Search Results - "FAGERNESS, P. E"

Pharmacokinetics, Metabolism, and Excretion of Linezolid following an Oral Dose of [14C]Linezolid to Healthy Human Subjects by SLATTER, J. G, STALKER, D. J, STRYD, R. P, PENG, G. W, SHOBE, E. M, FEENSTRA, K. L, WELSHMAN, I. R, BRUSS, J. B, SAMS, J. P, JOHNSON, M. G, SANDERS, P. E, HAUER, M. J, FAGERNESS, P. E

“…Linezolid (Zyvox), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including…”
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Characterization of bropirimine O-glucuronidation in human liver microsomes by Wynalda, M. A., Wynalda, K. M., Amore, B. M., Fagerness, P. E., Wienkers, L. C.

“…1. The antitumour agent bropirimine undergoes significant Phase II conjugation in vivo. Incubation of [14C]bropirimine with human liver microsomes resulted in…”
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Diffusion in HPMC gels. I: Determination of drug and water diffusivity by pulsed-field-gradient spin-echo NMR by PING GAO, FAGERNESS, P. E

“…This work describes diffusivity measurements of drug (adinazolam mesylate) and water in a variety of solutions including polymer gels. Pulsed-field-gradient…”
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Metabolism of the human immunodeficiency virus type 1 reverse transcriptase inhibitor delavirdine in rats by CHANG, M, SOOD, V. K, WILSON, G. J, KLOOSTERMAN, D. A, SANDERS, P. E, HAUER, M. J, FAGERNESS, P. E

“…Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside reverse transcriptase inhibitor currently under development for the treatment of AIDS. The…”
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Identification of the Metabolites of the HIV-1 Reverse Transcriptase Inhibitor Delavirdine in Monkeys by CHANG, M, SOOD, V. K, KLOOSTERMAN, D. A, HAUER, M. J, FAGERNESS, P. E, SANDERS, P. E, VRBANAC, J. J

“…Delavirdine mesylate (U-90152T) is a highly specific nonnucleoside HIV-1 reverse transcriptase inhibitor currently under development for the treatment of AIDS…”
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Oxidation reactions by prostaglandin cyclooxygenase-hydroperoxidase by R W Egan, P H Gale, E M Baptista, K L Kennicott, W J VandenHeuvel, R W Walker, P E Fagerness, F A Kuehl, Jr

“…oxidations of organic sulfides, amines, and even enzymes catalyzed by purified and microsomal forms of prostaglandin cyclooxygenase-hydroperoxidase have been…”
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Preferred conformational state of the N-terminus section of a bovine growth hormone fragment (residues 96-133) in water is an omega loop by Gooley, P R, Carter, S A, Fagerness, P E, MacKenzie, N E

“…The solution structure of a 38-amino-acid-residue, biologically active fragment of bovine growth hormone (bGH96-133) was investigated with a combined nuclear…”
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The 3'-keto-diol equilibrium of trospectomycin sulfate bulk drug and freeze-dried formulation : solid-state carbon-13 cross-polarization magic angle spinning (CP/MAS) and high-resolution carbon-13 nuclear magnetic resonance (NMR) spectroscopy studies by LIKAR, M. D, TAYLOR, R. J, FAGERNESS, P. E, HIYAMA, Y, ROBINS, R. H

“…Understanding how moisture interacts with a drug or formulation is a critical component of product development. This study demonstrates how water affects the…”
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Fluorine-NMR Experiments for High-Throughput Screening:  Theoretical Aspects, Practical Considerations, and Range of Applicability by Dalvit, Claudio, Fagerness, Paul E, Hadden, Daneen T. A, Sarver, Ronald W, Stockman, Brian J

“…Competition ligand-based NMR screening experiments have recently been introduced to overcome most of the problems associated with traditional ligand-based NMR…”
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Biosynthesis of porphyrins and corrins. 2. Isolation, purification, and NMR investigations of the porphobilinogen deaminase covalent complex by Evans, Jeremy N. S, Burton, Gerardo, Fagerness, Paul E, Mackenzie, Neil E, Scott, A. Ian

“…The procedures for the generation of enzyme-substrate complexes from labeled porphobilinogens [(2,11-13C]PBG and [2,6,11-3H]PBG) with deaminase and the methods…”
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Structure of factor S3, a metabolite of Propionibacterium shermanii derived from uroporphyrinogen I by Mueller, G, Schmiedl, J, Schneider, E, Sedlmeier, R, Woerner, G, Scott, A. I, Williams, H. J, Santander, P. J, Stolowich, N. J, et al, .

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Structure of preuroporphyrinogen. Exploration of an enzyme mechanism by carbon-13 and nitrogen-15 NMR spectroscopy by Burton, G, Nordlov, H, Hosozawa, S, Matsumoto, H, Jordan, P. M, Fagerness, P. E, Pryde, L. M, Scott, A. I

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Biosynthesis of porphyrins and corrins. Direct observation of an enzyme-substrate complex by tritium NMR spectroscopy by Evans, Jeremy N. S., Fagerness, Paul E., Mackenzie, Neil E., Scott, A. Ian

“…Recent studies from this laboratory have demonstrated the power of CMR spectroscopy in defining the structure and stereochemistry of enzyme-inhibitor and…”
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Nuclear Magnetic Resonance Studies of Blood Platelets [and Discussion] by Costa, J. L., Dobson, C. M., Kirk, K. L., Poulsen, F. M., Valeri, C. R., Vecchione, J. J., Cox, S. F. J., Gibson, J. F., Sheppard, R. A., Micklem, K. J., Pasternak, C. A., Scott, A. I., Burton, G., Fagerness, P. E., Sidebottom, P. J., Baxter, R. L.

“…Blood platelets contain membrane-enclosed granules which have inside them high concentrations of 5-hydroxytryptamine (serotonin) along with adenine nucleotides…”
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Biosynthesis of porphyrins and corrins. II: Isolation, purification, and NMR investigations of the phorphobilinogen-deaminase covalent complex by EVANS, J. N. S, BURTON, G, FAGERNESS, P. E, MACKENZIE, N. E, SCOTT, A. I

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Control of porphyrin biosynthesis in Rhodopseudomonas spheroides and Propionibacterium shermanii. A direct 13C nuclear-magnetic-resonance spectroscopy study by Burton, G, Jordan, P M, MacKenzie, N E, Fagerness, P E, Scott, A I

“…The facultative anaerobes Rhodopseudomonas spheroides and Propionibacterium shermanii were grown under anaerobic and aerobic conditions. The effect of light…”
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Spectroscopic studies of delavirdine mesylate (U-90,152T) a bis(heteroaryl)piperazine (BHAP) HIV reverse transcriptase inhibitor by Farley, Kathleen A., Walker, Gregory S., Robins, Russell H., Kupstas-Guido, Jane E., Duholke, Wayne K., Romero, Donna L., Morge, Raymond A., Meulman, Paul A., Chao, Robert S., Havens, Jeffrey L., Gage, James R., Lyster, Mark A., Fagerness, Paul E., Martin, Gary E.

“…Complete spectral assignments, including mass spectral fragmentation pathways, 1H and 13C resonances, and major infrared absorbance bands for the BHAP…”
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Pyridopyrimidines. 9. An unusual rearrangement in the 8-substituted pyrido[2,3-d]pyrimidine series. Application of the selective nuclear Overhauser effect to unambiguous proton chemical shift assignment by Srinivasan, Ananthachari, Fagerness, Paul E, Broom, Arthur D

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