Search Results - "FANTOZZI, Roberto"

Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice by Benetti, Elisa, Mastrocola, Raffaella, Chiazza, Fausto, Nigro, Debora, D'Antona, Giuseppe, Bordano, Valentina, Fantozzi, Roberto, Aragno, Manuela, Collino, Massimo, Minetto, Marco Alessandro

“…Epidemiological studies pointed out to a strong association between vitamin D deficiency and type 2 diabetes prevalence. However, the role of vitamin D…”
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Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R by Sivarajah, Ahila, Collino, Massimo, Yasin, Mohammed, Benetti, Elisa, Gallicchio, Margherita, Mazzon, Emanuela, Cuzzocrea, Salvatore, Fantozzi, Roberto, Thiemermann, Christoph

“…Hydrogen sulfide (H2S) is a novel gaseous mediator produced by cystathionine-beta-synthase and cystathionine-gamma-lyase in the cardiovascular system,…”
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Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis by Cannito, Stefania, Morello, Elisabetta, Bocca, Claudia, Foglia, Beatrice, Benetti, Elisa, Novo, Erica, Chiazza, Fausto, Rogazzo, Mara, Fantozzi, Roberto, Povero, Davide, Sutti, Salvatore, Bugianesi, Elisabetta, Feldstein, Ariel E, Albano, Emanuele, Collino, Massimo, Parola, Maurizio

“…Non-Alcoholic Fatty Liver Disease (NAFLD) is a major form of chronic liver disease in the general population in relation to its high prevalence among…”
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Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells by Minelli, Rosalba, Cavalli, Roberta, Ellis, Leigh, Pettazzoni, Piergiorgio, Trotta, Francesco, Ciamporcero, Eric, Barrera, Giuseppina, Fantozzi, Roberto, Dianzani, Chiara, Pili, Roberto

“…Camptothecin (CPT) is a potent DNA Topoisomerase I inhibitor with anti-tumor activity in hematological and solid tumors. However, it did not reach clinical use…”
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B7h triggering inhibits the migration of tumor cell lines by Dianzani, Chiara, Minelli, Rosalba, Gigliotti, Casimiro Luca, Occhipinti, Sergio, Giovarelli, Mirella, Conti, Laura, Boggio, Elena, Shivakumar, Yogesh, Baldanzi, Gianluca, Malacarne, Valeria, Orilieri, Elisabetta, Cappellano, Giuseppe, Fantozzi, Roberto, Sblattero, Daniele, Yagi, Junji, Rojo, Josè Maria, Chiocchetti, Annalisa, Dianzani, Umberto

“…Vascular endothelial cells (ECs) and several cancer cells express B7h, which is the ligand of the ICOS T cell costimulatory molecule. We have previously shown…”
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Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors by Gigliotti, Casimiro Luca, Ferrara, Benedetta, Occhipinti, Sergio, Boggio, Elena, Barrera, Giuseppina, Pizzimenti, Stefania, Giovarelli, Mirella, Fantozzi, Roberto, Chiocchetti, Annalisa, Argenziano, Monica, Clemente, Nausicaa, Trotta, Francesco, Marchiò, Caterina, Annaratone, Laura, Boldorini, Renzo, Dianzani, Umberto, Cavalli, Roberta, Dianzani, Chiara

“…Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed…”
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Protective effects of peroxisome proliferator‐activated receptor agonists on human podocytes: proposed mechanisms of action by Miglio, Gianluca, Rosa, Arianna Carolina, Rattazzi, Lorenza, Grange, Cristina, Camussi, Giovanni, Fantozzi, Roberto

“…BACKGROUND AND PURPOSE Peroxisome proliferator‐activated receptor (PPAR) agonists exert anti‐albuminuric effects. However, the nephroprotective effects of…”
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Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses by Di Nicolantonio, Federica, Arena, Sabrina, Gallicchio, Margherita, Zecchin, Davide, Martini, Miriam, Flonta, Simona Emilia, Stella, Giulia Maria, Lamba, Simona, Cancelliere, Carlotta, Russo, Mariangela, Geuna, Massimo, Appendino, Giovanni, Fantozzi, Roberto, Medico, Enzo, Bardelli, Alberto

“…Mutations in oncogenes and tumor suppressor genes are responsible for tumorigenesis and represent favored therapeutic targets in oncology. We exploited…”
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New chitosan nanospheres for the delivery of 5-fluorouracil: preparation, characterization and in vitro studies by Cavalli, Roberta, Leone, Federica, Minelli, Rosalba, Fantozzi, Roberto, Dianzani, Chiara

“…The aim of this work was to develop new chitosan nanospheres for the delivery of 5-fluorouracil (5-FU). Drug loaded nanospheres were prepared using a technique…”
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Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure by Collino, Massimo, Pini, Alessandro, Mugelli, Niccolò, Mastroianni, Rosanna, Bani, Daniele, Fantozzi, Roberto, Papucci, Laura, Fazi, Marilena, Masini, Emanuela

“…We and others have previously demonstrated that heme oxygenase 1 (HO-1) induction by acute hemin administration exerts cardioprotective effects. Here, we…”
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Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock by Nandra, Kiran K, Collino, Massimo, Rogazzo, Mara, Fantozzi, Roberto, Patel, Nimesh S A, Thiemermann, Christoph

“…Pre-treatment with erythropoietin (EPO) has been demonstrated to exert tissue-protective effects against 'ischemia-reperfusion'-type injuries. This protection…”
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Triggering of B7h by the ICOS modulates maturation and migration of monocyte-derived dendritic cells by Occhipinti, Sergio, Dianzani, Chiara, Chiocchetti, Annalisa, Boggio, Elena, Clemente, Nausicaa, Gigliotti, Casimiro Luca, Soluri, Maria Felicia, Minelli, Rosalba, Fantozzi, Roberto, Yagi, Jungi, Rojo, Josè Maria, Sblattero, Daniele, Giovarelli, Mirella, Dianzani, Umberto

“…B7h, expressed by several cell types, binds ICOS expressed by activated T cells. We have previously shown that B7h triggering by ICOS-Fc inhibits human…”
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High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR-δ Agonism by Benetti, Elisa, Mastrocola, Raffaella, Rogazzo, Mara, Chiazza, Fausto, Aragno, Manuela, Fantozzi, Roberto, Collino, Massimo, Minetto, Marco Alessandro

“…Peroxisome Proliferator Activated Receptor (PPAR)-δ agonists may serve for treating metabolic diseases. However, the effects of PPAR-δ agonism within the…”
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Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? by Atassi, Nazem, Beghi, Ettore, Blanquer, Miguel, Boulis, Nicholas M, Cantello, Roberto, Caponnetto, Claudia, Chiò, Adriano, Dunnett, Stephen B, Feldman, Eva L, Vescovi, Angelo, Mazzini, Letizia

“…Abstract Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. There are…”
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B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells by Dianzani, Chiara, Minelli, Rosalba, Mesturini, Riccardo, Chiocchetti, Annalisa, Barrera, Giuseppina, Boscolo, Sabrina, Sarasso, Chiara, Gigliotti, Casimiro Luca, Sblattero, Daniele, Yagi, Junji, Rojo, Josè Maria, Fantozzi, Roberto, Dianzani, Umberto

“…Vascular endothelial cells (ECs) are key players in leukocyte recruitment into tissues and metastatic dissemination of tumor cells. ECs express B7h, which is…”
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The non‐anticoagulant heparin‐like K5 polysaccharide derivative K5‐N,OSepi attenuates myocardial ischaemia/reperfusion injury by Collino, Massimo, Pini, Alessandro, Mastroianni, Rosanna, Benetti, Elisa, Lanzi, Cecilia, Bani, Daniele, Chini, Jacopo, Manoni, Marco, Fantozzi, Roberto, Masini, Emanuela

“…Heparin and low molecular weight heparins have been demonstrated to reduce myocardial ischaemia/reperfusion (I/R) injury, although their use is hampered by the…”
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Characterization of ionotropic glutamate receptors in human lymphocytes by Lombardi, Grazia, Dianzani, Chiara, Miglio, Gianluca, Canonico, Pier Luigi, Fantozzi, Roberto

“…The effect of L‐glutamate (Glu) on human lymphocyte function was studied by measuring anti‐CD3 monoclonal antibody (mAb) or phytohaemagglutinin (PHA)‐induced…”
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Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury by Collino, Massimo, Castiglia, Sara, Manoni, Marco, Salsini, Liana, Chini, Jacopo, Masini, Emanuela, Fantozzi, Roberto

“…Heparin and low molecular weight heparins may reduce brain damage evoked by ischaemia/reperfusion (I/R) injury, although their use is hampered by the risk of…”
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Substance P‐induced cyclooxygenase‐2 expression in human umbilical vein endothelial cells by Gallicchio, Margherita, Rosa, Arianna Carolina, Benetti, Elisa, Collino, Massimo, Dianzani, Chiara, Fantozzi, Roberto

“…Substance P (SP) is a neuropeptide involved in neurogenic inflammation and an agonist for NK1, NK2, and NK3 receptors. SP induces prostaglandin (PG) production…”
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Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat by Murch, Oliver, Abdelrahman, Maha, Collino, Massimo, Gallicchio, Margherita, Benetti, Elisa, Mazzon, Emanuela, Fantozzi, Roberto, Cuzzocrea, Salvatore, Thiemermann, Christoph

“…OBJECTIVE:Sphingosylphosphorylcholine (SPC) has been reported to activate a variety of G-protein coupled receptors, including S1P1–5, G2A, GPR4, and OGR1…”
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