Search Results - "FALOTICO, Robert"

Polymers for drug eluting stents by Parker, Ted, Davé, Vipul, Falotico, Robert

“…Currently approved drug eluting stents (DES) consist of a metallic scaffold and an elutable drug dispersed in a polymer matrix that conformally surrounds the…”
Get more information

Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration by Yetgin, Tuncay, MD, Uitterdijk, André, MSc, te Lintel Hekkert, Maaike, BASc, Merkus, Daphne, PhD, Krabbendam-Peters, Ilona, BASc, van Beusekom, Heleen M.M., PhD, Falotico, Robert, PhD, Serruys, Patrick W., MD, PhD, Manintveld, Olivier C., MD, PhD, van Geuns, Robert-Jan M., MD, PhD, Zijlstra, Felix, MD, PhD, Duncker, Dirk J., MD, PhD

“…Abstract Objectives In the absence of effective clinical pharmacotherapy for prevention of reperfusion-mediated injury, this study re-evaluated the effects of…”
Get full text

Stent-based delivery of sirolimus reduces neointimal formation in a porcine coronary model by SUZUKI, Takeshi, KOPIA, Greg, YEUNG, Alan C, TIO, Fermin, TSAO, Philip S, FALOTICO, Robert, CARTER, Andrew J, HAYASHI, Shin-Ichiro, BAILEY, Lynn R, LLANOS, Gerard, WILENSKY, Robert, KLUGHERZ, Bruce D, PAPANDREOU, George, NARAYAN, Pallassana, LEON, Martin B

“…The purpose of this study was to determine the efficacy of stent-based delivery of sirolimus (SRL) alone or in combination with dexamethasone (DEX) to reduce…”
Get full text

Drug-eluting stents: Sirolimus and paclitaxel differentially affect cultured cells and injured arteries by Parry, Tom J., Brosius, Ruth, Thyagarajan, Rathna, Carter, Demetrius, Argentieri, Dennis, Falotico, Robert, Siekierka, John

“…Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the…”
Get full text

Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries by SOUSA, J. Eduardo, COSTA, Marco A, POPMA, Jeffrey J, SERRUYS, Patrick W, SOUSA, Amanda G. M. R, ABIZAID, Alexandre C, SEIXAS, Ana C, ABIZAID, Andrea S, FERES, Fausto, MATTOS, Luiz A, FALOTICO, Robert, JAEGER, Judith

“…The safety and efficacy of sirolimus-eluting stenting have been demonstrated, but the outcome of patients treated with this novel technology beyond the first…”
Get full text

Microstructure and drug-release studies of sirolimus-containing poly(lactide-co-glycolide) films by Ro, Andrew J., Falotico, Robert, Davé, Vipul

“…Sirolimus‐containing poly(lactide‐co‐glycolide) (PLGA) films were prepared by solution casting and removing the residual solvent, 1,4‐dioxane, by liquid and…”
Get full text

Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stent by Klugherz, Bruce D, Llanos, Gerard, Lieuallen, Warren, Kopia, Gregory A, Papandreou, George, Narayan, Pallassana, Sasseen, Brett, Adelman, Steven J, Falotico, Robert, Wilensky, Robert L

“…BACKGROUNDIn-stent restenosis is caused by neointimal hyperplasia. Sirolimus (rapamycin; Wyeth Research, Radnor, Pennsylvania, USA) inhibits vascular smooth…”
Get full text

The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit by Herbert, J M, Dol, F, Bernat, A, Falotico, R, Lalé, A, Savi, P

“…It is unknown whether the addition of aspirin might increase both the efficacy and the potency of clopidogrel, a potent and selective ADP blocker. For that…”
Get more information

Update on sirolimus drug-eluting stents by Kipshidze, Nicholas, Leon, Martin B, Tsapenko, Mykola, Falotico, Robert, Kopia, Gregory A, Moses, Jeffrey

“…Percutaneous transluminal coronary angioplasty (PTCA) has become the main method of coronary revascularization. However, despite technical advancement,…”
Get more information

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization by Morice, Marie-Claude, Serruys, Patrick W, Sousa, J. Eduardo, Fajadet, Jean, Ban Hayashi, Ernesto, Perin, Marco, Colombo, Antonio, Schuler, G, Barragan, Paul, Guagliumi, Giulio, Molnàr, Ferenc, Falotico, Robert

“…Despite advances in coronary angioplasty and stenting, restenosis remains an important problem that limits clinical success. This study compared a new coronary…”
Get full text

Long-term effects of polymer-based, slow-release, sirolimus-eluting stents in a porcine coronary model by CARTER, Andrew J, AGGARWAL, Meenakshi, KOPIA, Gregory A, TIO, Fermin, TSAO, Philip S, KOLATA, Ron, YEUNG, Alan C, LLANOS, Gerald, DOOLEY, John, FALOTICO, Robert

“…Stent-based delivery of sirolimus (SRL) has shown reduction in neointimal hyperplasia and restenosis. The purpose of this study was to evaluate the chronic…”
Get full text

Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up by Sousa, J E, Costa, M A, Abizaid, A C, Rensing, B J, Abizaid, A S, Tanajura, L F, Kozuma, K, Van Langenhove, G, Sousa, A G, Falotico, R, Jaeger, J, Popma, J J, Serruys, P W

“…We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present…”
Get full text

Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents by SOUSA, J. Eduardo, COSTA, Marco A, SERRUYS, Patrick W, SOUSA, Amanda G. M. R, ABIZAID, Alexandre, FERES, Fausto, SEIXAS, Ana C, TANAJURA, Luiz F, MATTOS, Luiz A, FALOTICO, Robert, JAEGER, Judith, POPMA, Jeffrey J

“…Despite the proven superiority of sirolimus-eluting stents (SESs) compared with bare stents in the first year after implantation, long-term outcomes of…”
Get full text

Lack of neointimal proliferation after implantation of sirolimus-coated stents in human coronary arteries : A quantitative coronary angiography and three-dimensional intravascular ultrasound study by SOUSA, J. Eduardo, COSTA, Marco A, FALOTICO, Robert, JAEGER, Judith, POPMA, Jeffrey J, SERRUYS, Patrick W, ABIZAID, Alexandre, ABIZAID, Andrea S, FERES, Fausto, PINTO, Ibraim M. F, SEIXAS, Ana C, STAICO, Rodolfo, MATTOS, Luiz A, SOUSA, Amanda G. M. R

“…Restenosis remains an important limitation of interventional cardiology. Therefore, we aimed to determine the safety and efficacy of sirolimus (a cell-cycle…”
Get full text

Sirolimus-eluting stent for the treatment of in-stent restenosis: A quantitative coronary angiography and three-dimensional intravascular ultrasound study by SOUSA, J. Eduardo, COSTA, Marco A, FALOTICO, Robert, JAEGER, Judith, POPMA, Jeffrey J, SERRUYS, Patrick W, ABIZAID, Alexandre, SOUSA, Amanda G. M. R, FERES, Fausto, MATTOS, Luiz A, CENTEMERO, Marinella, MALDONADO, Galo, ABIZAID, Andrea S, PINTO, Ibraim

“…We have previously reported the safety and effectiveness of sirolimus-eluting stents for the treatment of de novo coronary lesions. The present investigation…”
Get full text

Morphological and degradation studies of sirolimus-containing poly(lactide-co-glycolide) discs by Ro, Andrew J., Falotico, Robert, Davé, Vipul

“…The effect of residual solvent and copolymer ratio on the in vitro degradation and drug release behavior of a bioabsorbable polymer/drug system was…”
Get full text

A nonelutable low-molecular weight heparin stent coating for improved thromboresistance by Zhao, Jonathon, Falotico, Robert, Nguyen, Thai, Cheng, Yan, Parker, Theodore, Davé, Vipul, Rogers, Campbell, Riesenfeld, Johan

“…Low‐molecular weight heparin (LMWH) has been widely used as a systemic anticoagulant during percutaneous coronary intervention. In this study, LMWH was…”
Get full text

Control of cilostazol release kinetics and direction from a stent using a reservoir-based design by Parker, Theodore, Davé, Vipul, Falotico, Robert, Zhao, Jonathon, Nguyen, Thai, He, Sylvia, Sun, Yi-Ping, Rogers, Campbell

“…Sustained release formulations of a potent antithrombotic drug, cilostazol, in poly‐(lactic acid‐co‐glycolic acid) (PLGA) matrices were created for luminal…”
Get full text

NEVO™: a new generation of sirolimus-eluting coronary stent by Falotico, Robert, Parker, Theodore, Grishaber, Randy, Price, Sylvester, Cohen, Sidney, Rogers, Campbell

Get full text

Comparative healing response after sirolimus- and paclitaxel-eluting stent implantation in a pig model of restenosis by Silva, Guilherme V., Fernandes, Marlos R., Madonna, Rosella, Clubb, Fred, Oliveira, Edie, Jimenez-Quevedo, Pilar, Branco, Rodrigo, Lopez, Javier, Angeli, Franca S., Sanz-Ruiz, Ricardo, Vaughn, William K., Zheng, Yi, Baimbridge, Fred, Canales, John, Cardoso, Cristiano O., Assad, Joao A., Falotico, Robert, Perin, Emerson C.

“…Objective: We compared local vessel healing and inflammatory responses associated with nonoverlapping sirolimus‐eluting stents (SES) and paclitaxel‐eluting…”
Get full text