Search Results - "FAIRLIE, W. D"

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia by Mason, K D, Khaw, S L, Rayeroux, K C, Chew, E, Lee, E F, Fairlie, W D, Grigg, A P, Seymour, J F, Szer, J, Huang, D C S, Roberts, A W

“…As chronic lymphocytic leukemia (CLL) is characterized by overexpression of pro-survival BCL2, compounds that mimic its physiological antagonists, the BH3-only…”
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MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation by Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H‐P., Breit, S. N.

“…As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor β (TGF‐β)…”
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Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays by Wong, C, Anderson, D J, Lee, E F, Fairlie, W D, Ludlam, M J C

“…Bcl-2 family proteins have important roles in tumor initiation, progression and resistance to therapy. Pro-survival Bcl-2 proteins are regulated by their…”
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The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women by MOORE, A. G, BROWN, D. A, FAIRLIE, W. D, BAUSKIN, A. R, BROWN, P. K, MUNIER, M. L. C, RUSSELL, P. K, SALAMONSEN, L. A, WALLACE, E. M, BREIT, S. N

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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family by Lee, E F, Czabotar, P E, Smith, B J, Deshayes, K, Zobel, K, Colman, P M, Fairlie, W D

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Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax by Hockings, C, Anwari, K, Ninnis, R L, Brouwer, J, O'Hely, M, Evangelista, M, Hinds, M G, Czabotar, P E, Lee, E F, Fairlie, W D, Dewson, G, Kluck, R M

“…The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation,…”
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Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands by Kvansakul, M, Yang, H, Fairlie, W D, Czabotar, P E, Fischer, S F, Perugini, M A, Huang, D C S, Colman, P M

“…Apoptosis is an important part of the host's defense mechanism for eliminating invading pathogens. Some viruses express proteins homologous in sequence and…”
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Antibody-based approach to high-volume genotyping for MIC-1 polymorphism by Brown, D A, Bauskin, A R, Fairlie, W D, Smith, M D, Liu, T, Xu, N, Breit, S N

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. There are at least two known alleles of MIC-1 that are due to a…”
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CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13 by Fairlie, W D, Perugini, M A, Kvansakul, M, Chen, L, Huang, D C S, Colman, P M

“…The pathway to cell death in Caenorhabditis elegans is well established. In cells undergoing apoptosis, the Bcl-2 homology domain 3 (BH3)-only protein EGL-1…”
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BCL-XL is an actionable target for treatment of malignant pleural mesothelioma by Arulananda, Surein, O’Brien, Megan, Evangelista, Marco, Harris, Tiffany J., Steinohrt, Nikita S., Jenkins, Laura J., Walkiewicz, Marzena, O’Donoghue, Robert J. J., Poh, Ashleigh R., Thapa, Bibhusal, Williams, David S., Leong, Trishe, Mariadason, John M., Li, Xia, Cebon, Jonathan, Lee, Erinna F., John, Thomas, Fairlie, W. D.

“…Despite having one of the lowest survival rates of all cancers, there have been no new approved treatments for malignant pleural mesothelioma (MPM) in over a…”
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Functional genomics approaches in parasitic helminths by HAGEN, J., LEE, E. F., FAIRLIE, W. D., KALINNA, B. H.

“…Summary As research on parasitic helminths is moving into the post‐genomic era, an enormous effort is directed towards deciphering gene function and to achieve…”
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Characterisation of a novel A1-specific monoclonal antibody by Lang, M J, Brennan, M S, O'Reilly, L A, Ottina, E, Czabotar, P E, Whitlock, E, Fairlie, W D, Tai, L, Strasser, A, Herold, M J

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Relaxin and Prostaglandin E2 Regulate Interleukin 11 during Human Endometrial Stromal Cell Decidualization by Dimitriadis, E., Stoikos, C., Baca, M., Fairlie, W. D., McCoubrie, J. E., Salamonsen, L. A.

“…Decidualization of endometrial stromal cells and IL-11 signaling are essential for embryo implantation in the mouse. We investigated the effects of relaxin…”
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A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo by Lee, E F, Takiguchi, M, Pettikiriarachchi, A, Evangelista, M, Huang, D C S, Dickins, R A, Fairlie, W D

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Epitope Mapping of the Transforming Growth Factor-β Superfamily Protein, Macrophage Inhibitory Cytokine-1 (MIC-1):  Identification of at Least Five Distinct Epitope Specificities by Fairlie, W. Douglas, Russell, Patricia K, Wu, Wan M, Moore, Anthony G, Zhang, Hong-Ping, Brown, Peter K, Bauskin, Asne R, Breit, Samuel N

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the transforming growth factor-β (TGF-β) superfamily whose increased expression is associated…”
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EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency by Lee, E F, Chen, L, Yang, H, Colman, P M, Huang, D C S, Fairlie, W D

“…Studies of the cell death pathway in the nematode Caenorhabditis elegans provided the first evidence of the evolutionary conservation of apoptosis signalling…”
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Relaxin and Prostaglandin E 2 Regulate Interleukin 11 during Human Endometrial Stromal Cell Decidualization by Dimitriadis, E., Stoikos, C., Baca, M., Fairlie, W. D., McCoubrie, J. E., Salamonsen, L. A.

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MIC-1, a Novel Macrophage Inhibitory Cytokine, is a Divergent Member of the TGF-β superfamily by Bootcov, Michelle R., Bauskin, Asne R., Valenzuela, Stella M., Moore, Anthony G., Bansal, Mohinder, He, Xiao Yan, Zhang, Hong Ping, Donnellan, Melissa, Mahler, Stephen, Pryor, Kimberley, Walsh, Bradley J., Nicholson, Richard C., Fairlie, W. Douglas, Por, Suzanne B., Robbins, Joan M., Breit, Samuel N.

“…Macrophages play a key role in both normal and pathological processes involving immune and inflammatory responses, to a large extent through their capacity to…”
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Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1 by ALBERTONI, Michele, SHAW, Phillip H, VAN MEIR, Erwin G, HEGI, Monika E, NOZAKI, Michimasa, GODARD, Sophie, TENAN, Mirna, HAMOU, Marie-France, FAIRLIE, Douglas W, BREIT, Samuel N, PARALKAR, Vishwas M, DE TRIBOLET, Nicolas

“…Human astrocytic brain tumors select for mutations in the p53 tumor suppressor gene early in malignant progression. p53 is activated upon various kinds of…”
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Screening procedure for Pichia pastoris clones containing multiple copy gene inserts by Fairlie, W D, Russell, P K, Zhang, H P, Breit, S N

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