Search Results - "FA, MAURO"

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach by Teich, Andrew F., Nicholls, Russell E., Puzzo, Daniela, Fiorito, Jole, Purgatorio, Rosa, Fa’, Mauro, Arancio, Ottavio

“…Therapeutic attempts to cure Alzheimer’s disease (AD) have failed, and new strategies are desperately needed. Motivated by this reality, many laboratories…”
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Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease by Trinchese, Fabrizio, Fa', Mauro, Liu, Shumin, Zhang, Hong, Hidalgo, Ariel, Schmidt, Stephen D, Yamaguchi, Hisako, Yoshii, Narihiko, Mathews, Paul M, Nixon, Ralph A, Arancio, Ottavio

“…Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation…”
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Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory by Puzzo, Daniela, Privitera, Lucia, Fa', Mauro, Staniszewski, Agnieszka, Hashimoto, Gakuji, Aziz, Fahad, Sakurai, Mikako, Ribe, Elena M., Troy, Carol M., Mercken, Marc, Jung, Sonia S., Palmeri, Agostino, Arancio, Ottavio

“…Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a…”
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Furoxans (1,2,5-Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents by Schiefer, Isaac T, VandeVrede, Lawren, Fa’, Mauro, Arancio, Ottavio, Thatcher, Gregory R. J

“…Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents…”
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Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease by Lee, Linda, Dale, Elena, Staniszewski, Agnes, Zhang, Hong, Saeed, Faisal, Sakurai, Mikako, Fa', Mauro, Orozco, Ian, Michelassi, Francesco, Akpan, Nsikan, Lehrer, Helaina, Arancio, Ottavio

“…Learning and memory and the underlying cellular correlate, long-term synaptic plasticity, involve regulation by posttranslational modifications (PTMs). Here we…”
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Tau is not necessary for amyloid-β-induced synaptic and memory impairments by Puzzo, Daniela, Argyrousi, Elentina K, Staniszewski, Agnieszka, Zhang, Hong, Calcagno, Elisa, Zuccarello, Elisa, Acquarone, Erica, Fa', Mauro, Li Puma, Domenica D, Grassi, Claudio, D'Adamio, Luciano, Kanaan, Nicholas M, Fraser, Paul E, Arancio, Ottavio

“…The amyloid hypothesis posits that the amyloid-beta (Aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism…”
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Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits by Izzo, Nicholas J, Staniszewski, Agnes, To, Lillian, Fa, Mauro, Teich, Andrew F, Saeed, Faisal, Wostein, Harrison, Walko, 3rd, Thomas, Vaswani, Anisha, Wardius, Meghan, Syed, Zanobia, Ravenscroft, Jessica, Mozzoni, Kelsie, Silky, Colleen, Rehak, Courtney, Yurko, Raymond, Finn, Patricia, Look, Gary, Rishton, Gilbert, Safferstein, Hank, Miller, Miles, Johanson, Conrad, Stopa, Edward, Windisch, Manfred, Hutter-Paier, Birgit, Shamloo, Mehrdad, Arancio, Ottavio, LeVine, 3rd, Harry, Catalano, Susan M

“…Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive…”
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Design and Synthesis of Neuroprotective Methylthiazoles and Modification as NO-Chimeras for Neurodegenerative Therapy by Qin, Zhihui, Luo, Jia, VandeVrede, Lawren, Tavassoli, Ehsan, Fa’, Mauro, Teich, Andrew F, Arancio, Ottavio, Thatcher, Gregory R. J

“…Learning and memory deficits in Alzheimer’s disease (AD) result from synaptic failure and neuronal loss, the latter caused in part by excitotoxicity and…”
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Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors by Schiefer, Isaac T, Tapadar, Subhasish, Litosh, Vladislav, Siklos, Marton, Scism, Rob, Wijewickrama, Gihani T, Chandrasena, Esala P, Sinha, Vaishali, Tavassoli, Ehsan, Brunsteiner, Michael, Fa’, Mauro, Arancio, Ottavio, Petukhov, Pavel, Thatcher, Gregory R. J

“…Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological event in a wide range of…”
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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus by Puzzo, Daniela, Privitera, Lucia, Leznik, Elena, Fà, Mauro, Staniszewski, Agnieszka, Palmeri, Agostino, Arancio, Ottavio

“…Amyloid-beta (Abeta) peptides are produced in high amounts during Alzheimer's disease, causing synaptic and memory dysfunction. However, they are also released…”
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LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent by Puzzo, Daniela, Piacentini, Roberto, Fá, Mauro, Gulisano, Walter, Li Puma, Domenica D, Staniszewski, Agnes, Zhang, Hong, Tropea, Maria Rosaria, Cocco, Sara, Palmeri, Agostino, Fraser, Paul, D'Adamio, Luciano, Grassi, Claudio, Arancio, Ottavio

“…The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its…”
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Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease by Francis, Yitshak I, Fà, Mauro, Ashraf, Haider, Zhang, Hong, Staniszewski, Agnieszka, Latchman, David S, Arancio, Ottavio

“…Epigenetic mechanisms such as post-translational histone modifications are increasingly recognized for their contribution to gene activation and silencing in…”
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Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade by Gulisano, Walter, Maugeri, Daniele, Baltrons, Marian A, Fà, Mauro, Amato, Arianna, Palmeri, Agostino, D'Adamio, Luciano, Grassi, Claudio, Devanand, D P, Honig, Lawrence S, Puzzo, Daniela, Arancio, Ottavio

“…The "Amyloid Cascade Hypothesis" has dominated the Alzheimer's disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the…”
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Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade by Acquarone, Erica, Argyrousi, Elentina K, van den Berg, Manon, Gulisano, Walter, Fà, Mauro, Staniszewski, Agnieszka, Calcagno, Elisa, Zuccarello, Elisa, D'Adamio, Luciano, Deng, Shi-Xian, Puzzo, Daniela, Arancio, Ottavio, Fiorito, Jole

“…Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer's disease…”
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Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease by Lee, Linda, Dale, Elena, Staniszewski, Agnes, Zhang, Hong, Saeed, Faisal, Sakurai, Mikako, Fa', Mauro, Orozco, Ian, Michelassi, Francesco, Akpan, Nsikan, Lehrer, Helaina, Arancio, Ottavio

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Kappa Opioid Receptor Activation Disrupts Prepulse Inhibition of the Acoustic Startle in Rats by Bortolato, Marco, Aru, Gian Nicola, Frau, Roberto, Orrù, Marco, Fà, Mauro, Manunta, Mario, Puddu, Mara, Mereu, Giampaolo, Gessa, Gian Luigi

“…Compelling evidence indicates that kappa opioid receptor (KOR) agonists produce perceptual distortions in animals and humans, yet the mechanism of action and…”
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Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits by Tamayev, Robert, Matsuda, Shuji, Fà, Mauro, Arancio, Ottavio, D'Adamio, Luciano, Südhof, Thomas C.

“…According to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by…”
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Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease by Zhang, Hong, Gong, Bing, Liu, Shumin, Fa', Mauro, Ninan, Ipe, Staniszewski, Agnieszka, Arancio, Ottavio

“…To search for potential mechanism that might alter synaptic transmission following Abeta increase we have examined the presynaptic component of transmitter…”
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Dynamin 1 is required for memory formation by Fà, Mauro, Staniszewski, Agnieszka, Saeed, Faisal, Francis, Yitshak I, Arancio, Ottavio

“…Dynamin 1-3 isoforms are known to be involved in endocytotic processes occurring during synaptic transmission. No data has directly linked dynamins yet with…”
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Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease by Koppensteiner, Peter, Trinchese, Fabrizio, Fà, Mauro, Puzzo, Daniela, Gulisano, Walter, Yan, Shijun, Poussin, Arthur, Liu, Shumin, Orozco, Ian, Dale, Elena, Teich, Andrew F., Palmeri, Agostino, Ninan, Ipe, Boehm, Stefan, Arancio, Ottavio

“…The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here,…”
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