Search Results - "FAGIN, James A"

Biologic and Clinical Perspectives on Thyroid Cancer by Fagin, James A, Wells, Samuel A

“…As in many cancers, genetic analysis of thyroid cancers has identified subgroups that differ in their pathogenesis and has defined targets that make the cancer…”
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Therapeutic breakthroughs for metastatic thyroid cancer by Tiedje, Vera, Fagin, James A.

“…Multikinase inhibitors are effective treatments for thyroid cancers, acting primarily as antiangiogenic agents. This year, advances have been made in selective…”
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Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers by Landa, Iñigo, Ibrahimpasic, Tihana, Boucai, Laura, Sinha, Rileen, Knauf, Jeffrey A, Shah, Ronak H, Dogan, Snjezana, Ricarte-Filho, Julio C, Krishnamoorthy, Gnana P, Xu, Bin, Schultz, Nikolaus, Berger, Michael F, Sander, Chris, Taylor, Barry S, Ghossein, Ronald, Ganly, Ian, Fagin, James A

“…Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to…”
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An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling by Karoulia, Zoi, Wu, Yang, Ahmed, Tamer A., Xin, Qisheng, Bollard, Julien, Krepler, Clemens, Wu, Xuewei, Zhang, Chao, Bollag, Gideon, Herlyn, Meenhard, Fagin, James A., Lujambio, Amaia, Gavathiotis, Evripidis, Poulikakos, Poulikos I.

“…The complex biochemical effects of RAF inhibitors account for both the effectiveness and mechanisms of resistance to these drugs, but a unified mechanistic…”
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Frequent Somatic TERT Promoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease by Landa, Iñigo, Ganly, Ian, Chan, Timothy A, Mitsutake, Norisato, Matsuse, Michiko, Ibrahimpasic, Tihana, Ghossein, Ronald A, Fagin, James A

“…Background: TERT encodes the reverse transcriptase component of telomerase, which adds telomere repeats to chromosome ends, thus enabling cell replication…”
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Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance by Tuttle, R Michael, Fagin, James A, Minkowitz, Gerald, Wong, Richard J, Roman, Benjamin, Patel, Snehal, Untch, Brian, Ganly, Ian, Shaha, Ashok R, Shah, Jatin P, Pace, Mark, Li, Duan, Bach, Ariadne, Lin, Oscar, Whiting, Adrian, Ghossein, Ronald, Landa, Inigo, Sabra, Mona, Boucai, Laura, Fish, Stephanie, Morris, Luc G T

“…Active surveillance of low-risk papillary thyroid cancer (PTC) is now an accepted alternative to immediate surgery, but experience with this approach outside…”
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Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes by Ganly, Ian, Makarov, Vladimir, Deraje, Shyamprasad, Dong, YiYu, Reznik, Ed, Seshan, Venkatraman, Nanjangud, Gouri, Eng, Stephanie, Bose, Promita, Kuo, Fengshen, Morris, Luc G.T., Landa, Inigo, Carrillo Albornoz, Pedro Blecua, Riaz, Nadeem, Nikiforov, Yuri E., Patel, Kepal, Umbricht, Christopher, Zeiger, Martha, Kebebew, Electron, Sherman, Eric, Ghossein, Ronald, Fagin, James A., Chan, Timothy A.

“…The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we describe a comprehensive genomic characterization of 56 primary HCC…”
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Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial by WELLS, Samuel A, ROBINSON, Bruce G, READ, Jessica, LANGMUIR, Peter, RYAN, Anderson J, SCHLUMBERGER, Martin J, GAGEL, Robert F, DRALLE, Henning, FAGIN, James A, SANTORO, Massimo, BAUDIN, Eric, ELISEI, Rossella, JARZAB, Barbara, VASSELLI, James R

“…There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular…”
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Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas by Lito, Piro, Pratilas, Christine A., Joseph, Eric W., Tadi, Madhavi, Halilovic, Ensar, Zubrowski, Matthew, Huang, Alan, Wong, Wai Lin, Callahan, Margaret K., Merghoub, Taha, Wolchok, Jedd D., de Stanchina, Elisa, Chandarlapaty, Sarat, Poulikakos, Poulikos I., Fagin, James A., Rosen, Neal

“…BRAFV600E drives tumors by dysregulating ERK signaling. In these tumors, we show that high levels of ERK-dependent negative feedback potently suppress…”
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Association between BRAF V600E mutation and recurrence of papillary thyroid cancer by Xing, Mingzhao, Alzahrani, Ali S, Carson, Kathryn A, Shong, Young Kee, Kim, Tae Yong, Viola, David, Elisei, Rossella, Bendlová, Bela, Yip, Linwah, Mian, Caterina, Vianello, Federica, Tuttle, R Michael, Robenshtok, Eyal, Fagin, James A, Puxeddu, Efisio, Fugazzola, Laura, Czarniecka, Agnieszka, Jarzab, Barbara, O'Neill, Christine J, Sywak, Mark S, Lam, Alfred K, Riesco-Eizaguirre, Garcilaso, Santisteban, Pilar, Nakayama, Hirotaka, Clifton-Bligh, Roderick, Tallini, Giovanni, Holt, Elizabeth H, Sýkorová, Vlasta

“…To investigate the prognostic value of BRAF V600E mutation for the recurrence of papillary thyroid cancer (PTC). This was a retrospective multicenter study of…”
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Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system by Tuttle, R Michael, Tala, Hernan, Shah, Jatin, Leboeuf, Rebecca, Ghossein, Ronald, Gonen, Mithat, Brokhin, Matvey, Omry, Gal, Fagin, James A, Shaha, Ashok

“…A risk-adapted approach to management of thyroid cancer requires risk estimates that change over time based on response to therapy and the course of the…”
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Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns by Rivera, Michael, Ricarte-Filho, Julio, Knauf, Jeff, Shaha, Ashok, Tuttle, Michael, Fagin, James A, Ghossein, Ronald A

“…The follicular variant of papillary thyroid carcinoma usually presents as an encapsulated tumor and less commonly as a partially/non-encapsulated infiltrative…”
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Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer by Ho, Alan L, Grewal, Ravinder K, Leboeuf, Rebecca, Sherman, Eric J, Pfister, David G, Deandreis, Desiree, Pentlow, Keith S, Zanzonico, Pat B, Haque, Sofia, Gavane, Somali, Ghossein, Ronald A, Ricarte-Filho, Julio C, Domínguez, José M, Shen, Ronglai, Tuttle, R. Michael, Larson, Steve M, Fagin, James A

“…Inhibition of mitogen-activated protein kinase resulted in an increase in expression of the sodium–iodide symporter in 12 of 20 patients, 8 of whom had…”
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Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies by Landa, Iñigo, Pozdeyev, Nikita, Korch, Christopher, Marlow, Laura A, Smallridge, Robert C, Copland, John A, Henderson, Ying C, Lai, Stephen Y, Clayman, Gary L, Onoda, Naoyoshi, Tan, Aik Choon, Garcia-Rendueles, Maria E R, Knauf, Jeffrey A, Haugen, Bryan R, Fagin, James A, Schweppe, Rebecca E

“…Thyroid cancer cell lines are valuable models but have been neglected in pancancer genomic studies. Moreover, their misidentification has been a significant…”
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Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression by Ryder, Mabel, Gild, Matti, Hohl, Tobias M, Pamer, Eric, Knauf, Jeff, Ghossein, Ronald, Joyce, Johanna A, Fagin, James A

“…Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced…”
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International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma by Xu, Bin, Fuchs, Talia L, Ahmadi, Sara, Alghamdi, Mohammed, Alzumaili, Bayan, Bani, Mohamed-Amine, Baudin, Eric, Chou, Angela, De Leo, Antonio, Fagin, James A, Ganly, Ian, Glover, Anthony, Hartl, Dana, Kanaan, Christina, Khneisser, Pierre, Najdawi, Fedaa, Nigam, Aradhya, Papachristos, Alex, Repaci, Andrea, Spanheimer, Philip M, Solaroli, Erica, Untch, Brian R, Barletta, Justine A, Tallini, Giovanni, Al Ghuzlan, Abir, Gill, Anthony J, Ghossein, Ronald A

“…Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor (NET) arising from the calcitonin-producing C cells. Unlike other NETs, there is no…”
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Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules by Nikiforov, Yuri E., Steward, David L., Robinson-Smith, Toni M., Haugen, Bryan R., Klopper, Joshua P., Zhu, Zhaowen, Fagin, James A., Falciglia, Mercedes, Weber, Katherine, Nikiforova, Marina N.

“…Context: Thyroid nodules are common in adults, but only a small fraction of them are malignant. Fine-needle aspiration (FNA) with cytological evaluation is the…”
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Immunohistochemical Detection of Mutated BRAF V600E Supports the Clonal Origin of BRAF-Induced Thyroid Cancers Along the Spectrum of Disease Progression by Ghossein, Ronald A, Katabi, Nora, Fagin, James A

“…Background: The mutated BRAF V600E protein has been specifically detected in papillary thyroid carcinomas (PTCs) using immunohistochemical (IHC) analysis. The…”
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Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers by Ricarte-Filho, Julio C, Li, Sheng, Garcia-Rendueles, Maria E R, Montero-Conde, Cristina, Voza, Francesca, Knauf, Jeffrey A, Heguy, Adriana, Viale, Agnes, Bogdanova, Tetyana, Thomas, Geraldine A, Mason, Christopher E, Fagin, James A

“…Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We examined tissues from 26 Ukrainian…”
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Alternative transcription initiation leads to expression of a novel ALK isoform in cancer by Wiesner, Thomas, Lee, William, Obenauf, Anna C., Ran, Leili, Murali, Rajmohan, Zhang, Qi Fan, Wong, Elissa W. P., Hu, Wenhuo, Scott, Sasinya N., Shah, Ronak H., Landa, Iñigo, Button, Julia, Lailler, Nathalie, Sboner, Andrea, Gao, Dong, Murphy, Devan A., Cao, Zhen, Shukla, Shipra, Hollmann, Travis J., Wang, Lu, Borsu, Laetitia, Merghoub, Taha, Schwartz, Gary K., Postow, Michael A., Ariyan, Charlotte E., Fagin, James A., Zheng, Deyou, Ladanyi, Marc, Busam, Klaus J., Berger, Michael F., Chen, Yu, Chi, Ping

“…A novel ALK transcript expressed in a subset of human cancers, arising from a de novo alternative transcription initiation site within the ALK gene, is…”
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