Search Results - "FABRE, J. W."

Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava by Fabre, J W, Grehan, A, Whitehorne, M, Sawyer, G J, Dong, X, Salehi, S, Eckley, L, Zhang, X, Seddon, M, Shah, A M, Davenport, M, Rela, M

“…Hydrodynamic gene delivery is an attractive option for non-viral liver gene therapy, but requires evaluation of efficacy, safety and clinically applicable…”
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Technical requirements for effective regional hydrodynamic gene delivery to the left lateral lobe of the rat liver by Sawyer, G J, Zhang, X, Fabre, J W

“…Hydrodynamic gene delivery to the liver is an attractive approach for clinical liver gene therapy, but critical aspects of technique remain uncertain. There…”
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The allogeneic response and tumor immunity by Fabre, John W

“…The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but…”
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Cardiovascular function following acute volume overload for hydrodynamic gene delivery to the liver by SAWYER, G. J, DONG, X, WHITEHORNE, M, GREHAN, A, SEDDON, M, SHAH, A. M, ZHANE, X, FABRE, J. W

“…Hydrodynamic gene delivery to the liver is a valuable experimental tool and an attractive option for nonviral gene therapy of liver disease. However, little…”
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Integrin-mediated transfection with peptides containing arginine-glycine-aspartic acid domains by HART, S. L, COLLINS, L, GUSTAFSSON, K, FABRE, J. W

“…Two synthetic peptides comprising an RGD moiety for integrin binding and a polylysine moiety for DNA binding were tested for transfection efficiency under a…”
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A remarkable permeability of canalicular tight junctions might facilitate retrograde, non-viral gene delivery to the liver via the bile duct by Hu, J, Zhang, X, Dong, X, Collins, L, Sawyer, G J, Fabre, J W

“…Aims: To establish the extent of retrograde bile duct infusion at an ultrastructural level, as a preliminary step before evaluating the efficacy of gene…”
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Rejection of skin allografts by indirect allorecognition of Donor class I major histocompatibility complex peptides by FANGMANN, J, DALCHAU, R, FABRE, J. W

“…LEW (RT1l) rats were immunized with peptides corresponding to the alpha helical region of the alpha 1 domain (peptide 1), the beta sheet of the alpha 2 domain…”
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Efficient gene delivery to vascular smooth muscle cells using a nontoxic, synthetic peptide vector system targeted to membrane integrins: a first step toward the gene therapy of chronic rejection by Li, J.-M, Collins, L, Zhang, X, Gustafsson, K, Fabre, J.W

“…Chronic rejection is now the major cause of allograft failure. A prominent characteristic of the histopathology is extensive intimal proliferation of vascular…”
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The detailed distribution of MHC Class II antigens in normal human organs by Daar, A S, Fuggle, S V, Fabre, J W, Ting, A, Morris, P J

“…In a previous article we described the detailed tissue distribution of MHC class I antigens. In this study, we have used a monoclonal antibody, NFK1, to study…”
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Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat by MILTON, A. D, FABRE, J. W

“…DA (RT1a) hearts were transplanted into PVG (RT1c) or DA recipients, excised on days 1, 3, 5, or 7 after grafting, and examined by immunohistological…”
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The detailed distribution of HLA-A, B, C antigens in normal human organs by Daar, A S, Fuggle, S V, Fabre, J W, Ting, A, Morris, P J

“…We have used a monoclonal antibody, PA2.6, directed against the heavy chain of HLA-ABC antigens to study the detailed tissue distribution of MHC class I…”
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Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal domain by SHENG YUN, GUSTAFSSON, K, FABRE, J. W

“…The class II transactivator (CIITA) is a bi- or multifunctional domain protein that acts as a transcriptional activator and plays a critical role in the…”
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Characterization of the tissue macrophage and the interstitial dendritic cell as distinct leukocytes normally resident in the connective tissue of rat heart by SPENCER, S. C, FABRE, J. W

“…Immunohistological studies with a mouse anti-rat macrophage mAb (BMAC-5) demonstrated the presence of numerous positive cells in the interstitial connective…”
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Indirect T cell allorecognition of donor antigens contributes to the rejection of vascularized kidney allografts by Benham, A M, Sawyer, G J, Fabre, J W

“…This report demonstrates for the first time that indirect T cell allorecognition of donor antigens can contribute to the effector mechanism of rejection of…”
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Specific suppression of interleukin-2 biosynthesis by synthetic antisense oligodeoxynucleotides does not influence allograft rejection by Yun, S, Sawyer, G, Zhang, X, Gustafsson, K, Fabre, J.W

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Comparison of adenovirus gene transfer to vascular endothelial cells in cell culture, organ culture, and in vivo by MERRICK, A. F, SHEWRING, L. D, SAWYER, G. J, GUSTAFSSON, K. T, FABRE, J. W

“…A replication-defective adenovirus 5 vector carrying the beta-galactosidase reporter gene was tested for its efficiency for gene delivery to vascular…”
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Chemical composition and tissue distribution of the human CDw44 glycoprotein by FLANAGAN, B. F, DALCHAU, R, ALLEN, A. K, DAAR, A. S, FABRE, J. W

“…The CDw44 glycoprotein was purified from 2.3 x 10(11) CD3+ CD4+ CD8- T-chronic lymphocytic leukaemia (CLL) cells using F10-44-2 monoclonal antibody affinity…”
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A three-cell cluster hypothesis for noncognate T-B collaboration via direct T cell recognition of allogeneic dendritic cells by KELLY, C. M, BENHAM, A. M, SAWYER, G. J, DALCHAU, R, FABRE, J. W

“…In this article, we propose that T cell help for B cells can occur via an unusual three-cell cluster, with recipient CD4+ T helper cells interacting via direct…”
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Specific suppression of interleukin 2 biosynthesis by synthetic antisense oligodeoxynucleotides does not influence allograft rejection by SHENG YUN, SAWYER, G. J, XIAOHONG ZHANG, GUSTAFSSON, K, FABRE, J. W

“…Interleukin (IL)-2 supplementation can reverse both blood transfusion-induced tolerance to kidney allografts and spontaneous tolerance to liver allografts in…”
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T cell recognition of donor major histocompatibility complex class I peptides during allograft rejection by Fangmann, J, Dalchau, R, Sawyer, G J, Priestley, C A, Fabre, J W

“…LEW (RTI1) recipients of DA (RTIav1) skin and kidney allografts were tested for the capacity of their T lymphocytes to proliferate to three 22-24-amino acid…”
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