Search Results - "FALETTE, N"

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics by GALMARINI, C. M, KAMATH, K, VANIER-VIORNERY, A, HERVIEU, V, PEILLER, E, FALETTE, N, PUISIEUX, A, JORDAN, M. Ann, DUMONTET, C

“…In the present study, we compared the dynamics and composition of microtubules in cell lines derived from the human breast adenocarcinoma MCF-7 containing…”
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Paclitaxel resistance in untransformed human mammary epithelial cells is associated with an aneuploidy-prone phenotype by BOUCHET, B. P, BERTHOLON, J, FALETTE, N, AUDOYNAUD, C, LAMBLOT, C, PUISIEUX, A, GALMARINI, C. M

“…Despite its increasing clinical use, almost no data are currently available about paclitaxel effects on non-cancerous mammary epithelial cells. We have…”
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Identification of BTG2 , an antiproliferative p53-dependent component of the DNA damage cellular response pathway by Wang, Qing, Magaud, Jean-Pierre, Rouault, Jean-Pierre, Berger, Roland, Guéhenneux, Fabienne, Pain, Bertrand, Berthet, Cyril, Samarut, Christiane, Moyret-Lalle, Caroline, Guillot, Céline, Samarut, Jacques, Shaw, Philip, Rimokh, Ruth, Falette, Nicole, Puisieux, Alain, Ozturk, Mehmet, Savatier, Pierre

“…Cell cycle regulation is critical for maintenance of genome integrity. A prominent factor that guarantees genomic stability of cells is p53 (ref. 1). The P53…”
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Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity by GALMARINI, C. M, FALETTE, N, TABONE, E, LEVRAT, C, BRITTEN, R, VOORZANGER-ROUSSELOT, N, ROESCH-GATEAU, O, VANIER-VIORNERY, A, PUISIEUX, A, DUMONTET, C

“…The present study was performed to gain insight into the role of p53 on the cytotoxicity of tubulin-binding agents (TBA) on cancer cells. Drug sensitivity,…”
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Sensitive detection of estrogen receptor RNA by polymerase chain reaction assay by Fuqua, S A, Falette, N F, McGuire, W L

“…We developed a simplified polymerase chain reaction (PCR) technique sensitive enough to detect estrogen receptor (ER) mRNA in breast tumor specimens from 1…”
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Alteration of p53 damage response by tamoxifen treatment by GUILLOT, C, FALETTE, N, COURTOIS, S, VOELTZEL, T, GARCIA, E, OZTURK, M, PUISIEUX, A

“…Hormone therapy is often used in association with chemotherapy in the treatment of estrogen-responsive breast cancers. By using breast adenocarcinoma cell…”
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Estrogen receptor gene methylation in human breast tumors by FALETTE, N. S, FUQUA, S. A. W, CHAMNESS, G. C, CHEAH, M. S, GREENE, G. L, MCGUIRE, W. L

“…DNA methylation is known to be involved in eukaryotic gene control; it may thus exert effects during development and tumorigenesis. We have examined the…”
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Analysis of epidermal growth factor receptor mRNA expression by polymerase chain reaction assay in 94 human breast adenocarcinoma tumors by FALETTE, N. S, ARTAGAVEYTIA, N, ROSTAN, M. C, GARIN, E, BOBIN, J. Y, SAEZ, S

“…It is well known that breast cancer cells can synthesize and secrete various growth factors that are able to stimulate tumor growth through autocrine and/or…”
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Increased epidermal growth factor receptor level in breast cancer cells treated by 1,25-dihydroxyvitamin D3 by Falette, N, Frappart, L, Lefebvre, M F, Saez, S

“…The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on epidermal growth factor receptor (EGF-R) level regulation was investigated on a human breast cancer…”
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BTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells by el-Ghissassi, Fatiha, Valsesia-Wittmann, Sandrine, Falette, Nicole, Duriez, Cyril, Walden, Paul D, Puisieux, Alain

“…The p53-transcriptional target, BTG2(TIS21/PC3), was previously identified as an antiproliferative gene. However, the precise biological functions of the…”
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Growth inhibitory effect of 4-hydroxy-tamoxifen on the BT-20 mammary cancer cell line by Chouvet, C, Vicard, E, Frappart, L, Falette, N, Lefebvre, M F, Saez, S

“…The antiestrogenic activities of Tamoxifen have been well documented and this molecule has been successfully used in the treatment of hormone dependent breast…”
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Expression of a non‐functional p53 affects the sensitivity of cancer cells to gemcitabine by Galmarini, Carlos María, Clarke, Marilyn L., Falette, Nicole, Puisieux, Alain, Mackey, John R., Dumontet, Charles

“…Gemcitabine is a relatively new agent with promising activity in solid tumors. Few data are available regarding mechanisms of resistance to gemcitabine…”
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The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene by Duriez, Cyril, Falette, Nicole, Audoynaud, Carole, Moyret-Lalle, Caroline, Bensaad, Karim, Courtois, Stéphanie, Wang, Qing, Soussi, Thierry, Puisieux, Alain

“…BTG2/TIS21/PC3 protein is involved in the regulation of G1/S transition of the cell cycle by inhibiting pRb function, suggesting that BTG2/TIS21/PC3 regulation…”
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Chfr inactivation is not associated to chromosomal instability in colon cancers by BERTHOLON, Jacques, QING WANG, FALETTE, Nicole, VERNY, Carole, AUCLAIR, Jessie, CHASSOT, Christelle, NAVARRO, Claudine, SAURIN, Jean-Christophe, PUISIEUX, Alain

“…Numerous observations suggest that chromosome instability is caused by mitotic abnormalities such as errors in the partitioning of chromosomes. Chfr was…”
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Influence of p53 and p21(WAF1) expression on sensitivity of cancer cells to cladribine by Galmarini, Carlos María, Voorzanger, Nathalie, Falette, Nicole, Jordheim, Lars, Cros, Emeline, Puisieux, Alain, Dumontet, Charles

“…The present study was performed to gain insight into the role of p53 and p21(WAF1) on the cytotoxicity of the purine analogue cladribine (2-CdA) on cancer…”
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Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients by FALETTE, N, PAPERIN, M.-P, OZTURK, M, PUISIEUX, A, TREILLEUX, I, GRATADOUR, A.-C, PELOUX, N, MIGNOTTE, H, TOOKE, N, LÖFMAN, E, INGANÄS, M, BREMOND, A

“…The most important subgroup of breast cancer patients for which reliable prognostic factors are needed are women without axillary lymph node involvement…”
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BTG gene expression in the p53-dependent and -independent cellular response to DNA damage by Cortes, Ulrich, Moyret-Lalle, Caroline, Falette, Nicole, Duriez, Cyril, Ghissassi, Fatiha El, Barnas, Christophe, Morel, Anne-Pierre, Hainaut, Pierre, Magaud, Jean-Pierre, Puisieux, Alain

“…Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage,…”
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Absence of p53-dependent induction of the metastatic suppressor KAI1 gene after DNA damage by Duriez, C, Falette, N, Cortes, U, Moyret-Lalle, C, Puisieux, A

“…The p53 tumor suppressor protein functions to monitor the integrity of the genome. If a damage is detected, p53 binds tightly to specific sequence elements in…”
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BTG2 super(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells by el-Ghissassi, F, Valsesia-Wittmann, S, Falette, N, Duriez, C, Walden, P D, Puisieux, A

“…The p53-transcriptional target, BTG2 super(TIS21/PC3), was previously identified as an antiproliferative gene. However, the precise biological functions of the…”
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p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours by Guillot, C, Falette, N, Paperin, M P, Courtois, S, Gentil-Perret, A, Treilleux, I, Ozturk, M, Puisieux, A

“…Functional inactivation of the wild-type p53 protein has been described in different human cancers. Since a significant proportion of breast tumours express…”
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