Search Results - "FARACI, W. S"

2‐Amino‐4‐methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo by Faraci, W. Stephen, Nagel, Arthur A., Verdries, Kimberly A., Vincent, Lawrence A., Xu, Hong, Nichols, Lois E., Labasi, Jeffrey M., Salter, Eben D., Pettipher, E. Roy

“…1 The ability of 2‐amino‐4‐methylpyridine to inhibit the catalytic activity of the inducible NO synthase (NOS II) enzyme was characterized in vitro and in…”
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Posttranslational Amino Acid Epimerization: Enzyme-Catalyzed Isomerization of Amino Acid Residues in Peptide Chains by Heck, Steven D., Faraci, W. Stephen, Kelbaugh, Paul R., Saccomano, Nicholas A., Thadeio, Peter F., Volkmann, Robert A.

“…Since ribosomally mediated protein biosynthesis is confined to the L-amino acid pool, the presence of D-amino acids in peptides was considered for many years…”
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Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal by Bakker, A V, Jung, S, Spencer, R W, Vinick, F J, Faraci, W S

“…Prolyl endopeptidase is a serine proteinase that specifically cleaves peptides on the carboxy side of proline residues. Wilk & Orlowski [(1983) J. Neurochem…”
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Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product by Rusnak, Frank, Faraci, W. Stephen, Walsh, Christopher T

“…The gene coding for the enzyme 2,3-dihydroxybenzoate-AMP ligase (2,3DHB-AMP ligase), responsible for activating 2,3-dihydroxybenzoic acid in the biosynthesis…”
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A new class of selective and potent inhibitors of neuronal nitric oxide synthase by Lowe, John A., Qian, Weimin, Volkmann, Robert A., Heck, Steven, Nowakowski, Jolanta, Nelson, Robert, Nolan, Charles, Liston, Dane, Ward, Karen, Zorn, Stevin, Johnson, Celeste, Vanase, Michelle, Faraci, W. Stephen, Verdries, Kimberly A., Baxter, James, Doran, Shawn, Sanders, Martin, Ashton, Mike, Whittle, Peter, Stefaniak, Mark

“…The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this…”
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Synthesis and Oral Efficacy of a 4-(Butylethylamino)pyrrolo[2,3-d]pyrimidine:  A Centrally Active Corticotropin-Releasing Factor1 Receptor Antagonist by Chen, Yuhpyng L, Mansbach, Robert S, Winter, Steven M, Brooks, Elizabeth, Collins, Judith, Corman, Michael L, Dunaiskis, Audrey R, Faraci, W. Stephen, Gallaschun, Randall J, Schmidt, Anne, Schulz, David W

“…The syntheses of a centrally active nonpeptide CRF1 receptor antagonist 2,…”
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Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation by FARACI, W. S, ZORN, S. H, BAKKER, A. V, JACKSON, E, PRATT, K

“…Despite limiting side-effects, lithium is the drug of choice for the treatment of bipolar depression. Its action may be due, in part, to its ability to dampen…”
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Mechanism of inhibition of the PC1 .beta.-lactamase of Staphylococcus aureus by cephalosporins: importance of the 3'-leaving group by Faraci, W. Stephen, Pratt, Rex F

“…The hydrolysis of cephalosporins containing good leaving groups at the 3'-position [those used in this study were the chromogenic cephalosporin PADAC…”
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Mechanism of inhibition of RTEM-2β-lactamase by cephamycins: relative importance of the 7α-methoxy group and the 3' leaving group by FARACI, W. S, PRATT, R. F

“…Cefoxitin is a poor substrate of many beta-lactamases, including the RTEM-2 enzyme. Fisher and co-workers [Fisher, J., Belasco, J. G., Khosla, S., & Knowles,…”
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Interactions of cephalosporins with the Streptomyces R61 DD-transpeptidase/carboxypeptidase. Influence of the 3'-substituent by Faraci, W S, Pratt, R F

“…The influence and fate of the 3'-substituent of a series of cephalosporins on their interaction with the DD-transpeptidase/carboxypeptidase of Streptomyces R61…”
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Novel inhibitors of prolyl endopeptidase: effects of stereochemistry by Kolosko, N, Bakker, A V, Faraci, W S, Nagel, A A

“…Prolyl endopeptidase is a serine protease that specifically cleaves peptides on the carboxyl side of proline residues. We have show that racemic…”
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Synthesis, sar and pharmacology of CP-293,019 : A potent, selective dopamine D4 receptor antagonist by SANNER, M. A, CHAPPIE, T. A, MAJCHRZAK, M. J, FARACI, W. S, COLLINS, J. L, DUIGNAN, D. B, DI PRETE, C. C, LEE, J. S, TROZZI, A, DUNAISKIS, A. R, FLIRI, A. F, DESAI, K. A, ZORN, S. H, JACKSON, E. R, JOHNSON, C. G, MORRONE, J. M, SEYMOUR, P. A

“…A series of novel, potent and selective pyrido[1,2-a]pyrazine dopamine D4 receptor antagonists are reported including CP-293,019 (D4 Ki = 3.4 nM, D2 Ki > 3,310…”
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Inhibition of Helicobacter pylori Urease by Phenyl Phosphorodiamidates: Mechanism of Action by Faraci, W.Stephen, Yang, Bingwei V., O'Rourke, Dawn, Spencer, Robin W.

“…Helicobacter pylori urease is a nickel-containing enzyme that hydrolyzes urea to bicarbonate and ammonia. Andrews et al. ( J. Am. Chem. Soc. 1986, 108, 7124) 1…”
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The discovery of potent and selective dopamine D4 receptor antagonists by Faraci, W Stephen, Zorn, Stevin H, Sanner, Mark A, Fliri, Anton

“…The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychoti drug clozapine with high…”
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Mechanism of inactivation of alanine racemase by .beta.,.beta.,.beta.-trifluoroalanine by Faraci, W. Stephen, Walsh, Christopher T

“…The alanine racemases are a group of PLP-dependent bacterial enzymes that catalyze the racemization of alanine, providing D-alanine for cell wall synthesis…”
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Nucleophilic re-activation of the PC1 beta-lactamase of Staphylococcus aureus and of the DD-peptidase of Streptomyces R61 after their inactivation by cephalosporins and cephamycins by Faraci, W S, Pratt, R F

“…It has been shown previously [Faraci & Pratt (1985) Biochemistry 24, 903-910; (1986) Biochemistry 25, 2934-2941; (1986) Biochem. J. 238, 309-312] that certain…”
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Racemization of alanine by the alanine racemases from Salmonella typhimurium and Bacillus stearothermophilus: energetic reaction profiles by Faraci, W. Stephen, Walsh, Christopher T

“…Alanine racemases are bacterial pyridoxal 5'-phosphate (PLP) dependent enzymes providing D-alanine as an essential building block for biosynthesis of the…”
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(1-Aminoethyl)boronic acid: a novel inhibitor for Bacillus stearothermophilus alanine racemase and Salmonella typhimurium D-alanine:D-alanine ligase (ADP-forming) by Duncan, Kenneth, Faraci, W. Stephen, Matteson, Donald S, Walsh, Christopher T

“…(1-Aminoethyl)boronic acid (Ala-B), an analogue of alanine in which a boronic acid group replaces the carboxyl group, has been synthesized and found to inhibit…”
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Inhibition of alanine racemase by alanine phosphonate: detection of an imine linkage to pyridoxal 5'-phosphate in the enzyme-inhibitor complex by solid-state 15N nuclear magnetic resonance by COPIE, V, FARACI, W. S, WALSH, C. T, GRIFFIN, R. G

“…Inhibition of alanine racemase from the Gram-positive bacterium Bacillus stearothermophilus by (1-aminoethyl) phosphonic acid (Ala-P) proceeds via a two-step…”
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Phosphodiesterases in the CNS: targets for drug development by Schmidt, Christopher J, Menniti, Frank S, Faraci, W. Stephen

“…The therapeutic and commercial success of phosphodiesterase 5 inhibitors such as Viagra, Levitra and Cialis has sparked renewed interest in the…”
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