Search Results - "FALZON, MARY"

Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial by Vaidya, Jayant S, Prof, Wenz, Frederik, Prof, Bulsara, Max, Prof, Tobias, Jeffrey S, Prof, Joseph, David J, Prof, Keshtgar, Mohammed, Prof, Flyger, Henrik L, MD, Massarut, Samuele, MD, Alvarado, Michael, MD, Saunders, Christobel, Prof, Eiermann, Wolfgang, Prof, Metaxas, Marinos, PhD, Sperk, Elena, MD, Sütterlin, Marc, Prof, Brown, Douglas, FRCS, Esserman, Laura, Prof, Roncadin, Mario, MD, Thompson, Alastair, Prof, Dewar, John A, Prof, Holtveg, Helle M R, MD, Pigorsch, Steffi, MD, Falzon, Mary, FRCPath, Harris, Eleanor, MD, Matthews, April, BSc, Brew-Graves, Chris, MSc, Potyka, Ingrid, PhD, Corica, Tammy, BSc, Williams, Norman R, PhD, Baum, Michael, Prof

“…Summary Background The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated…”
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Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial by Vaidya, Jayant S, Dr, Joseph, David J, MD, Tobias, Jeffrey S, FRCR, Bulsara, Max, PhD, Wenz, Frederik, MD, Saunders, Christobel, FRCS, Alvarado, Michael, MD, Flyger, Henrik L, MD, Massarut, Samuele, MD, Eiermann, Wolfgang, MD, Keshtgar, Mohammed, PhD, Dewar, John, FRCR, Kraus-Tiefenbacher, Uta, MD, Sütterlin, Marc, MD, Esserman, Laura, MD, Holtveg, Helle MR, MD, Roncadin, Mario, MD, Pigorsch, Steffi, MD, Metaxas, Marinos, PhD, Falzon, Mary, FRCPath, Matthews, April, BSc, Corica, Tammy, PGDPH, Williams, Norman R, PhD, Baum, Michael, FRCS

“…Summary Background After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers…”
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Pride, Prejudice, or Science: Attitudes Towards the Results of the TARGIT-A Trial of Targeted Intraoperative Radiation Therapy for Breast Cancer by Vaidya, Jayant S., MBBS, MS, DNB, FRCS, PhD, Bulsara, Max, PhD, Wenz, Frederik, MD, Joseph, David, MD, FRCR, Saunders, Christobel, FRCS, Massarut, Samuele, MD, Flyger, Henrik, MD, Eiermann, Wolfgang, MD, Alvarado, Michael, MD, Esserman, Laura, MD, MBA, Falzon, Mary, FRCPath, Brew-Graves, Chris, MSc, Potyka, Ingrid, PhD, Tobias, Jeffrey S., MD, FRCR, Baum, Michael, MBBS, MD, FRCS

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Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors by Teixeira, Vitor H, Nadarajan, Parthiban, Graham, Trevor A, Pipinikas, Christodoulos P, Brown, James M, Falzon, Mary, Nye, Emma, Poulsom, Richard, Lawrence, David, Wright, Nicholas A, McDonald, Stuart, Giangreco, Adam, Simons, Benjamin D, Janes, Sam M

“…Lineage tracing approaches have provided new insights into the cellular mechanisms that support tissue homeostasis in mice. However, the relevance of these…”
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Progressive 3q Amplification Consistently Targets SOX2 in Preinvasive Squamous Lung Cancer by MCCAUGHAN, Frank, POLE, Jessica C. M, BANKIER, Alan T, KONFORTOV, Bernard A, CARROLL, Bernadette, FALZON, Mary, RABBITTS, Terence H, GEORGE, P. Jeremy, DEAR, Paul H, RABBITTS, Pamela H

“…Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial…”
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In Regard to Hepel and Wazer by Vaidya, Jayant S., MBBS, MS, DNB, FRCS, PhD, Bulsara, Max, PhD, Wenz, Frederik, MD, Joseph, David, MD, FRCR, Saunders, Christobel, FRCS, Massarut, Samuele, MD, Flyger, Henrik, MD, Eiermann, Wolfgang, MD, Alvarado, Michael, MD, Esserman, Laura, MD, MBA, Falzon, Mary, FRCPath, Brew-Graves, Chris, MSc, Potyka, Ingrid, PhD, Tobias, Jeffrey S., MD, FRCR, Baum, Michael, MBBS, MD, FRCS

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Tracking the Evolution of Non–Small-Cell Lung Cancer by Jamal-Hanjani, Mariam, Wilson, Gareth A, McGranahan, Nicholas, Birkbak, Nicolai J, Watkins, Thomas B.K, Veeriah, Selvaraju, Shafi, Seema, Johnson, Diana H, Mitter, Richard, Rosenthal, Rachel, Salm, Max, Horswell, Stuart, Escudero, Mickael, Matthews, Nik, Rowan, Andrew, Chambers, Tim, Moore, David A, Turajlic, Samra, Xu, Hang, Lee, Siow-Ming, Forster, Martin D, Ahmad, Tanya, Hiley, Crispin T, Abbosh, Christopher, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M, Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Shah, Rajesh, Joseph, Leena, Quinn, Anne M, Crosbie, Phil A, Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A, Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Dentro, Stefan, Taniere, Philippe, O’Sullivan, Brendan, Lowe, Helen L, Hartley, John A, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Shaw, Jacqui A, Herrero, Javier, Szallasi, Zoltan, Schwarz, Roland F, Stewart, Aengus, Quezada, Sergio A, Le Quesne, John, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Swanton, Charles

“…Distinct genes are mutated in different regions of a single patient’s tumor. Point mutations seem to have less adverse effect on relapse-free survival than…”
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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial by Vaidya, Jayant S, Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R, Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Le Blanc-Onfroy, Magali, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J, Niewald, Marcus, Blohmer, Jens, McCready, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David J, Tobias, Jeffrey S

“…To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast…”
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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution by Abbosh, Christopher, Birkbak, Nicolai J., Wilson, Gareth A., Jamal-Hanjani, Mariam, Constantin, Tudor, Salari, Raheleh, Le Quesne, John, Moore, David A., Veeriah, Selvaraju, Rosenthal, Rachel, Marafioti, Teresa, Kirkizlar, Eser, McGranahan, Nicholas, Ward, Sophia, Martinson, Luke, Riley, Joan, Fraioli, Francesco, Al Bakir, Maise, Grönroos, Eva, Zambrana, Francisco, Endozo, Raymondo, Bi, Wenya Linda, Fennessy, Fiona M., Sponer, Nicole, Johnson, Diana, Laycock, Joanne, Shafi, Seema, Czyzewska-Khan, Justyna, Rowan, Andrew, Chambers, Tim, Matthews, Nik, Hiley, Crispin, Lee, Siow Ming, Forster, Martin D., Ahmad, Tanya, Falzon, Mary, Borg, Elaine, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M., Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Naik, Ashwini, Ganguly, Apratim, Kareht, Stephanie, Shah, Rajesh, Joseph, Leena, Marie Quinn, Anne, Crosbie, Phil A., Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A., Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F., Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Oukrif, Dahmane, Akarca, Ayse U., Hartley, John A., Lowe, Helen L., Lock, Sara, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Elgar, Greg, Szallasi, Zoltan, Schwarz, Roland F., Herrero, Javier, Stewart, Aengus, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Lin, C. Jimmy, Rabinowitz, Matthew, Aerts, Hugo J. W. L., Hackshaw, Allan, Shaw, Jacqui A., Zimmermann, Bernhard G., Swanton, Charles

“…The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic…”
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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal by Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, Lopez, Jose I., Nicol, David, O’Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin, Watkins, Thomas B.K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles

“…Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed…”
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Spatial and temporal diversity in genomic instability processes defines lung cancer evolution by de Bruin, Elza C., McGranahan, Nicholas, Mitter, Richard, Salm, Max, Wedge, David C., Yates, Lucy, Jamal-Hanjani, Mariam, Shafi, Seema, Murugaesu, Nirupa, Rowan, Andrew J., Grönroos, Eva, Muhammad, Madiha A., Horswell, Stuart, Gerlinger, Marco, Varela, Ignacio, Jones, David, Marshall, John, Voet, Thierry, Van Loo, Peter, Rassl, Doris M., Rintoul, Robert C., Janes, Sam M., Lee, Siow-Ming, Forster, Martin, Ahmad, Tanya, Lawrence, David, Falzon, Mary, Capitanio, Arrigo, Harkins, Timothy T., Lee, Clarence C., Tom, Warren, Teefe, Enock, Chen, Shann-Ching, Begum, Sharmin, Rabinowitz, Adam, Phillimore, Benjamin, Spencer-Dene, Bradley, Stamp, Gordon, Szallasi, Zoltan, Matthews, Nik, Stewart, Aengus, Campbell, Peter, Swanton, Charles

“…Spatial and temporal dissection of the genomic changes occurring during the evolution of human non–small cell lung cancer (NSCLC) may help elucidate the basis…”
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Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions by Teixeira, Vitor H., Pipinikas, Christodoulos P., Pennycuick, Adam, Lee-Six, Henry, Chandrasekharan, Deepak, Beane, Jennifer, Morris, Tiffany J., Karpathakis, Anna, Feber, Andrew, Breeze, Charles E., Ntolios, Paschalis, Hynds, Robert E., Falzon, Mary, Capitanio, Arrigo, Carroll, Bernadette, Durrenberger, Pascal F., Hardavella, Georgia, Brown, James M., Lynch, Andy G., Farmery, Henry, Paul, Dirk S., Chambers, Rachel C., McGranahan, Nicholas, Navani, Neal, Thakrar, Ricky M., Swanton, Charles, Beck, Stephan, George, Phillip Jeremy, Spira, Avrum, Campbell, Peter J., Thirlwell, Christina, Janes, Sam M.

“…The molecular alterations that occur in cells before cancer is manifest are largely uncharted. Lung carcinoma in situ (CIS) lesions are the pre-invasive…”
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Suitability of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Specimens for Subtyping and Genotyping of Non―Small Cell Lung Cancer: A Multicenter Study of 774 Patients by NAVAN, Neal, BROWN, James M, KOCJAN, Gabrijela, RINTOUL, Robert C, NICHOLSON, Andrew G, JANES, Sam OM, NANKIVELL, Matthew, WOOLHOUSE, Ian, HARRISON, Richard N, JEEBUN, Vandana, MUNAVVAR, Mohammed, NG, Benjamin J, RASSL, Doris M, FALZON, Mary

“…The current management of advanced non-small cell lung cancer (NSCLC) requires differentiation between squamous and nonsquamous subtypes as well as epidermal…”
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Endobronchial Ultrasound―guided Transbronchial Needle Aspiration Prevents Mediastinoscopies in the Diagnosis of Isolated Mediastinal Lymphadenopathy A Prospective Trial by NAVANI, Neal, LAWRENCE, David R, OMAR, Rumana Z, JANES, Sam M, KOLVEKAR, Shyam, HAYWARD, Martin, MCASEY, Dorcas, KOCJAN, Gabrijela, FALZON, Mary, CAPITANIO, Arrigo, SHAW, Penny, MORRIS, Stephen

“…Patients with isolated mediastinal lymphadenopathy (IML) are a common presentation to physicians, and mediastinoscopy is traditionally considered the "gold…”
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Spindle cell tumour with thymus‐like differentiation (SETTLE) on fine needle aspiration cytology: A case report highlighting diagnostic pitfalls by Adegun, Oluyori K., Proctor, Ian, Falzon, Mary, Pomplun, Sabine

“…A 7‐year‐old girl presented with a painless neck swelling localised near the left lobe of the thyroid gland, which was initially investigated by fine needle…”
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BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma by Ishii, Yuki, Kolluri, Krishna K., Pennycuick, Adam, Zhang, Xidan, Nigro, Ersilia, Alrifai, Doraid, Borg, Elaine, Falzon, Mary, Shah, Khalid, Kumar, Neelam, Janes, Sam M.

“…Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few available…”
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Tracking genomic cancer evolution for precision medicine: the lung TRACERx study by Jamal-Hanjani, Mariam, Hackshaw, Alan, Ngai, Yenting, Shaw, Jacqueline, Dive, Caroline, Quezada, Sergio, Middleton, Gary, de Bruin, Elza, Le Quesne, John, Shafi, Seema, Falzon, Mary, Horswell, Stuart, Blackhall, Fiona, Khan, Iftekhar, Janes, Sam, Nicolson, Marianne, Lawrence, David, Forster, Martin, Fennell, Dean, Lee, Siow-Ming, Lester, Jason, Kerr, Keith, Muller, Salli, Iles, Natasha, Smith, Sean, Murugaesu, Nirupa, Mitter, Richard, Salm, Max, Stuart, Aengus, Matthews, Nik, Adams, Haydn, Ahmad, Tanya, Attanoos, Richard, Bennett, Jonathan, Birkbak, Nicolai Juul, Booton, Richard, Brady, Ged, Buchan, Keith, Capitano, Arrigo, Chetty, Mahendran, Cobbold, Mark, Crosbie, Philip, Davies, Helen, Denison, Alan, Djearman, Madhav, Goldman, Jacki, Haswell, Tom, Joseph, Leena, Kornaszewska, Malgorzata, Krebs, Matthew, Langman, Gerald, MacKenzie, Mairead, Millar, Joy, Morgan, Bruno, Naidu, Babu, Nonaka, Daisuke, Peggs, Karl, Pritchard, Catrin, Remmen, Hardy, Rowan, Andrew, Shah, Rajesh, Smith, Elaine, Summers, Yvonne, Taylor, Magali, Veeriah, Selvaraju, Waller, David, Wilcox, Ben, Wilcox, Maggie, Woolhouse, Ian, McGranahan, Nicholas, Swanton, Charles

“…The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome…”
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Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer by Pennycuick, Adam, Teixeira, Vitor H, AbdulJabbar, Khalid, Raza, Shan E Ahmed, Lund, Tom, Akarca, Ayse U, Rosenthal, Rachel, Kalinke, Lukas, Chandrasekharan, Deepak P, Pipinikas, Christodoulos P, Lee-Six, Henry, Hynds, Robert E, Gowers, Kate H C, Henry, Jake Y, Millar, Fraser R, Hagos, Yeman B, Denais, Celine, Falzon, Mary, Moore, David A, Antoniou, Sophia, Durrenberger, Pascal F, Furness, Andrew J, Carroll, Bernadette, Marceaux, Claire, Asselin-Labat, Marie-Liesse, Larson, William, Betts, Courtney, Coussens, Lisa M, Thakrar, Ricky M, George, Jeremy, Swanton, Charles, Thirlwell, Christina, Campbell, Peter J, Marafioti, Teresa, Yuan, Yinyin, Quezada, Sergio A, McGranahan, Nicholas, Janes, Sam M

“…Before squamous cell lung cancer develops, precancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such…”
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New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer by Vaidya, Jayant S., Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R., Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Blanc-Onfroy, Magali Le, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J., Niewald, Marcus, Blohmer, Jens, McReady, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David, Tobias, Jeffrey S.

“…Background The TARGIT-A trial reported risk-adapted targeted intraoperative radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer to be as effective…”
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Randomized Prospective Biomarker Trial of ERCC1 for Comparing Platinum and Nonplatinum Therapy in Advanced Non-Small-Cell Lung Cancer: ERCC1 Trial (ET) by Lee, Siow Ming, Falzon, Mary, Blackhall, Fiona, Spicer, James, Nicolson, Marianne, Chaudhuri, Abhro, Middleton, Gary, Ahmed, Samreen, Hicks, Jonathan, Crosse, Barbara, Napier, Mark, Singer, Julian M, Ferry, David, Lewanski, Conrad, Forster, Martin, Rolls, Sally-Ann, Capitanio, Arrigo, Rudd, Robin, Iles, Natasha, Ngai, Yenting, Gandy, Michael, Lillywhite, Rachel, Hackshaw, Allan

“…Purpose Retrospective studies indicate that expression of excision repair cross complementing group 1 (ERCC1) protein is associated with platinum resistance…”
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