Search Results - "FABIAN, Miles A."

The origin of the anomeric effect: conformational analysis of 2-methoxy-1,3-dimethylhexahydropyrimidine by Perrin, Charles L, Armstrong, Kathleen B, Fabian, Miles A

“…The anomeric effect is thought to be the result of either molecular orbital interactions, which stabilize the axial conformer, or electrostatic interactions,…”
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Tuning a Three-Component Reaction For Trapping Kinase Substrate Complexes by Statsuk, Alexander V, Maly, Dustin J, Seeliger, Markus A, Fabian, Miles A, Biggs, William H, Lockhart, David J, Zarrinkar, Patrick P, Kuriyan, John, Shokat, Kevan M

“…The upstream protein kinases responsible for thousands of phosphorylation events in the phosphoproteome remain to be discovered. We developed a three-component…”
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Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors by Patel, Hitesh K., Grotzfeld, Robert M., Lai, Andiliy G., Mehta, Shamal A., Milanov, Zdravko V., Chao, Qi, Sprankle, Kelly G., Carter, Todd A., Velasco, Anne Marie, Fabian, Miles A., James, Joyce, Treiber, Daniel K., Lockhart, David J., Zarrinkar, Patrick P., Bhagwat, Shripad S.

“…A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral…”
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Solvation Effect on Steric Bulk of Ionic Substituents: Imidazolium vs Imidazole by Perrin, Charles L, Fabian, Miles A, Armstrong, Kathleen B

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Absence of Reverse Anomeric Effect in Glycosylimidazoles by Perrin, Charles L, Fabian, Miles A, Brunckova, Jarmila, Ohta, Brian K

“…The so-called reverse anomeric effect is the preference of cationic substituents for the equatorial position on a pyranose ring, but it is not consistent with…”
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Response to Molecule-kinase interaction map by Fabian, Miles A, Biggs, William H, Treiber, Daniel K, Zarrinkar, Patrick P, Lockhart, David J

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Reply to BIRB-796 is not an effective ABL(T315I) inhibitor by Fabian, Miles A, Biggs, William H, Treiber, Daniel K, Zarrinkar, Patrick P, Lockhart, David J

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Multicomponent NMR Titration for Simultaneous Measurement of Relative pKas by PERRIN, Charles L., FABIAN, Miles A.

“…An NMR titration method has been developed to simultaneously measure the difference in acid dissociation constants (delta pKa) of two or more compounds with…”
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Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display by Chin, Jason W, Grotzfeld, Robert M, Fabian, Miles A, Schepartz, Alanna

“…Synthetic genes for avian pancreatic polypeptide (aPP) and for the miniature DNA binding protein PPBR4 were cloned and expressed on the surface of M13…”
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Electrostatic Mechanism for DNA Bending by bZIP Proteins by Paolella, David N, Liu, Yichin, Fabian, Miles A, Schepartz, Alanna

“…Biology is replete with examples of protein-induced DNA bending, yet the forces responsible for bending have been neither established nor quantified…”
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A small molecule-kinase interaction map for clinical kinase inhibitors by Zarrinkar, Patrick P, Floyd, Mark, Lai, Andiliy G, Atteridge, Corey E, Carter, Todd A, Galvin, Margaret, Mehta, Shamal A, Lélias, Jean-Michel, Wodicka, Lisa M, Benedetti, Michael G, Azimioara, Mihai D, Treiber, Daniel K, Insko, Darren E, Insko, Michael A, Edeen, Philip T, Gerlach, Jay L, Fabian, Miles A, Grotzfeld, Robert M, Lockhart, David J, Patel, Hitesh K, Milanov, Zdravko V, Ciceri, Pietro, Biggs, William H, Herrgard, Sanna, Velasco, Anne Marie, Ford, Julia M

“…Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring…”
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Unusually Strong Dependence of Conformation on Solvent by Perrin, Charles L, Fabian, Miles A, Rivero, Ignacio A

“…Relative partition coefficients between aqueous methanol and pentane of the two stereoisomers of a series of 4-tert-butylcyclohexylamines were measured by NMR…”
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Absence of Reverse Anomeric Effect: Conformational Analysis of Glucosylimidazolium and Glucosylimidazole by Fabian, Miles A, Perrin, Charles L, Sinnott, Michael L

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Inhibition of Drug-Resistant Mutants of ABL, KIT, and EGF Receptor Kinases by Carter, Todd A., Wodicka, Lisa M., Shah, Neil P., Velasco, Anne Marie, Fabian, Miles A., Treiber, Daniel K., Milanov, Zdravko V., Atteridge, Corey E., Biggs, William H., Edeen, Philip T., Floyd, Mark, Ford, Julia M., Grotzfeld, Robert M., Herrgard, Sanna, Insko, Darren E., Mehta, Shamal A., Patel, Hitesh K., Pao, William, Sawyers, Charles L., Varmus, Harold, Zarrinkar, Patrick P., Lockhart, David J.

“…To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the emergence of drug resistance in…”
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BIRB-796 is not an effective ABL(T315I) inhibitor by Druker, Brian J, O'Hare, Thomas

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Molecule-kinase interaction map by Buolamwini, John K, Kamath, Shantaram

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Basicities of cycloalkylamines: Baeyer strain theory revisited by Perrin, Charles L., Fabian, Miles A., Rivero, Ignacio A.

“…A new, accurate NMR titration method was utilized to determine relative basicities in four solvents of the two norbornylamines 2 and a series of…”
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Multicomponent NMR Titration for Simultaneous Measurement of Relative p K a s by Perrin, Charles L., Fabian, Miles A.

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Multicomponent NMR Titration for Simultaneous Measurement of Relative pKas by PERRIN, Charles L., FABIAN, Miles A.

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Multicomponent NMR Titration for Simultaneous Measurement of Relative pK as by Perrin, Charles L., Fabian, Miles A.

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