Search Results - "FARESE, R. V"

Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors by Sajan, M. P., Farese, R. V.

“…Aims/hypothesis We examined the role of protein kinase C-ι (PKC-ι) in mediating alterations in the abundance of enzymes in hepatocytes of type 2 diabetic…”
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Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis by Olson, D.K., Fröhlich, F., Farese, R.V., Walther, T.C.

“…Sphingolipids are important structural membrane components of eukaryotic cells, and potent signaling molecules. As such, their levels must be maintained to…”
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Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members by Cases, Sylvaine, Stone, Scot J., Zhou, Ping, Yen, Eric, Tow, Bryan, Lardizabal, Kathryn D., Voelker, Toni, Farese, Robert V.

“…Studies involving the cloning and disruption of the gene for acyl-CoA:diacylglycerol acyltransferase (DGAT) have shown that alternative mechanisms exist for…”
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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat by Farese, Robert V, Smith, Steven J, Cases, Sylvaine, Jensen, Dalan R, Chen, Hubert C, Sande, Eric, Tow, Bryan, Sanan, David A, Raber, Jacob, Eckel, Robert H

“…Triglycerides (or triacylglycerols) represent the major form of stored energy in eukaryotes. Triglyceride synthesis has been assumed to occur primarily through…”
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AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC by Sajan, M P, Bandyopadhyay, G, Miura, A, Standaert, M L, Nimal, S, Longnus, S L, Van Obberghen, E, Hainault, I, Foufelle, F, Kahn, R, Braun, U, Leitges, M, Farese, R V

“…Activators of 5'-AMP-activated protein kinase (AMPK) 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), metformin, and exercise activate atypical…”
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A dual thrombin receptor system for platelet activation by Coughlin, Shaun R, Kahn, Mark L, Zheng, Yao-Wu, Huang, Wei, Bigornia, Violeta, Zeng, Dewan, Moff, Stephen, Farese, Robert V, Tam, Carmen

“…Platelet-dependent arterial thrombosis triggers most heart attacks and strokes. Because the coagulation protease thrombin is the most potent activator of…”
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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice by Boring, L, Gosling, J, Chensue, S W, Kunkel, S L, Farese, Jr, R V, Broxmeyer, H E, Charo, I F

“…Monocyte chemoattractant protein-1 (MCP-1) is a potent agonist for mononuclear leukocytes and has been implicated in the pathogenesis of atherosclerosis and…”
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Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance by Sajan, M. P, Standaert, M. L, Rivas, J, Miura, A, Kanoh, Y, Soto, J, Taniguchi, C. M, Kahn, C. R, Farese, R. V

“…Aims/hypothesis Previous findings in rodents used as a model of diabetes suggest that insulin activation of atypical protein kinase C (aPKC) is impaired in…”
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Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice by Farese, Robert V, Buhman, Kimberly K, Accad, Michel, Novak, Sabine, Choi, Rebekah S, Wong, Jinny S, Hamilton, Robert L, Turley, Stephen

“…The importance of cholesterol ester synthesis by acyl CoA:cholesterol acyltransferase (ACAT) enzymes in intestinal and hepatic cholesterol metabolism has been…”
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Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis by Cases, S. (University of California, San Francisco, CA.), Smith, S.J, Zheng, Y.W, Myers, H.M, Lear, S.R, Sande, E, Novak, S, Collins, C, Welch, C.B, Lusis, A.J

“…Triacylglycerols are quantitatively the most important storage form of energy for eukaryotic cells. Acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20)…”
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Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1 by Huang, X. Z., Wu, J. F., Ferrando, R., Lee, J. H., Wang, Y. L., Farese, R. V., Sheppard, D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages by Fazio, S, Major, A S, Swift, L L, Gleaves, L A, Accad, M, Linton, M F, Farese, Jr, R V

“…During atherogenesis, circulating macrophages migrate into the subendothelial space, internalize cholesterol-rich lipoproteins, and become foam cells by…”
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Role of the thrombin receptor in development and evidence for a second receptor by Connolly, Andrew J, Ishihara, Hiroaki, Kahn, Mark L, Farese, Robert V, Coughlin, Shaun R

“…Thrombin, a coagulation protease generated at sites of vascular injury, activates platelets, endothelial cells, leukocytes and mesenchymal cells. A…”
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Increased Atherosclerosis in Hyperlipidemic Mice Deficient in α-Tocopherol Transfer Protein and Vitamin E by Terasawa, Y, Ladha, Z, Leonard, S W, Morrow, J D, Newland, D, Sanan, D, Packer, L, Traber, M G, Farese, Jr, R V

“…Although lipid peroxidation in the subendothelial space has been hypothesized to play a central role in atherogenesis, the role of vitamin E in preventing…”
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Introduction of Human Apolipoprotein E4 "Domain Interaction" into Mouse Apolipoprotein E by Raffaï, Robert L., Dong, Li-Ming, Farese, Robert V., Weisgraber, Karl H.

“…Human apolipoprotein E4 (apoE4) binds preferentially to lower density lipoproteins, including very low density lipoproteins, and is associated with increased…”
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Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO₄)₃ in muscle of diabetic subjects by Luna, V, Casauban, L, Sajan, M. P, Gomez-Daspet, J, Powe, J. L, Miura, A, Rivas, J, Standaert, M. L, Farese, R. V

“…Aims/hypothesis Metformin is widely used for treating type 2 diabetes mellitus, but its actions are poorly understood. In addition to diminishing hepatic…”
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Cholesterol metabolism and embryogenesis by Farese, Jr, Robert V, Herz, Joachim

“…Although cholesterol has long been known to be an essential component of cell membranes in vertebrate organisms, recent studies have suggested that cholesterol…”
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Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes by Farese, R.V. Jr. (University of California, San Francisco, CA.), Ruland, S.L, Flynn, L.M, Stokowski, R.P, Young, S.G

“…Apolipoprotein B is synthesized by the intestine and the liver in mammals, where it serves as the main structural component in the formation of chylomicrons…”
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Familial hypobetalipoproteinemia by Linton, MF, Farese, RV, Young, SG

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Atypical protein kinase C in insulin action and insulin resistance by Farese, R V, Sajan, M P, Standaert, M L

“…It now seems clear that aPKC (atypical protein kinase C) isoforms are required for insulin-stimulated glucose transport in muscle and adipocytes. Moreover,…”
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