezzoli, Alessandra, Bacigaluppi, Marco, Gullotta, Giorgia Serena, Chaabane, Linda, Leocani, Letizia, Marenna, Silvia, Colombo, Emanuela, Farina, Cinthia, Newcombe, Jia, Nave, Klaus-Armin, Pardi, Ruggero, Quattrini, Angelo, Previtali, Stefano C

“…Oligodendrocytes are the primary target of demyelinating disorders, and progressive neurodegenerative changes may evolve in the CNS. DNA damage and oxidative…”
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Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway by Colombo, Federico, Bastoni, Mattia, Nigro, Annamaria, Podini, Paola, Finardi, Annamaria, Casella, Giacomo, Ramesh, Menon, Farina, Cinthia, Verderio, Claudia, Furlan, Roberto

“…Microvesicles (MVs) are membrane particles of 200-500 nm released by all cell types constitutively. MVs of myeloid origin are found increased in the…”
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Circulating MAIT cells in multiple sclerosis and amyotrophic lateral sclerosis by De Federicis, Davide, Bassani, Claudia, Chiarelli, Rosaria Rita, Montini, Federico, Giordano, Antonino, Esposito, Federica, Riva, Nilo, Quattrini, Angelo, Martinelli, Vittorio, Filippi, Massimo, Farina, Cinthia

“…Neurological disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), may be associated with alterations in blood cell composition…”
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iAstrocytes do not restrain T cell proliferation in vitro by Colombo, Emanuela, De Angelis, Anthea, Bassani, Claudia, Ruffini, Francesca, Ottoboni, Linda, Garzetti, Livia, Finardi, Annamaria, Martino, Gianvito, Furlan, Roberto, Farina, Cinthia

“…The cross-talk between T cells and astrocytes occurring under physiological and, even more, neuroinflammatory conditions may profoundly impact the generation…”
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Laquinimod Modulates Human Astrocyte Function and Dampens Astrocyte-Induced Neurotoxicity during Inflammation by Colombo, Emanuela, Pascente, Rosaria, Triolo, Daniela, Bassani, Claudia, De Angelis, Anthea, Ruffini, Francesca, Ottoboni, Linda, Comi, Giancarlo, Martino, Gianvito, Farina, Cinthia

“…Astrocytes greatly participate to inflammatory and neurotoxic reactions occurring in neurodegenerative diseases and are valuable pharmacological targets to…”
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Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment by Krumbholz, Markus, Theil, Diethilde, Cepok, Sabine, Hemmer, Bernhard, Kivisäkk, Pia, Ransohoff, Richard M., Hofbauer, Monika, Farina, Cinthia, Derfuss, Tobias, Hartle, Caroline, Newcombe, Jia, Hohlfeld, Reinhard, Meinl, Edgar

“…Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers significant therapeutic potential. This study focused on the…”
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