Search Results - "FADEEL, B."

Nanomedicine: towards innovative solutions in the clinic by Fadeel, B.

“…Click here to view the Review by Sindhwani S and Chan WCW…”
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Nanosafety: towards safer design of nanomedicines by Fadeel, B.

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Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals by Maeda, A, Fadeel, B

“…Necrosis leads to the release of so-called damage-associated molecular patterns (DAMPs), which may provoke inflammatory responses. However, the release of…”
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Systems biology approaches in nanosafety research with special reference to carbon-based nanomaterials by Fadeel, B.

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Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease by FADEEL, B., ORRENIUS, S.

“… Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the maintenance of tissue homeostasis in the adult organism…”
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Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus? by Shvedova, A A, Kisin, E R, Porter, D, Schulte, P, Kagan, V E, Fadeel, B, Castranova, V

“…Nanotechnology is an emerging science involving manipulation of materials at the nanometer scale. There are several exciting prospects for the application of…”
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Programmed cell clearance by Fadeel, B

“…Apoptosis, a physiological process of self-annihilation, is essential during development and for the maintenance of tissue homeostasis. Considerable efforts…”
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Cobalt nanoparticles trigger ferroptosis‐like cell death (oxytosis) in neuronal cells: Potential implications for neurodegenerative disease by Gupta, Govind, Gliga, Anda, Hedberg, Jonas, Serra, Angela, Greco, Dario, Odnevall Wallinder, Inger, Fadeel, Bengt

“…The neurotoxicity of hard metal‐based nanoparticles (NPs) remains poorly understood. Here, we deployed the human neuroblastoma cell line SH‐SY5Y differentiated…”
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Graphene oxide is degraded by neutrophils and the degradation products are non-genotoxic by Mukherjee, Sourav P, Gliga, Anda R, Lazzaretto, Beatrice, Brandner, Birgit, Fielden, Matthew, Vogt, Carmen, Newman, Leon, Rodrigues, Artur F, Shao, Wenting, Fournier, Philip M, Toprak, Muhammet S, Star, Alexander, Kostarelos, Kostas, Bhattacharya, Kunal, Fadeel, Bengt

“…Neutrophils were previously shown to digest oxidized carbon nanotubes through a myeloperoxidase (MPO)-dependent mechanism, and graphene oxide (GO) was found to…”
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Keeping it real: The importance of material characterization in nanotoxicology by Fadeel, Bengt, Fornara, Andrea, Toprak, Muhammet S., Bhattacharya, Kunal

“…Nanomaterials are small and the small size and corresponding large surface area of nanomaterials confers specific properties, making these materials desirable…”
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Immunosafety assessment of engineered nanomaterials by Fadeel, B.

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Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid‐induced bone growth impairment by Zaman, Farasat, Zhao, Yunhan, Celvin, Bettina, Mehta, Hemal H., Wan, Junxiang, Chrysis, Dionisios, Ohlsson, Claes, Fadeel, Bengt, Cohen, Pinchas, Sävendahl, Lars

“…ABSTRACTGlucocorticoids (GCs) are frequently used to treat chronic disorders in children, including inflammation and cancer. Prolonged treatment with GCs is…”
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Tackling chondrocyte hypertrophy with multifunctional nanoparticles by Bottini, M, Magrini, A, Fadeel, B, Rosato, N

“…Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1,2 OA is a…”
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Biodegradation of Single-Walled Carbon Nanotubes by Eosinophil Peroxidase by Andón, Fernando T., Kapralov, Alexandr A., Yanamala, Naveena, Feng, Weihong, Baygan, Arjang, Chambers, Benedict J., Hultenby, Kjell, Ye, Fei, Toprak, Muhammet S., Brandner, Birgit D., Fornara, Andrea, Klein-Seetharaman, Judith, Kotchey, Gregg P., Star, Alexander, Shvedova, Anna A., Fadeel, Bengt, Kagan, Valerian E.

“…Eosinophil peroxidase (EPO) is one of the major oxidant‐producing enzymes during inflammatory states in the human lung. The degradation of single‐walled carbon…”
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A journey of hope: lessons learned from studies on rare diseases and orphan drugs by WÄSTFELT, M., FADEEL, B., HENTER, J.‐I.

“… Rare diseases are frequently life‐threatening or chronically debilitating and the impact on the quality of life of affected patients and their family members…”
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Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance by Fadeel, B, Ottosson, A, Pervaiz, S

“…Apoptosis, a form of programmed cell death, enables organisms to maintain tissue homeostasis through deletion of extraneous cells and also serves as a means to…”
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Genotoxicity of carbon nanofibers: Are they potentially more or less dangerous than carbon nanotubes or asbestos? by Kisin, E.R., Murray, A.R., Sargent, L., Lowry, D., Chirila, M., Siegrist, K.J., Schwegler-Berry, D., Leonard, S., Castranova, V., Fadeel, B., Kagan, V.E., Shvedova, A.A.

“…The production of carbon nanofibers and nanotubes (CNF/CNT) and their composite products is increasing globally. CNF are generating great interest in…”
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Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation by Gupta, Govind, Kaur, Jasreen, Bhattacharya, Kunal, Chambers, Benedict J., Gazzi, Arianna, Furesi, Giulia, Rauner, Martina, Fuoco, Claudia, Orecchioni, Marco, Delogu, Lucia Gemma, Haag, Lars, Stehr, Jan Eric, Thomen, Aurélien, Bordes, Romain, Malmberg, Per, Seisenbaeva, Gulaim A., Kessler, Vadim G., Persson, Michael, Fadeel, Bengt

“…Nanoparticles (NPs) elicit sterile inflammation, but the underlying signaling pathways are poorly understood. Here, we report that human monocytes are…”
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Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant by Bhattacharya, Kunal, El-Sayed, Ramy, Andón, Fernando T., Mukherjee, Sourav P., Gregory, Joshua, Li, Hu, Zhao, Yinchen, Seo, Wanji, Fornara, Andrea, Brandner, Birgit, Toprak, Muhammet S., Leifer, Klaus, Star, Alexander, Fadeel, Bengt

“…Carbon nanotubes (CNTs) may elicit inflammatory responses following pulmonary exposure. Conversely, enzymatic biodegradation of CNTs by inflammatory cells has…”
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Bridge over troubled waters: understanding the synthetic and biological identities of engineered nanomaterials by Fadeel, Bengt, Feliu, Neus, Vogt, Carmen, Abdelmonem, Abuelmagd M., Parak, Wolfgang J.

“…Engineered nanomaterials offer exciting opportunities for ‘smart’ drug delivery and in vivo imaging of disease processes, as well as in regenerative medicine…”
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