Search Results - "FACCHIANO, A"

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist by Ubertini, V, Norelli, G, D'Arcangelo, D, Gurtner, A, Cesareo, E, Baldari, S, Gentileschi, M P, Piaggio, G, Nisticò, P, Soddu, S, Facchiano, A, Bossi, G

“…The TP53 tumor-suppressor gene is frequently mutated in human cancer. Missense mutations can add novel functions (gain-of-function, GOF) that promote tumor…”
Get full text

Canakinumab in adults with steroid-refractory pyoderma gangrenosum by Kolios, A.G.A., Maul, J.-T., Meier, B., Kerl, K., Traidl-Hoffmann, C., Hertl, M., Zillikens, D., Röcken, M., Ring, J., Facchiano, A., Mondino, C., Yawalkar, N., Contassot, E., Navarini, A.A., French, L.E.

“…Summary Background Pyoderma gangrenosum (PG) is a rare, neutrophilic, ulcerative skin disease that is difficult to treat, especially when unresponsive to…”
Get full text

Analysis of galactosemia-linked mutations of GALT enzyme using a computational biology approach by Facchiano, A., Marabotti, A.

“…We describe the prediction of the structural and functional effects of mutations on the enzyme galactose-1-phosphate uridyltransferase related to the genetic…”
Get full text

Pre-Processing MALDI/TOF Mass Spectra by Using Geena 2 by Romano, P, Profumo, A, Facchiano, A

“…Geena 2 is a tool for filtering, averaging, and aligning MALDI/TOF mass spectra, designed to assist scientists in the analysis of high volumes of data and…”
Get more information

MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sézary syndrome by Narducci, M G, Arcelli, D, Picchio, M C, Lazzeri, C, Pagani, E, Sampogna, F, Scala, E, Fadda, P, Cristofoletti, C, Facchiano, A, Frontani, M, Monopoli, A, Ferracin, M, Negrini, M, Lombardo, G A, Caprini, E, Russo, G

“…Sézary syndrome (SS) is an incurable leukemic variant of cutaneous T-cell lymphoma and its pathogenesis is still unknown. Diagnosis/prognosis may strongly…”
Get full text

Clinical and molecular spectra in galactosemic patients from neonatal screening in northeastern Italy: Structural and functional characterization of new variations in the galactose-1-phosphate uridyltransferase (GALT) gene by Viggiano, E., Marabotti, A., Burlina, A.P., Cazzorla, C., D'Apice, M.R., Giordano, L., Fasan, I., Novelli, G., Facchiano, A., Burlina, A.B.

“…Classical galactosemia is an autosomal recessive inborn error of metabolism due to mutations of the GALT gene leading to toxic accumulation of galactose and…”
Get full text

Therapeutic implications of autophagy modulation in prostate cancer by Giampietri, C., Petrungaro, S., Facchiano, A., Filippini, A., Ziparo, E.

Get full text

Proteomic profile in familial breast cancer patients by Garrisi, V.M., Tommasi, S., Facchiano, A., Bongarzone, I., De Bortoli, M., Cremona, M., Cafagna, V., Abbate, I., Tufaro, A., Quaranta, M., Paradiso, A.

“…Breast cancer is the most common form of cancer affecting women, and the strongest risk factor remains family history. Although screening in asymptomatic women…”
Get full text

Active Sequences Collection (ASC) database: a new tool to assign functions to protein sequences by Facchiano, Angelo M., Facchiano, Antonio, Facchiano, Francesco

“…Active Sequences Collection (ASC) is a collection of amino acid sequences, with an unique feature: only short sequences are collected, with a demonstrated…”
Get full text

Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo by Faraone, Debora, Aguzzi, Maria Simona, Toietta, Gabriele, Facchiano, Angelo M., Facchiano, Francesco, Magenta, Alessandra, Martelli, Fabio, Truffa, Silvia, Cesareo, Eleonora, Ribatti, Domenico, Capogrossi, Maurizio C., Facchiano, Antonio

“…Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived…”
Get full text

The fluorescent monomeric protein Kusabira Orange. Pressure effect on its structure and stability by Picart-Palmade, L, Chevalier-Lucia, D, Lange, R, Facchiano, A, Pennacchio, A, Staiano, M, D'Auria, S

“…The structure and stability of the fluorescent protein monomeric Kusabira Orange (mKO), a GFP-like protein, was studied under different pressure levels and in…”
Get full text

The role of transglutaminase-2 and its substrates in human diseases by Facchiano, Francesco, Facchiano, Antonio, Facchiano, Angelo M

“…The most characteristic enzymatic function of the class of enzymes known as transglutaminases (TG, EC 2.3.2.13) is the formation of covalent bonds between…”
Get full text

Helix stabilizing factors and stabilization of thermophilic proteins: an X-ray based study by Facchiano, A M, Colonna, G, Ragone, R

“…We have compared the X-ray structures of 13 thermophilic proteins with their mesophilic homologues, in order to bring out differences in the stability of…”
Get full text

A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome by Cicatiello, L, Scafoglio, C, Altucci, L, Cancemi, M, Natoli, G, Facchiano, A, Iazzetti, G, Calogero, R, Biglia, N, De Bortoli, M, Sfiligoi, C, Sismondi, P, Bresciani, F, Weisz, A

“…Estrogen controls key cellular functions of responsive cells including the ability to survive, replicate, communicate and adapt to the extracellular milieu…”
Get full text

Simulation of conformational changes occurring when a protein interacts with its receptor by Costantini, S., Colonna, G., Facchiano, A.M.

“…In order to simulate the conformational changes occurring when a protein interacts with its receptor, we firstly evaluated the structural differences between…”
Get full text

Homology modelling of the human eukaryotic initiation factor 5A (eIF-5A) by Facchiano, Angelo M., Stiuso, Paola, Chiusano, Maria Luisa, Caraglia, Michele, Giuberti, Gaia, Marra, Monica, Abbruzzese, Alberto, Colonna, Giovanni

“…Homology modelling of the human eIF-5A protein has been performed by using a multiple predictions strategy. As the sequence identity between the target and the…”
Get full text

Comparative Study of Cytokine Content in the Plasma and Wound Exudate from Children with Severe Burns by Mikhal'chik, E. V, Piterskaya, J. A, Budkevich, L. Y, Pen'kov, L. Yu, Facchiano, A, De Luca, C, Ibragimova, G. A, Korkina, L. G

“…The content of 27 cytokines was measured in blood plasma from 19 children with severe uncomplicated burns (group 1) and complicated burns (septic toxemia,…”
Get full text

PO-31 Thrombin cleaves in vitro FGF-2 and modulates its biological activity by Totta, P, De Cristofaro, R, Capogrossi, M.C, Facchiano, A

Get full text

A novel RGDS-analog inhibits angiogenesis in vitro and in vivo by Aguzzi, M.S., Facchiano, F., Ribatti, D., Gaeta, R., Casadio, R., Rossi, I., Capogrossi, M.C., Facchiano, A.

“…In this study the anti-angiogenic action of a novel non-peptide RGDS-analog named RAM was tested in vitro and in vivo. RAM inhibited FGF-2-induced chemotaxis…”
Get full text

Alteration in the ubiquitin structure and function in the human lens: a possible mechanism of senile cataractogenesis by Stiuso, P, Libondi, T, Facchiano, A.M, Colicchio, P, Ferranti, P, Lilla, S, Colonna, G

“…High-performance liquid chromatography purification followed by mass spectrometry analyses highlighted that human senile cataractous lens includes a 8182 Da…”
Get full text