Search Results - "FAIRLIE, D. P"

Function, structure and therapeutic potential of complement C5a receptors by Monk, P N, Scola, A‐M, Madala, P, Fairlie, D P

“…Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to…”
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Biased signalling and proteinase‐activated receptors (PARs): targeting inflammatory disease by Hollenberg, M D, Mihara, K, Polley, D, Suen, J Y, Han, A, Fairlie, D P, Ramachandran, R

“…Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in tissues, it took until the 1990s to discover that serine…”
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Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) by Suen, JY, Barry, GD, Lohman, RJ, Halili, MA, Cotterell, AJ, Le, GT, Fairlie, DP

“…BACKGROUND AND PURPOSE Many cells express proteinase activated receptor 2 (PAR2) on their plasma membrane. PAR2 is activated by proteolytic enzymes, such as…”
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Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues by ANDREWS, K. T, TRAN, T. N, LUCKE, A. J, KAHNBERG, P, LE, G. T, BOYLE, G. M, GARDINER, D. L, SKINNER-ADAMS, T. S, FAIRLIE, D. P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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New insights into growth hormone action by Waters, M J, Hoang, H N, Fairlie, D P, Pelekanos, R A, Brown, R J

“…It has been 75 years since Evans and Long identified a somatic growth-promoting substance in pituitary extracts, yet it is only in the last 20 years that the…”
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Histone deacetylase inhibitors and periodontal bone loss by Cantley, M. D., Bartold, P. M., Marino, V., Fairlie, D. P., Le, G. T., Lucke, A. J., Haynes, D. R.

“…Cantley MD, Bartold PM, Marino V, Fairlie DP, Le GT, Lucke AJ, Haynes DR. Histone deacetylase inhibitors and periodontal bone loss. J Periodont Res 2011; 46:…”
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Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease‐activated receptor‐2 by Lieu, T, Savage, E, Zhao, P, Edgington‐Mitchell, L, Barlow, N, Bron, R, Poole, D P, McLean, P, Lohman, R‐J, Fairlie, D P, Bunnett, N W

“…Background and Purpose Diverse proteases cleave protease‐activated receptor‐2 (PAR2) on primary sensory neurons and epithelial cells to evoke pain and…”
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Pathway‐selective antagonism of proteinase activated receptor 2 by Suen, J Y, Cotterell, A, Lohman, R J, Lim, J, Han, A, Yau, M K, Liu, L, Cooper, M A, Vesey, D A, Fairlie, D P

“…Background and Purpose Proteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to…”
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Protease Inhibitors:  Current Status and Future Prospects by Leung, Donmienne, Abbenante, Giovanni, Fairlie, David P

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Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches by Brayden, D.J., Hill, T.A., Fairlie, D.P., Maher, S., Mrsny, R.J.

“…In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics especially peptides and proteins. In the intervening period,…”
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Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling by Suen, J.Y., Adams, M.N., Lim, J., Madala, P.K., Xu, W., Cotterell, A.J., He, Y., Yau, M.K., Hooper, J.D., Fairlie, D.P.

“…[Display omitted] Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor involved in metabolism, inflammation, and cancers. It is activated by…”
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Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals by Chen, Z, Wang, H, D'Souza, C, Sun, S, Kostenko, L, Eckle, S B G, Meehan, B S, Jackson, D C, Strugnell, R A, Cao, H, Wang, N, Fairlie, D P, Liu, L, Godfrey, D I, Rossjohn, J, McCluskey, J, Corbett, A J

“…Despite recent breakthroughs in identifying mucosal-associated invariant T (MAIT) cell antigens (Ags), the precise requirements for in vivo MAIT cell responses…”
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West Nile Virus NS2B/NS3 protease as an antiviral target by Chappell, K J, Stoermer, M J, Fairlie, D P, Young, P R

“…West Nile Virus (WNV) has spread rapidly during the last decade across five continents causing disease and fatalities in humans and mammals. It highlights the…”
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Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate by QIU, L, KEISO, M. J, HANSEN, C, WEST, M. L, FAIRLIE, D. P, PARSONS, P. G

“…A series of hydroxamates, which are not metalloprotease inhibitors, have been found to be selectively toxic to a range of transformed and human tumour cells…”
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Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases by Tyndall, J D, Fairlie, D P

“…It has been previously demonstrated that aspartic, serine, metallo and cysteine proteases bind to their inhibitors and substrate analogues in a single…”
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The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis by Cantley, M. D., Bartold, P. M., Marino, V., Reid, R. C., Fairlie, D. P., Wyszynski, R. N., Zilm, P. S., Haynes, D. R.

“…Background and Objective:  Live‐animal micro‐computed tomography is a new and promising technique that can be used to quantify changes in bone volume for…”
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Histone deacetylases (HDAC) in physiological and pathological bone remodelling by Cantley, M.D, Zannettino, A.C.W, Bartold, P.M, Fairlie, D.P, Haynes, D.R

“…Abstract Histone deacetylases (HDACs) play important roles in the epigenetic regulation of gene expression in cells and are emerging therapeutic targets for…”
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Low-Molecular-Weight Peptidic and Cyclic Antagonists of the Receptor for the Complement Factor C5a by Finch, Angela M, Wong, Allan K, Paczkowski, Natalii J, Wadi, S. Khémar, Craik, David J, Fairlie, David P, Taylor, Stephen M

“…Activation of the human complement system of plasma proteins during immunological host defense can result in overproduction of potent proinflammatory peptides…”
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Is Oxidative Damage by β-Amyloid and Prion Peptides Mediated by Hydrogen Atom Transfer from Glycine α-Carbon to Methionine Sulfur within β-Sheets? by Rauk, Arvi, Armstrong, David A, Fairlie, David P

“…Methionine in glycine-rich regions of both β-amyloid peptide and prion peptide is thought to be crucial to their neurotoxic properties. We postulate here a…”
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Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis by Lohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J, Cotterell, Adam, Gupta, Praveer, Reid, Robert C, Vesey, David A, Sweet, Matthew J, Fairlie, David P

“…Vorinostat and other inhibitors of different histone deacetylase (HDAC) enzymes are currently being sought to modulate a variety of human conditions, including…”
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